Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis

Biochemical Journal

Volumn 417, Issue 1, 2009, Pages 247-256

  Santana, Débora P ^a   Faria, Priscila A ^a   Paredes Gamero, Edgar J ^b   Caires, Antonio C F ^a   Nantes, Iseli L ^a   Rodrigues, Tiago ^a  

^a UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Apoptosis; Cytochrome c release; Mitochondrial permeabilization; Palladacycles; Rat liver mitochondria; Thiol cross linkage

Indexed keywords

APOPTOSIS; CYTOCHROME C RELEASE; MITOCHONDRIAL PERMEABILIZATION; PALLADACYCLES; RAT LIVER MITOCHONDRIA; THIOL CROSS-LINKAGE;

CALCIUM; CELL CULTURE; CELL DEATH; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LIVER; MEMBRANES; MITOCHONDRIA; OXIDATION; PROTEINS; REACTION KINETICS; TISSUE CULTURE;

CELL MEMBRANES;

ANTINEOPLASTIC AGENT; CALCIUM ION; CYTOCHROME C; GLUTATHIONE; MITOCHONDRIAL PROTEIN; PALLADACYCLE DERIVATIVE; THIOL; UNCLASSIFIED DRUG; HETEROCYCLIC COMPOUND; MEMBRANE PROTEIN; N,N DIMETHYL 1 PHENETHYLAMINE; N,N-DIMETHYL-1-PHENETHYLAMINE; PALLADIUM; PHENETHYLAMINE DERIVATIVE; THIOL DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; DISULFIDE BOND; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME RELEASE; LIVER CELL CARCINOMA; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; FLOW CYTOMETRY; INFRARED SPECTROSCOPY; METABOLISM; OXIDATION REDUCTION REACTION; PERMEABILITY; PHYSIOLOGY; SYNTHESIS; TUMOR CELL LINE;

MURINAE; RATTUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES C; FLOW CYTOMETRY; HETEROCYCLIC COMPOUNDS; MEMBRANE PROTEINS; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MITOCHONDRIAL SWELLING; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PALLADIUM; PERMEABILITY; PHENETHYLAMINES; RATS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SULFHYDRYL COMPOUNDS;

EID: 58249086504     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20080972     Document Type: Article

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