Healing of subacute tympanic membrane perforations in chinchillas treated with epidermal growth factor and pentoxifylline

Otology and Neurotology

Volumn 27, Issue 5, 2006, Pages 720-727

  Ramalho, Jeanne R O ^a,b   Bento, Ricardo F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Chinchilla; Epidermal growth factor; Middle ear; Pentoxifylline; Tympanoplasty; Wound healing

Indexed keywords

EPIDERMAL GROWTH FACTOR; PENTOXIFYLLINE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHINCHILLA; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; EARDRUM PERFORATION; FEMALE; HEALING; HISTOLOGY; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-BACTERIAL AGENTS; CHINCHILLA; DRUG THERAPY, COMBINATION; EPIDERMAL GROWTH FACTOR; FEMALE; MALE; PENTOXIFYLLINE; TREATMENT OUTCOME; TYMPANIC MEMBRANE; TYMPANIC MEMBRANE PERFORATION; VASODILATOR AGENTS; WOUND HEALING;

EID: 33746852125     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/01.mao.0000226316.04940.f9     Document Type: Article

References (28)

1. Bento RF, Miniti A, Marone SAM. Tratado de otologia. São Paulo: EDUSP, 1998.
2. Laidlaw DW, Costantino PD, Govindaraj S, et al. Tympanic membrane repair with a dermal allograft. Laryngoscope 2001;111:702-7.
3. Oliveira JAA, Hyppolito MA, Netto JC, et al. Myringoplasty using a new biomaterial allograft. Rev Bras Otorinolaringol 2003;69:649-55.
4. Carpenter G, Cohen S. Human epidermal growth factor and the proliferation of human fibroblasts. J Cell Physiol 1976;88:227-37.
5. Aharonov A, Pruss RM, Herschman HR. Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells. J Biol Chem 1978;253:3970-7.
6. Bennett NT, Schultz GS. Growth factors and wound healing: Part II. Role in normal and chronic wound healing. Am J Surg 1993;166:74-81.
7. O'Daniel TG, Petitjean M, Jones SC, et al. Epidermal growth factor binding and action on tympanic membranes. Ann Otol Rhinol Laryngol 1990;99:80-4.
8. Mondain M, Ryan A. Epidermal growth factor and basic fibroblast growth factor are induced in guinea-pig tympanic membrane following traumatic perforation. Acta Otolaryngol 1995;115:50-4.
9. Somers T, Goovaerts G, Schelfhout L, et al. Growth factors in tympanic membrane perforations. Am J Otol 1998;19:428-34.
10. Amoils CP, Jackler RK, Lustig LR. Repair of chronic tympanic membrane perforations using epidermal growth factor. Otolaryngol Head Neck Surg 1992;107:669-83.
11. Lee AJ, Jackler RK, Kato BM, et al. Repair of chronic tympanic membrane perforations using epidermal growth factor: progress toward clinical application. Am J Otol 1994;15:10-8.
12. Dvorak DW, Abbas G, Ali T, et al. Repair of chronic tympanic membrane perforations with long-term epidermal growth factor. Laryngoscope 1995;105:1300-4.
13. Ramsay HA, Heikkonen EJ, Laurila PK. Effect of epidermal growth factor on tympanic membranes with chronic perforations: A clinical trial. Otolaryngol Head Neck Surg 1995;113:375-9.
14. Ward A, Clissold SP. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987;34:50-97.
15. Nemiroff PM. Synergistic effects of pentoxifylline and hyperbaric oxygen on skin flaps. Arch Otolaryngol Head Neck Surg 1988;114:977-81.
16. Armstrong M Jr, Kunar DR, Cummings CW. Effect of pentoxifylline [corrected] on myocutaneous flap viability in pigs. Otolaryngol Head Neck Surg 1993;109:668-75.
17. Jull AB, Waters J, Arroll B. Pentoxifylline for treating venous leg ulcers. Cochrane Database Syst Rev 2002:CD001733.
18. Griffin WL Jr. A retrospective study of traumatic tympanic membrane perforations in a clinical practice. Laryngoscope 1979;89:261-82.
19. Bento RF, Lessa MM, Chung D, et al. Condutas práticas em otologia. São Paulo: Fundação Otorrinolaringologia, 2002.
20. Souza NL. Eutanásia. In: Luca RR, Alexandre SR, Marques T, Souza NL, Merusse JLB, Neves SP, eds. Manual para técnicos em bioterismo. São Paulo: FINEP-COBEA, 1996;157-77.
21. Amoils CP, Jackler RK, Milczuk H, et al. An animal model of chronic tympanic membrane perforation. Otolaryngol Head Neck Surg 1992;106:47-55.
22. Lorena D, Uchio K, Costa AM, et al. Normal scarring: importance of myofibroblasts. Wound Repair Regen 2002;10:86-92.
23. Bankey P, Fiegel V, Singh R, et al. Hypoxia and endotoxin induce macrophage-mediated suppression of fibroblast proliferation. J Trauma 1989;29:972-9, discussion 9-80.
24. Berman B, Duncan MR. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen, glycosaminoglycan, and fibronectin production, and increases collagenase activity. J Invest Dermatol 1989;92:605-10.
25. Gilhar A, Grossman N, Kahanovicz S, et al. Antiproliferative effect of pentoxifylline on psoriatic and normal epidermis. In vitro and in vivo studies. Acta Derm Venereol 1996;76:437-41.
26. Stosic-Grujicic S, Maksimovic D, Badovinac V, et al. Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production. J Autoimmun 2001;16:47-58.
27. Raetsch C, Jia JD, Boigk G, et al. Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis. Gut 2002;50:241-7.
28. Lim AA, Washington AP, Greinwald JH, et al. Effect of pentoxifylline on the healing of guinea pig tympanic membrane. Ann Otol Rhinol Laryngol 2000;109:262-6.