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Volumn 17, Issue 3, 2010, Pages 599-610

Identification of a paired box gene 8-peroxisome proliferator-activated receptor gamma (PAX8-PPARγ) rearrangement mosaicism in a patient with an autonomous functioning follicular thyroid carcinoma bearing an activating mutation in the TSH receptor

Author keywords

[No Author keywords available]

Indexed keywords

DNA; IODINE 131; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RNA; THYROTROPIN RECEPTOR; TRANSCRIPTION FACTOR PAX8; PAIRED BOX TRANSCRIPTION FACTOR; PAX8 PROTEIN, HUMAN;

EID: 77956223649     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1677/ERC-09-0069     Document Type: Article
Times cited : (15)

References (37)
  • 1
    • 29344463661 scopus 로고    scopus 로고
    • PAX8-perosisome proliferator-activated receptor γ (PPARγ) disrupts normal PAX8 or PPARγ transcriptional function and stimulates follicular thyroid cell growth
    • Au AYM, McBride C, Wilhelm KG Jr, Koenig RJ, Speller B, Cheung L, Messina M, Wentworth J, Tasevski V, Learoyd D et al. 2006 PAX8-perosisome proliferator-activated receptor γ (PPARγ) disrupts normal PAX8 or PPARγ transcriptional function and stimulates follicular thyroid cell growth. Endocrinology 147 367-376.
    • (2006) Endocrinology , vol.147 , pp. 367-376
    • Au, A.Y.M.1    McBride, C.2    Wilhelm Jr., K.G.3    Koenig, R.J.4    Speller, B.5    Cheung, L.6    Messina, M.7    Wentworth, J.8    Tasevski, V.9    Learoyd, D.10
  • 2
  • 3
    • 0344010653 scopus 로고    scopus 로고
    • kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation
    • DOI 10.1038/sj.onc.1207029
    • Bravo SB, Pampin S, Cameselle-Teijeiro J, Carneiro C, Dominguez F, Barreiro F & Alvarez CV 2003 TGF-beta- induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation. Oncogene 22 7819-7830. (Pubitemid 37485541)
    • (2003) Oncogene , vol.22 , Issue.49 , pp. 7819-7830
    • Bravo, S.B.1    Pampin, S.2    Cameselle-Teijeiro, J.3    Carneiro, C.4    Dominguez, F.5    Barreiro, F.6    Alvarez, C.V.7
  • 5
    • 0034487437 scopus 로고    scopus 로고
    • A Phe 486 thyrotropin receptor mutation in an autonomously functioning follicular carcinoma that was causing hyperthyroidism
    • Camacho P, Gordon D, Chiefari E, Yong S, DeJong S, Pitale S, Russo D & Filetti S 2000 A Phe 486 thyrotropin receptor mutation in an autonomously functioning follicular carcinoma that was causing hyperthyroidism. Thyroid 10 1009-1012. (Pubitemid 32104088)
    • (2000) Thyroid , vol.10 , Issue.11 , pp. 1009-1012
    • Camacho, P.1    Gordon, D.2    Chiefari, E.3    Yong, S.4    DeJong, S.5    Pitale, S.6    Russo, D.7    Filetti, S.8
  • 10
    • 0347717977 scopus 로고    scopus 로고
    • Two somatic TSH receptor mutations in a patient with toxic metastasising follicular thyroid carcinoma and non-functional lung metastases
    • DOI 10.1677/erc.0.0100591
    • Fuhrer D, Tannapfel A, Sabri O, Lamesch P & Paschke R 2003 Two somatic TSH receptor mutations in a patient with a toxic metastasising follicular thyroid carcinoma and non-functional lung metastases. Endocrine-Related Cancer 10 591-600. (Pubitemid 38094893)
    • (2003) Endocrine-Related Cancer , vol.10 , Issue.4 , pp. 591-600
    • Fuhrer, D.1    Tannapfel, A.2    Sabri, O.3    Lamesch, P.4    Paschke, R.5
  • 12
    • 0037444286 scopus 로고    scopus 로고
    • Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma
    • Houston KD, Copland JA, Broaddus RR, Gottardis MM, Fischer SM & Walker CL 2003 Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. Cancer Research 63 1221-1227.
    • (2003) Cancer Research , vol.63 , pp. 1221-1227
    • Houston, K.D.1    Copland, J.A.2    Broaddus, R.R.3    Gottardis, M.M.4    Fischer, S.M.5    Walker, C.L.6
  • 13
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • Kondo T, Ezzat S & Asa SL 2006 Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nature Reviews. Cancer 6 292-306.
    • (2006) Nature Reviews. Cancer , vol.6 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 15
    • 0033607019 scopus 로고    scopus 로고
    • Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells
    • Ludgate M, Gire V, Crisp M, Ajjan R, Weetman A, Ivan M & Wynford-Thomas D 1999 Contrasting effects of activating mutations of GalphaS and the thyrotropin receptor on proliferation and differentiation of thyroid follicular cells. Oncogene 18 4798-4807.
    • (1999) Oncogene , vol.18 , pp. 4798-4807
    • Ludgate, M.1    Gire, V.2    Crisp, M.3    Ajjan, R.4    Weetman, A.5    Ivan, M.6    Wynford-Thomas, D.7
