Structural studies of the thyrotropin receptor and G(s)α in human thyroid cancers: Low prevalence of mutations predicts infrequent involvement in malignant transformation

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 11, 1996, Pages 3898-3901

  Spambalg, Dorothea ^a   Sharifi, Nazy ^a   Elisei, Rossella ^a   Gross, Jorge L ^b   Medeiros Neto, Geraldo ^c   Fagin, James A ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; THYROTROPIN; THYROTROPIN RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; DNA REPAIR; DNA REPLICATION; EXON; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; METASTASIS; POINT MUTATION; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; THYROID ADENOMA; THYROID CANCER;

BASE SEQUENCE; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CODON; DNA PRIMERS; DNA, NEOPLASM; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; MALE; MIDDLE AGED; MOLECULAR STRUCTURE; MUTATION; POINT MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTORS, THYROTROPIN; THYROID NEOPLASMS;

EID: 0029799977     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.11.3898     Document Type: Article

References (20)

1. Dumont JE, Lamy F, Roger P, Maenhaut C. 1992 Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 72:667-697.
2. Kopp P, Van Sande J, Parma J, et al. 1995 Brief report: congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene. N Engl J Med. 332:150-154.
3. Duprez L, Parma J, Van Sande J, et al. 1994 Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism. Nat Genet. 7:396-401.
4. 2+ cascades. Mol Endocrinol. 9:725-733.
5. Parma J, Duprez L, Van Sande J, et al. 1993 Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature. 365:649-651.
6. Lyons J, Landis CA, Harsh G, et al. 1990 Two G protein oncogenes in human endocrine tumors. Science. 249:655-659.
7. O'Sullivan C, Barton CM, Staddon SL, Brown CL, Lemoine NR. 1991 Activating point mutations of the gsp oncogene in human thyroid adenomas. Mol Carcinog. 4:345-349.
8. Suarez HG, du Villard JA, Caillou B, Schlumberger M, Parmentier C, Monier R. 1991 gsp mutations in human thyroid tumours. Oncogene. 6:677-679.
9. Russo D, Arturi F, Wicker R, et al. 1995 Genetic alterations in thyroid hyperfunctioning adenomas. J Clin Endocrinol Metab. 80:1347-1351.
10. s and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340:692-696.
11. s in human thyroid neoplasms. J Clin Endocrinol Metab. 76:1446-1451.
12. Russo D, Arturi F, Schlumberger M, et al. 1996 Activating mutations of the TSH receptor in differentiated thyroid carcinomas. Oncogene. 11:1907-1911.
13. Paul SJ, Sisson JC. 1990 Thyrotoxicosis caused by thyroid cancer. Endocrinol Metab Clin North Am. 19:593-612.
14. 3 hyperthyroidism and thyroid cancer. Clin Endocrinol (Oxf). 16:121-125.
15. Gross JL, Moraes IV. 1996 Thyroid hormone-producing metastases in differentiated thyroid cancer. J Endocrinol Invest. 19:21-24.
16. Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang SH, Koeffler HP. 1993 High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest. 91:179-184.
17. Nagayama Y, Kaufman KD, Seto P, Rapoport B. 1989 Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun. 165:1184-1190.
18. sα gene. Proc Natl Acad Sci USA. 85:2081-2085.
19. Mazzaferri EL. 1993 Management of a solitary thyroid nodule [see comments] [Review]. N Engl J Med. 328:553-559.
20. Michiels FM, Caillou B, Talbot M, et al. 1994 Oncogenic potential of guanine nucleotide stimulatory factor a subunit in thyroid glands of transgenic mice. Proc Natl Acad Sci USA. 91:10488-10492.