-
1
-
-
20844456618
-
Clinical application of sirolimus in renal transplantation: An update
-
Chueh SC, Kahan BD. Clinical application of sirolimus in renal transplantation: an update. Transpl Int 2005; 18: 261-277.
-
(2005)
Transpl Int
, vol.18
, pp. 261-277
-
-
Chueh, S.C.1
Kahan, B.D.2
-
2
-
-
0037184316
-
Kidney transplantation without calcineurin inhibitor drugs: A prospective, randomized trial of sirolimus versus cyclosporine
-
Flechner SM, Goldfarb D, Modlin C et al. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. Transplantation 2002; 74: 1070-1076.
-
(2002)
Transplantation
, vol.74
, pp. 1070-1076
-
-
Flechner, S.M.1
Goldfarb, D.2
Modlin, C.3
-
3
-
-
17844362979
-
Sirolimus-based therapy with or without cyclosporine: Long-term follow-up in renal transplant patients
-
Morales JM, Campistol JM, Kreis H et al. Sirolimus-based therapy with or without cyclosporine: long-term follow-up in renal transplant patients. Transplant proc 2005; 37: 693-696.
-
(2005)
Transplant Proc
, vol.37
, pp. 693-696
-
-
Morales, J.M.1
Campistol, J.M.2
Kreis, H.3
-
4
-
-
10744227990
-
Ten years of sirolimus therapy for human renal transplantation: The University of Texas at Houston experience
-
Kahan BD, Knight R, Schoenberg L et al. Ten years of sirolimus therapy for human renal transplantation: the University of Texas at Houston experience. Transplant Proc 2003; 35: 25s-34s.
-
(2003)
Transplant Proc
, vol.35
-
-
Kahan, B.D.1
Knight, R.2
Schoenberg, L.3
-
5
-
-
4043142865
-
Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: Results from five multicenter studies
-
Mathew T, Kreis H, Friend P. Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transplant 2004; 18: 446-449.
-
(2004)
Clin Transplant
, vol.18
, pp. 446-449
-
-
Mathew, T.1
Kreis, H.2
Friend, P.3
-
6
-
-
20144367584
-
Sirolimus for Kaposi's sarcoma in renal-transplant recipients
-
Stallone G, Schena A, Infante B. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N Engl J Med 2005; 352: 1317-1323.
-
(2005)
N Engl J Med
, vol.352
, pp. 1317-1323
-
-
Stallone, G.1
Schena, A.2
Infante, B.3
-
7
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
For the RECORD-1 Study Group
-
Motzer RJ, Escudier B, Oudard S, et al., for the RECORD-1 Study Group. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372: 449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
8
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler JJ, McCormack FX, Young LR et al. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 2008; 358: 140-151.
-
(2008)
N Engl J Med
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
McCormack, F.X.2
Young, L.R.3
-
9
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
10
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
Guba M, von Breitenbuch P, Steinbauer M et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-135.
-
(2002)
Nat Med
, vol.8
, pp. 128-135
-
-
Guba, M.1
Von Breitenbuch, P.2
Steinbauer, M.3
-
11
-
-
64049111999
-
Sirolimus to replace calcineurin inhibitors? Too early yet
-
Cravedi P, Ruggenenti P, Remuzzi G. Sirolimus to replace calcineurin inhibitors? Too early yet. Lancet 2009; 373: 1235-1236.
-
(2009)
Lancet
, vol.373
, pp. 1235-1236
-
-
Cravedi, P.1
Ruggenenti, P.2
Remuzzi, G.3
-
13
-
-
34250012874
-
Rapamycin retards growth and causes marked alterations in the growth plate of young rats
-
Alvarez-Garcia O, Carbajo-Pérez E, Garcia E et al. Rapamycin retards growth and causes marked alterations in the growth plate of young rats. Pediatr Nephrol 2007; 22: 954-961.
-
(2007)
Pediatr Nephrol
, vol.22
, pp. 954-961
-
-
Alvarez-Garcia, O.1
Carbajo-Pérez, E.2
Garcia, E.3
-
14
-
-
63049094292
-
Bone growth during rapamycin therapy in young rats
-
Sanchez CP, He YZ. Bone growth during rapamycin therapy in young rats. BMC Pediatr 2009; 9: 3.
-
(2009)
BMC Pediatr
, vol.9
, pp. 3
-
-
Sanchez, C.P.1
He, Y.Z.2
-
15
-
-
68849083243
-
The effect of rapamycin on bone growth in rabbits
-
Phornphutkul C, Lee M, Voigt C et al. The effect of rapamycin on bone growth in rabbits. J Orthop Res 2009; 27: 1157-1161.
-
(2009)
J Orthop Res
, vol.27
, pp. 1157-1161
-
-
Phornphutkul, C.1
Lee, M.2
Voigt, C.3
-
16
-
-
57649096459
-
MTOR-what does it do?
-
Hall MN. mTOR-what does it do? Transplant Proc 2008; 40: 5s-58s.
-
(2008)
Transplant Proc
, vol.40
-
-
Hall, M.N.1
-
17
-
-
0035735902
-
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
-
Rommel C, Bodine SC, Clarke BA et al. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 2001; 3: 1009-1013.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1009-1013
-
-
Rommel, C.1
Bodine, S.C.2
Clarke, B.A.3
-
18
-
-
23644450412
-
IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK
-
Starkman BG, Cravero JD, Delcarlo M et al. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK. Biochem J 2005; 389: 723-729.
