Vascular endothelial growth factor is more important than basic fibroblastic growth factor during ischemic wound healing

Archives of Surgery

Volumn 134, Issue 2, 1999, Pages 200-205

  Corral, Claudio J ^a   Siddiqui, Aamir ^a   Wu, Liancun ^a   Farrell, Catherine L ^b   Lyons, David ^b   Mustoe, Thomas A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; ISOENZYME; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOLOGY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; EPITHELIZATION; FEMALE; GRANULATION TISSUE; HISTOPATHOLOGY; HYPOXIC CELL; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RABBIT; SKIN ULCER; TISSUE REPAIR; TOPICAL DRUG ADMINISTRATION; WOUND HEALING;

ANIMALS; ENDOTHELIAL GROWTH FACTORS; FEMALE; FIBROBLAST GROWTH FACTOR 2; ISCHEMIA; LYMPHOKINES; RABBITS; RNA, MESSENGER; SKIN ULCER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; WOUND HEALING;

EID: 0033057591     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.134.2.200     Document Type: Article

References (41)

1. Clark RF, Henson PM. The Molecular and Cellular Biology of Wound Repair. New York, NY: Plenum Publishing Corp: 1988.
2. Pierce GF, Mustoe TA. Pharmacologic enhancement of wound healing. Ann Rev Med. 1995;46:467-481.
3. Thomas KA. Vascular endothelial growth factor: a potent and selective angiogenic agent. J Biol Chem. 1996;271:603-606.
4. Brown LF, Yeo KT, Berse B, Morgentaler A, Dvorak HF, Rosen S. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 1992;176:1375-1379.
5. Frank S, Hübner G, Breier G, Longaker MT, Greenhalh DG, Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem. 1995;270:12607-12613.
6. Detmar M, Yeo KT, Nagy JA, et al. Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells J Invest Dermatol. 1995;105:44-50.
7. Brogi E, Wu T, Namiki A, Isner JM. Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only. Circulation. 1994;90:649-652.
8. Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992;267:10931-10934.
9. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989;246: 1306-1309.
10. Clauss M, Gerlach M, Gerlach H, et al. Vascular permeability factor: a tumor derived polypeptide that induces endothelial cell and monocyte pro-coagulant activity, and promotes monocyte migration. J Exp Med. 1990;172:1535-1545.
11. Pepper MS, Ferrara N, Orci L, Montesino R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun. 1992;189:824-831.
12. Goto F, Goto K, Weindel K, Folkman J. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation of bovine capillary endothelial cells. Lab Invest. 1993;69:508-517.
13. Stavri GT, Zachary IC, Baskerville PA, Martin JF, Erusalimsky JD. Basic fibroblast growth factor up-regulates the expression of vascular endothelial growth factor in vascular smooth muscle cells: synergistic interaction with hypoxia. Circulation. 1995;92:11-14.
14. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995;146:1029-1039.
15. Mustoe TA, Sang TA, Tarpley JE, Ahn ST. Pierce GF. Role of hypoxia in growth factor responses: differential effects of basic fibroblast growth factor and platelet-derived growth factor in an ischemic wound model. Wound Repair Regeneration. 1994;2:277-283.
16. Pierce GF, Tarpley JE, Yanagihara D, Mustoe TA, Fox GM, Thomason A. Platelet derived growth factor (BB homodimer), transforming growth factor beta-1 and basic fibroblast growth factor in dermal wound healing: neovessel and matrix formation and cessation of repair. Am J Pathol. 1992; 140:1375-1388.
17. Wu L, Pierce GF, Ladin DA, Zhao LL, Rogers D, Mustoe TA. Effects of oxygen in wound responses to growth factors: Kaposi's FGF, but not basic FGF stimulates repair in ischemic wounds. Growth Factors. 1995;12:29-35.
18. Ferrara N, Houck K, Jakeman L, Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev. 1992;13:18-32.
19. Cohen T, Gitay-Goren H, Sharon R, et al. VEGF 121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells. J Biol Chem. 1995;270:11322-11326.
20. Unemori EN, Ferrara N, Bauer EA, Amento EP. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol. 1992;153:557-562.
21. Shweiki D, Itin A, Soffer D. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia initiated angiogenesis. Nature. 1992;359: 843-845.
22. Ikeda E, Achen MC, Breier G, Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem. 1995;270: 19761-19766.
23. Levy AP, Levy NS, Goldberg MA. Post transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem. 1996;271:2746-2753.
24. Ahn ST, Mustoe TA. Effects of ischemia on ulcer wound healing: a new model in the rabbit ear. Ann Plast Surg. 1990;24:17-23.
25. Mustoe TA, Pierce GF, Morishima C, Deuel TF. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J Clin Invest. 1991;87:694-703.
26. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques. 1993; 15:532-537.
27. Siebert PD, Larrick JW. Competitive PCR. Nature. 1992;359:557-558.
28. Siebert PD, Larrick JW. PCR MIMICS: competitive DNA fragments for use as internal standards in quantitative PCR. Biotechniques. 1993;14:244-249.
29. Brucker MJ, Gruskin E, Farrell CL, Siddiqui A, Mustoe TA. Differential expression of PDGF receptor-β in an aging model of wound repair. Wound Repair Regeneration. 1995;13:84.
30. Okumura M, Oruda T, Nakamura T, Yajima M. Effect of basic fibroblast growth factor on wound healing-impaired animal models. Arzneimittelforschung. 1996;15:547-551.
31. Tsuboi R, Rifkin DB. Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice. J Exp Med. 1990; 172:245-251.
32. Synergen Annual Report. Boulder, Colo: Synergen Inc: 1992.
33. Richard JL, Parer-Richard C, Daures JP. Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot: a pilot, randomized, double-blind, placebo-controlled study. Diabetes Care. 1995; 18:64-69.
34. Plate KH, Breier G, Millauer B, Ullrich A, Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res. 1993;53: 5822-5827.
35. Pierce GF, Vande Berg J, Rudolph R, Trapley J. Mustoe TA. Platelet derived growth factor and transforming growth factor beta and selectively modulate glycosaminoglycans, collagens, and myofibroblasts in excisional wounds. Am J Pathol. 1991;138:629-646.
36. Mustoe TA, Pierce GF, Thomanson A. Gramates P, Sporn MB, Devel TF. Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science. 1987;237:1333-1336.
37. Peters KG, De Vries C, Williams LT. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci U S A. 1993;90: 8915-8919.
38. Tuder RM, Flook BE, Voelkel NF. Increased gene expression for VEGF and the VEGF receptors KDR/ FIk and FIt in lungs exposed to acute or to chronic hypoxia: modulation of gene expression by nitric oxide. J Clin Invest. 1995;95:1798-1807.
39. Plate KH, Breir G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in gliomas in vivo. Nature. 1992; 359:845-848.
40. Wu L, Zhao LL, Davidson DO, Wee SC, Roth SI, Mustoe TA. Effect of hyperbaric oxygen and growth factors on rabbit ear ischemic ulcers. Arch Surg. 1994;129:1043-1049.
41. Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell. 1993;4: 1317-1326.