  • 19
    • 0027166893 scopus 로고
    • The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: Structural studies of the TSH-R and the alpha-subunit of G(s) in human thyroid neoplasms
    • DOI 10.1210/jc.76.6.1446
    • Matsuo K, Friedman E, Gejman PV & Fagin JA 1993 The thyrotropin receptor (TSH-R) is not an oncogene for the thyroid tumors: structural studies of the TSH-R and the alpha-subunit of the Gs in human thyroid neoplasms. Journal of Clinical Endocrinology and Metabolism 76 1446-1451. (Pubitemid 23164359)
    • (1993) Journal of Clinical Endocrinology and Metabolism , vol.76 , Issue.6 , pp. 1446-1451
    • Matsuo, K.1    Friedman, E.2    Gejman, P.V.3    Fagin, J.A.4
  • 21
    • 33846421673 scopus 로고    scopus 로고
    • Congenital hypothyroid female Pax8-deficient mice are infertile despite thyroid hormone replacement therapy
    • DOI 10.1210/en.2006-1054
    • Mittag J, Winterhager E, Bauer K & Grümmer R 2007 Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy. Endocrinology 148 719-725. (Pubitemid 46143173)
    • (2007) Endocrinology , vol.148 , Issue.2 , pp. 719-725
    • Mittag, J.1    Winterhager, E.2    Bauer, K.3    Grummer, R.4
  • 22
    • 33745223872 scopus 로고    scopus 로고
    • Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH Receptor (T620I) and a mutation of the Ki-RAS (G12C) genes
    • DOI 10.1089/thy.2006.16.497
    • Niepomniszcze H, Suaez H, Pitoia F, Pignatta A, Danilowicz K, Manavela M, Elsner B & Bruno OD 2006 Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH receptor (T620I) and a mutation of the Ki-RAS (G12C) genes. Thyroid 16 497-503. (Pubitemid 43912154)
    • (2006) Thyroid , vol.16 , Issue.5 , pp. 497-503
    • Niepomniszcze, H.1    Suarez, H.2    Pitoia, F.3    Pignatta, A.4    Danilowicz, K.5    Manavela, M.6    Elsner, B.7    Bruno, O.D.8
  • 26
    • 56749156643 scopus 로고    scopus 로고
    • Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain
    • Galician Group for the Study of Toxic Multinodular Goitre
    • Palos-Paz F, Perez-Guerra O, Cameselle-Teijeiro J, Rueda-Chimeno C, Barreiro-Morandeira F, Lado-Abeal J & Galician Group for the Study of Toxic Multinodular Goitre 2008 Prevalence of mutations in TSHR, GNAS, PRKAR1A and RAS genes in a large series of toxic thyroid adenomas from Galicia, an iodine-deficient area in NW Spain. European Journal of Endocrinology 159 623-631.
    • (2008) European Journal of Endocrinology , vol.159 , pp. 623-631
    • Palos-Paz, F.1    Perez-Guerra, O.2    Cameselle-Teijeiro, J.3    Rueda-Chimeno, C.4    Barreiro-Morandeira, F.5    Lado-Abeal, J.6
  • 28
    • 33847057768 scopus 로고    scopus 로고
    • Minireview: The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis
    • DOI 10.1210/en.2006-0926
    • Reddi HV, McIver B, Grebe SKG & Eberhardt NL 2007 Minireview: the paired box-8/peroxisome proliferator- activated receptor-gamma oncogene in thyroid tumorogenesis. Endocrinology 148 932-935. (Pubitemid 46272776)
    • (2007) Endocrinology , vol.148 , Issue.3 , pp. 932-935
    • Reddi, H.V.1    McIver, B.2    Grebe, S.K.G.3    Eberhardt, N.L.4
  • 34
    • 0029799977 scopus 로고    scopus 로고
    • Structural studies of the thyrotropin receptor and G(s)alpha in human thyroid cancers: Low prevalence of mutations predicts infrequent involvement in malignant transformation
    • DOI 10.1210/jc.81.11.3898
    • Spambalg D, Sharifi N, Elisei R, Gross JL, Medeiros-Neto G & Fagin JA 1996 Structural studies of the thyrotropin receptor and Gsalpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation. Journal of Clinical Endocrinology and Metabolism 81 3898-3901. (Pubitemid 26380393)
    • (1996) Journal of Clinical Endocrinology and Metabolism , vol.81 , Issue.11 , pp. 3898-3901
    • Spambalg, D.1    Sharifi, N.2    Elisei, R.3    Gross, J.L.4    Medeiros-Neto, G.5    Fagin, J.A.6
  • 36
    • 0026743033 scopus 로고
    • The thyrotropin receptor and the regulation of thyrocyte function and growth
    • Vassar G & Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocrine Reviews 13 596-611.
    • (1992) Endocrine Reviews , vol.13 , pp. 596-611
    • Vassar, G.1    Dumont, J.E.2
  • 37
    • 0036789093 scopus 로고    scopus 로고
    • Mechanisms and consequences of somatic mosaicism in humans
    • Youssoufian H & Pyeritz RE 2002 Mechanisms and consequences of somatic mosaicism in humans. Nature Reviews. Genetics 3 748-758.
    • (2002) Nature Reviews. Genetics , vol.3 , pp. 748-758
    • Youssoufian, H.1    Pyeritz, R.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.