-
(2005)
Biochem J
, vol.389
, pp. 723-729
-
-
Starkman, B.G.1
Cravero, J.D.2
Delcarlo, M.3
-
19
-
-
0030934472
-
The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways
-
Coolican SA, Samuel DS, Ewton DZ et al. The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J Biol Chem 1997; 272: 6653-6662.
-
(1997)
J Biol Chem
, vol.272
, pp. 6653-6662
-
-
Coolican, S.A.1
Samuel, D.S.2
Ewton, D.Z.3
-
21
-
-
0033027858
-
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
-
Gerber HP, Vu TH, Ryan AM et al. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 1999; 5: 623-628.
-
(1999)
Nat Med
, vol.5
, pp. 623-628
-
-
Gerber, H.P.1
Vu, T.H.2
Ryan, A.M.3
-
22
-
-
33745242315
-
Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
-
Del Bufalo D, Ciuffreda L, Trisciuoglio D et al. Antiangiogenic potential of the mammalian target of rapamycin inhibitor temsirolimus. Cancer Res 2006; 66: 5549-5554.
-
(2006)
Cancer Res
, vol.66
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
-
23
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite N, Walker V, Zhang H et al. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003; 63: 5173-5177.
-
(2003)
Cancer Res
, vol.63
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
-
24
-
-
0037336853
-
Rapamycin is an effective inhibitor of human renal cancer metastasis
-
Luan FL, Ding R, Sharma VK et al. Rapamycin is an effective inhibitor of human renal cancer metastasis. Kidney Int 2003; 63: 917-926.
-
(2003)
Kidney Int
, vol.63
, pp. 917-926
-
-
Luan, F.L.1
Ding, R.2
Sharma, V.K.3
-
25
-
-
34948815004
-
Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass
-
Diekmann F, Rovira J, Carreras J et al. Mammalian target of rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass. J Am Soc Nephrol 2007; 18: 2653-2660.
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 2653-2660
-
-
Diekmann, F.1
Rovira, J.2
Carreras, J.3
-
26
-
-
0038037735
-
Regulation of angiogenesis by hypoxia: Role of the HIF system
-
Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003; 9: 677-684.
-
(2003)
Nat Med
, vol.9
, pp. 677-684
-
-
Pugh, C.W.1
Ratcliffe, P.J.2
-
27
-
-
0035115801
-
The somatomedin hypothesis 2001
-
Le Roith D, Bondy C, Yakar S et al. The somatomedin hypothesis: 2001. Endocr Rev 2001; 22: 53-74.
-
(2001)
Endocr Rev
, vol.22
, pp. 53-74
-
-
Le Roith, D.1
Bondy, C.2
Yakar, S.3
-
28
-
-
22144494185
-
Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFB)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways
-
Kiepe D, Ciarmatori S, Hoeflich A et al. Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFB)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology 2005; 146: 3096-3104.
-
(2005)
Endocrinology
, vol.146
, pp. 3096-3104
-
-
Kiepe, D.1
Ciarmatori, S.2
Hoeflich, A.3
-
29
-
-
66049155861
-
Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy
-
Bohensky J, Terkhorn SP, Freeman TA et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum 2009; 60: 1406-1415.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 1406-1415
-
-
Bohensky, J.1
Terkhorn, S.P.2
Freeman, T.A.3
-
30
-
-
33745869072
-
Chondrocytes embedded in the epiphyseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis
-
Srinivas V, Shapiro IM. Chondrocytes embedded in the epiphyseal growth plates of long bones undergo autophagy prior to the induction of osteogenesis. Autophagy 2006; 2: 215-216.
-
(2006)
Autophagy
, vol.2
, pp. 215-216
-
-
Srinivas, V.1
Shapiro, I.M.2
-
31
-
-
74949092824
-
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
-
Ma J, Meng Y, Kwiatkowski DJ et al. Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest 2010; 120: 103-114.
-
(2010)
J Clin Invest
, vol.120
, pp. 103-114
-
-
Ma, J.1
Meng, Y.2
Kwiatkowski, D.J.3
-
32
-
-
33845235465
-
Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it
-
Molinos I, Santos F, Carbajo-Perez E et al. Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it. Kidney Int 2006; 70: 1955-1961.
-
(2006)
Kidney Int
, vol.70
, pp. 1955-1961
-
-
Molinos, I.1
Santos, F.2
Carbajo-Perez, E.3
-
33
-
-
69449094456
-
Alterations of growth plate and abnormal insulin-like growth factor i metabolism in growth-retarded hypokalemic rats: Effect of growth hormone treatment
-
Gil-Peña H, Garcia-Lopez E, Alvarez-Garcia O et al. Alterations of growth plate and abnormal insulin-like growth factor I metabolism in growth-retarded hypokalemic rats: effect of growth hormone treatment. Am J Physiol Renal Physiol 2009; 297: 639-645.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
, pp. 639-645
-
-
Gil-Peña, H.1
Garcia-Lopez, E.2
Alvarez-Garcia, O.3
-
34
-
-
34248663955
-
The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on
-
Chomczynski P, Sacchi N. The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat Protoc 2006; 1: 581-585.
-
(2006)
Nat Protoc
, vol.1
, pp. 581-585
-
-
Chomczynski, P.1
Sacchi, N.2
|