메뉴 건너뛰기




Volumn 78, Issue 6, 2010, Pages 561-568

Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate

Author keywords

children; pediatric kidney transplantation; transplantation; vascular endothelial growth factor

Indexed keywords

BROXURIDINE; CALCEIN; GROWTH HORMONE; MESSENGER RNA; RAPAMYCIN; SOMATOMEDIN C; VASCULOTROPIN;

EID: 77956226075     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.173     Document Type: Article
Times cited : (38)

References (34)
  • 1
    • 20844456618 scopus 로고    scopus 로고
    • Clinical application of sirolimus in renal transplantation: An update
    • Chueh SC, Kahan BD. Clinical application of sirolimus in renal transplantation: an update. Transpl Int 2005; 18: 261-277.
    • (2005) Transpl Int , vol.18 , pp. 261-277
    • Chueh, S.C.1    Kahan, B.D.2
  • 2
    • 0037184316 scopus 로고    scopus 로고
    • Kidney transplantation without calcineurin inhibitor drugs: A prospective, randomized trial of sirolimus versus cyclosporine
    • Flechner SM, Goldfarb D, Modlin C et al. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. Transplantation 2002; 74: 1070-1076.
    • (2002) Transplantation , vol.74 , pp. 1070-1076
    • Flechner, S.M.1    Goldfarb, D.2    Modlin, C.3
  • 3
    • 17844362979 scopus 로고    scopus 로고
    • Sirolimus-based therapy with or without cyclosporine: Long-term follow-up in renal transplant patients
    • Morales JM, Campistol JM, Kreis H et al. Sirolimus-based therapy with or without cyclosporine: long-term follow-up in renal transplant patients. Transplant proc 2005; 37: 693-696.
    • (2005) Transplant Proc , vol.37 , pp. 693-696
    • Morales, J.M.1    Campistol, J.M.2    Kreis, H.3
  • 4
    • 10744227990 scopus 로고    scopus 로고
    • Ten years of sirolimus therapy for human renal transplantation: The University of Texas at Houston experience
    • Kahan BD, Knight R, Schoenberg L et al. Ten years of sirolimus therapy for human renal transplantation: the University of Texas at Houston experience. Transplant Proc 2003; 35: 25s-34s.
    • (2003) Transplant Proc , vol.35
    • Kahan, B.D.1    Knight, R.2    Schoenberg, L.3
  • 5
    • 4043142865 scopus 로고    scopus 로고
    • Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Results from five multicenter studies
    • Mathew T, Kreis H, Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant 2004; 18: 446-449.
    • (2004) Clin Transplant , vol.18 , pp. 446-449
    • Mathew, T.1    Kreis, H.2    Friend, P.3
  • 6
    • 20144367584 scopus 로고    scopus 로고
    • Sirolimus for Kaposi's sarcoma in renal-transplant recipients
    • Stallone G, Schena A, Infante B. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352: 1317-1323.
    • (2005) N Engl J Med , vol.352 , pp. 1317-1323
    • Stallone, G.1    Schena, A.2    Infante, B.3
  • 7
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • For the RECORD-1 Study Group
    • Motzer RJ, Escudier B, Oudard S, et al., for the RECORD-1 Study Group. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372: 449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 8
    • 38049169559 scopus 로고    scopus 로고
    • Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    • Bissler JJ, McCormack FX, Young LR et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008; 358: 140-151.
    • (2008) N Engl J Med , vol.358 , pp. 140-151
    • Bissler, J.J.1    McCormack, F.X.2    Young, L.R.3
  • 9
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926-1945.
    • (2004) Genes Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 10
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3
  • 11
    • 64049111999 scopus 로고    scopus 로고
    • Sirolimus to replace calcineurin inhibitors? Too early yet
