Adrenomedullin reduces gender-dependent loss of hypotensive cerebrovasodilation after newborn brain injury through activation of ATP-dependent K channels

Journal of Cerebral Blood Flow and Metabolism

Volumn 27, Issue 10, 2007, Pages 1702-1709

  Armstead, William M ^a   Vavilala, Monica S ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Autoregulation; Brain injury; Cerebral circulation; Newborn; Signal transduction

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENOMEDULLIN; GLIBENCLAMIDE; IBERIOTOXIN; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BRAIN INJURY; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; FEMALE; GENDER; HYPOTENSION; MALE; MEMBRANE CHANNEL; NONHUMAN; PIA MATER; PRIORITY JOURNAL; PROTEIN FUNCTION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SWINE; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ADRENOMEDULLIN; ANIMALS; ANIMALS, NEWBORN; ARTERIES; BRAIN INJURIES; FEMALE; GLYBURIDE; HYPOTENSION; MALE; PEPTIDES; POTASSIUM CHANNELS; SEX CHARACTERISTICS; SWINE; VASODILATION;

EID: 34748880741     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600473     Document Type: Article

References (31)

1. Armstead WM (1996) The role of ATP-sensitive K channels in cGMP-mediated pial artery vaso-dilation. Am J Physiol 270:H423-6
2. Armstead WM (1997a) Brain injury impairs ATP-sensitive K channel function in piglet cerebral arteries. Stroke 28:2273-80
3. Armstead WM (1997b) Role of impaired camp and calcium sensitive K channel function in altered cerebral hemodynamics following brain injury. Brain Res 768:177-84
4. Armstead WM (1998) ATP-dependent K channel activation reduces loss of opioid dilation after brain injury. Am J Physiol 274:H1674-83
5. ca channel activation. Brain Res 816:158-64
6. Armstead WM (1999b) Role of endothelin-1 in age dependent cerebrovascular hypotensive responses after brain injury. Am J Physiol 274:H1884-94
7. Armstead WM (2005) Age and cerebral circulation. Pathophysiology 12:5-15
8. Bayir H, Kagan VE, Tyurina YY, Tyurin V, Ruppel RA, Adelson PD, Graham SH, Janesko K, Clark RSB, Kochaneck PM (2002) Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children. Ped Res 51:571-8
9. Coates BM, Vavilala MS, Mack CD, Muangman S, Suz P, Sharar SR, Bulger E, Lam AM (2005) Influence of definition and location of hypotension on outcome following severe pediatric traumatic brain injury. Crit Care Med 33:2645-50
10. Du L, Bayir H, Lai Y, Zhang X, Kochaneck PM, Watkins SC, Graham SH, Clark RSB (2004) Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem 279:38563-70
11. Fan P, Yamauchi T, Noble LJ, Ferriero DM (2003) Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma 20:437-45
12. Faraci FM, Heistad DD (1998) Regulation of the cerebral circulation and role of endothelium and potassium channels. Physiol Rev 78:53-97
13. Gennarelli TA (1994) Animate models of human head injury. J Neurotrauma 11:357-68
14. Kanu A, Whitfield J, Leffler CW (2006) Carbon monoxide contributes to hypotension-induced cerebrovascular vasodilation in piglets. Am J Physiol 291:H2409-14
15. Lang MG, Paterno R, Faraci FM, Heistad DD (1997) Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles. Stroke 28:181-5
16. Langlois JA, Rutland-Brown W, Thomas KE (2005) The incidence of traumatic brain injury among children in the United States: differences by race 1. J Head Trauma Rehabil 20:229-38
17. McIntosh TK, Vink R, Noble L, Yamakami I, Fernyak S, Soares H, Faden AL (1989) Traumatic brain injury in the rat: characterization of a lateral fluid percussion model. Neuroscience 28:233-44
18. 2+-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone. Trends Cardiovasc Med 3:54-60
19. Nelson MT, Quayle JM (1995) Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 268:C799-822
20. Robertson CL, Minamino N, Ruppel RA, Kangawa K, Wisniewski R, Tsuji T, Janesko KL, Ohta H, Adelson PD, Marion DW, Kochanek PM (2001) Increased adrenomedullin in cerebro-spinal fluid after traumatic brain injury in infants and children. J Neurotrauma 18:861-8
21. Rodriguez JG (1990) Childhood injuries in the United States. A priority issue. Am J Dis Child 144:625-6
22. ATP channels. Eur J Pharm 359:151-9
23. Terata K, Miura H, Liu Y, Loberiza F, Gutterman DG (2000) Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K channels. Am J Physiol 279:H2620-6
24. Tsuji M, duPlessis A, Taylor G, Crocker R, Vople JJ (1998) Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets. Pediatr Res 44:591-5
25. Vavilala MS, Lee LA, Newell DW, Lam AM (2004) Cerebral autoregulation in children with traumatic brain injury. Pediatr Crit Care Med 5:257-63
26. Vavilala MS, Muangman S, Tontisirin N, Fisk D, Roscigno C, Mitchell P, Kirkness C, Zimmerman JJ, Chesnut R, Lam AM (2006) Impaired cerebral autoregulation and 6-month outcome in children with severe traumatic brain injury: Preliminary findings. Develop Neurosci 28:348-53
27. Wei EP, Dietrich WD, Povlishock JT, Naravari RM, Kontos HA (1980) Functional, morpho-logical, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ Res 46:37-47
28. Willis AP, Leffler CW (1999) NO and prostanoids: age dependence of hypercapnia and histamine-induced dilations of pig pial arterioles. Am J Physiol 277:H299-307
29. Willis AP, Leffler CW(2001) Endothelial NO and prostanoid involvement in newborn and juvenile pig pial arteriolar vasomotor responses. Am J Physiol 281:H2366-77
30. ca channels in newborn arteriole smooth muscle cells by increasing apparent Ca sensitivity of α subunits. Am J Physiol 286:H610-8
31. Zuckerman SL, Armstead WM, Hsu P, Shibata M, Leffler CW (1996) Age dependence of cerebrovascular response mechanisms in domestic pigs. Am J Physiol 271:H535-40