    • Cravedi P, Ruggenenti P, Remuzzi G. Sirolimus to replace calcineurin inhibitors? Too early yet. Lancet 2009; 373: 1235-1236.
    • (2009) Lancet , vol.373 , pp. 1235-1236
    • Cravedi, P.1    Ruggenenti, P.2    Remuzzi, G.3
  • 13
    • 34250012874 scopus 로고    scopus 로고
    • Rapamycin retards growth and causes marked alterations in the growth plate of young rats
    • Alvarez-Garcia O, Carbajo-Pérez E, Garcia E et al. Rapamycin retards growth and causes marked alterations in the growth plate of young rats. Pediatr Nephrol 2007; 22: 954-961.
    • (2007) Pediatr Nephrol , vol.22 , pp. 954-961
    • Alvarez-Garcia, O.1    Carbajo-Pérez, E.2    Garcia, E.3
  • 14
    • 63049094292 scopus 로고    scopus 로고
    • Bone growth during rapamycin therapy in young rats
    • Sanchez CP, He YZ. Bone growth during rapamycin therapy in young rats. BMC Pediatr 2009; 9: 3.
    • (2009) BMC Pediatr , vol.9 , pp. 3
    • Sanchez, C.P.1    He, Y.Z.2
  • 15
    • 68849083243 scopus 로고    scopus 로고
    • The effect of rapamycin on bone growth in rabbits
    • Phornphutkul C, Lee M, Voigt C et al. The effect of rapamycin on bone growth in rabbits. J Orthop Res 2009; 27: 1157-1161.
    • (2009) J Orthop Res , vol.27 , pp. 1157-1161
    • Phornphutkul, C.1    Lee, M.2    Voigt, C.3
  • 16
    • 57649096459 scopus 로고    scopus 로고
    • MTOR-what does it do?
    • Hall MN. mTOR-what does it do? Transplant Proc 2008; 40: 5s-58s.
    • (2008) Transplant Proc , vol.40
    • Hall, M.N.1
  • 17
    • 0035735902 scopus 로고    scopus 로고
    • Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
    • Rommel C, Bodine SC, Clarke BA et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 2001; 3: 1009-1013.
    • (2001) Nat Cell Biol , vol.3 , pp. 1009-1013
    • Rommel, C.1    Bodine, S.C.2    Clarke, B.A.3
  • 18
    • 23644450412 scopus 로고    scopus 로고
    • IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK
    • Starkman BG, Cravero JD, Delcarlo M et al. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J 2005; 389: 723-729.
    • (2005) Biochem J , vol.389 , pp. 723-729
    • Starkman, B.G.1    Cravero, J.D.2    Delcarlo, M.3
  • 19
    • 0030934472 scopus 로고    scopus 로고
    • The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways
    • Coolican SA, Samuel DS, Ewton DZ et al. The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J Biol Chem 1997; 272: 6653-6662.
    • (1997) J Biol Chem , vol.272 , pp. 6653-6662
    • Coolican, S.A.1    Samuel, D.S.2    Ewton, D.Z.3
  • 20
    • 0346057833 scopus 로고    scopus 로고
    • Systemic and local regulation of the growth plate
    • van der Eerden BC, Karperien M, Wit JM. Systemic and local regulation of the growth plate. Endocr Rev 2003; 24: 782-801.
    • (2003) Endocr Rev , vol.24 , pp. 782-801
    • Van Der Eerden, B.C.1    Karperien, M.2    Wit, J.M.3
  • 21
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber HP, Vu TH, Ryan AM et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999; 5: 623-628.
    • (1999) Nat Med , vol.5 , pp. 623-628
    • Gerber, H.P.1    Vu, T.H.2    Ryan, A.M.3
  • 22
    • 33745242315 scopus 로고    scopus 로고
    • Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
    • Del Bufalo D, Ciuffreda L, Trisciuoglio D et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006; 66: 5549-5554.
    • (2006) Cancer Res , vol.66 , pp. 5549-5554
    • Del Bufalo, D.1    Ciuffreda, L.2    Trisciuoglio, D.3
  • 23
    • 0141705466 scopus 로고    scopus 로고
    • Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
    • El-Hashemite N, Walker V, Zhang H et al. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003; 63: 5173-5177.
    • (2003) Cancer Res , vol.63 , pp. 5173-5177
    • El-Hashemite, N.1    Walker, V.2    Zhang, H.3
  • 24
    • 0037336853 scopus 로고    scopus 로고
    • Rapamycin is an effective inhibitor of human renal cancer metastasis
    • Luan FL, Ding R, Sharma VK et al. Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney Int 2003; 63: 917-926.
    • (2003) Kidney Int , vol.63 , pp. 917-926
    • Luan, F.L.1    Ding, R.2    Sharma, V.K.3
  • 25
    • 34948815004 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass
    • Diekmann F, Rovira J, Carreras J et al. Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass. J Am Soc Nephrol 2007; 18: 2653-2660.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2653-2660
    • Diekmann, F.1    Rovira, J.2    Carreras, J.3
  • 26
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003; 9: 677-684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 27
    • 0035115801 scopus 로고    scopus 로고
    • The somatomedin hypothesis 2001
    • Le Roith D, Bondy C, Yakar S et al. The somatomedin hypothesis: 2001. Endocr Rev 2001; 22: 53-74.
    • (2001) Endocr Rev , vol.22 , pp. 53-74
    • Le Roith, D.1    Bondy, C.2    Yakar, S.3
  • 28
    • 22144494185 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFB)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways
    • Kiepe D, Ciarmatori S, Hoeflich A et al. Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFB)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology 2005; 146: 3096-3104.
    • (2005) Endocrinology , vol.146 , pp. 3096-3104
    • Kiepe, D.1    Ciarmatori, S.2    Hoeflich, A.3
  • 29
    • 66049155861 scopus 로고    scopus 로고
    • Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy
    • Bohensky J, Terkhorn SP, Freeman TA et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum 2009; 60: 1406-1415.
    • (2009) Arthritis Rheum , vol.60 , pp. 1406-1415
    • Bohensky, J.1    Terkhorn, S.P.2    Freeman, T.A.3
  • 30
    • 33745869072 scopus 로고    scopus 로고
    • Chondrocytes embedded in the epiphyseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis
    • Srinivas V, Shapiro IM. Chondrocytes embedded in the epiphyseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis. Autophagy 2006; 2: 215-216.
    • (2006) Autophagy , vol.2 , pp. 215-216
    • Srinivas, V.1    Shapiro, I.M.2
  • 31
    • 74949092824 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    • Ma J, Meng Y, Kwiatkowski DJ et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 2010; 120: 103-114.
    • (2010) J Clin Invest , vol.120 , pp. 103-114
    • Ma, J.1    Meng, Y.2    Kwiatkowski, D.J.3
  • 32
    • 33845235465 scopus 로고    scopus 로고
    • Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it
    • Molinos I, Santos F, Carbajo-Perez E et al. Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it. Kidney Int 2006; 70: 1955-1961.
    • (2006) Kidney Int , vol.70 , pp. 1955-1961
    • Molinos, I.1    Santos, F.2    Carbajo-Perez, E.3
  • 33
    • 69449094456 scopus 로고    scopus 로고
    • Alterations of growth plate and abnormal insulin-like growth factor i metabolism in growth-retarded hypokalemic rats: Effect of growth hormone treatment
    • Gil-Peña H, Garcia-Lopez E, Alvarez-Garcia O et al. Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth-retarded hypokalemic rats: effect of growth hormone treatment. Am J Physiol Renal Physiol 2009; 297: 639-645.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. 639-645
    • Gil-Peña, H.1    Garcia-Lopez, E.2    Alvarez-Garcia, O.3
  • 34
    • 34248663955 scopus 로고    scopus 로고
    • The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on
    • Chomczynski P, Sacchi N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat Protoc 2006; 1: 581-585.
    • (2006) Nat Protoc , vol.1 , pp. 581-585
    • Chomczynski, P.1    Sacchi, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.