메뉴 건너뛰기




Volumn 147, Issue 1, 2006, Pages 367-376

PAX8-peroxisome proliferator-activated receptor γ (PPARγ) disrupts normal PAX8 or PPARγ transcriptional function and stimulates follicular thyroid cell growth

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; COTRANSPORTER; DNA; HYBRID PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SODIUM IODIDE; THYMIDINE; THYROGLOBULIN; THYROID PEROXIDASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX8;

EID: 29344463661     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-0147     Document Type: Article
Times cited : (54)

References (61)
  • 7
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA 1995 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 270:12953-12956
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 15
    • 0028881603 scopus 로고
    • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
    • Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG, Rauscher 3rd FJ 1995 The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol 15:1522-1535
    • (1995) Mol Cell Biol , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1    Galili, N.2    Mukhopadhyay, S.3    Rovera, G.4    Bennicelli, J.5    Barr, F.G.6    Rauscher III, F.J.7
  • 16
  • 19
    • 0038642086 scopus 로고    scopus 로고
    • A dominant negative PPARγ mutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells
    • Park Y, Freedman BD, Lee EJ, Park S, Jameson JL 2003 A dominant negative PPAR γmutant shows altered cofactor recruitment and inhibits adipogenesis in 3T3-L1 cells. Diabetologia 46:365-377
    • (2003) Diabetologia , vol.46 , pp. 365-377
    • Park, Y.1    Freedman, B.D.2    Lee, E.J.3    Park, S.4    Jameson, J.L.5
  • 21
    • 0030988565 scopus 로고    scopus 로고
    • Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors
    • Yoh SM, Chatterjee VK, Privalsky ML 1997 Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors. Mol Endocrinol 11:470-480
    • (1997) Mol Endocrinol , vol.11 , pp. 470-480
    • Yoh, S.M.1    Chatterjee, V.K.2    Privalsky, M.L.3
  • 22
    • 0032546017 scopus 로고    scopus 로고
    • Role of the histone deacetylase complex in acute promyelocytic leukaemia
    • Lin RJ, Nagy L, Inoue S, Shao W, Miller Jr WH, Evans RM 1998 Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature 391:811-814
    • (1998) Nature , vol.391 , pp. 811-814
    • Lin, R.J.1    Nagy, L.2    Inoue, S.3    Shao, W.4    Miller Jr., W.H.5    Evans, R.M.6
  • 25
    • 0035019640 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptor γ inhibit growth and induce apoptosis of human papillary thyroid carcinoma cells
    • Ohta K, Endo T, Haraguchi K, Hershman JM, Onaya T 2001 Ligands for peroxisome proliferator-activated receptor inhibit γ growth and induce apoptosis of human papillary thyroid carcinoma cells. J Clin Endocrinol Metab 86:2170-2177
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2170-2177
    • Ohta, K.1    Endo, T.2    Haraguchi, K.3    Hershman, J.M.4    Onaya, T.5
  • 30
    • 0027441203 scopus 로고
    • Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties
    • Kozmik Z, Kurzbauer R, Dorfler P, Busslinger M 1993 Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties. Mol Cell Biol 13:6024-6035
    • (1993) Mol Cell Biol , vol.13 , pp. 6024-6035
    • Kozmik, Z.1    Kurzbauer, R.2    Dorfler, P.3    Busslinger, M.4
  • 31
    • 0035202331 scopus 로고    scopus 로고
    • A unique combination of transcription factors controls differentiation of thyroid cells
    • Damante G, Tell G, Di Lauro R 2001 A unique combination of transcription factors controls differentiation of thyroid cells. Prog Nucleic Acids Res Mol Biol 66:307-356
    • (2001) Prog Nucleic Acids Res Mol Biol , vol.66 , pp. 307-356
    • Damante, G.1    Tell, G.2    Di Lauro, R.3
  • 32
    • 0037474242 scopus 로고    scopus 로고
    • The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription
    • Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M 2003 The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem 278:3395-3402
    • (2003) J Biol Chem , vol.278 , pp. 3395-3402
    • Di Palma, T.1    Nitsch, R.2    Mascia, A.3    Nitsch, L.4    Di Lauro, R.5    Zannini, M.6
  • 33
    • 0034894005 scopus 로고    scopus 로고
    • Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene
    • Espinoza CR, Schmitt TL, Loos U 2001 Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. J Mol Endocrinol 27:59-67
    • (2001) J Mol Endocrinol , vol.27 , pp. 59-67
    • Espinoza, C.R.1    Schmitt, T.L.2    Loos, U.3
  • 36
    • 0033049567 scopus 로고    scopus 로고
    • The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription
    • Ohno M, Zannini M, Levy O, Carrasco N, di Lauro R 1999 The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription. Mol Cell Biol 19:2051-2060
    • (1999) Mol Cell Biol , vol.19 , pp. 2051-2060
    • Ohno, M.1    Zannini, M.2    Levy, O.3    Carrasco, N.4    Di Lauro, R.5
  • 39
    • 0032566143 scopus 로고    scopus 로고
    • A new tool for efficient transfection of dog and human thyrocytes in primary culture
    • Uyttersprot N, Costagliola S, Miot F 1998 A new tool for efficient transfection of dog and human thyrocytes in primary culture. Mol Cell Endocrinol 142:35-39
    • (1998) Mol Cell Endocrinol , vol.142 , pp. 35-39
    • Uyttersprot, N.1    Costagliola, S.2    Miot, F.3
  • 40
    • 0036215398 scopus 로고    scopus 로고
    • The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay
    • Miccadei S, De Leo R, Zammarchi E, Natali PG, Civitareale D 2002 The synergistic activity of thyroid transcription factor 1 and Pax 8 relies on the promoter/enhancer interplay. Mol Endocrinol 16:837-846
    • (2002) Mol Endocrinol , vol.16 , pp. 837-846
    • Miccadei, S.1    De Leo, R.2    Zammarchi, E.3    Natali, P.G.4    Civitareale, D.5
  • 41
    • 0035125091 scopus 로고    scopus 로고
    • Transcriptional regulation of the human sodium/iodide symporter gene by Pax8 and TTF-1
    • Schmitt TL, Espinoza CR, Loos U 2001 Transcriptional regulation of the human sodium/iodide symporter gene by Pax8 and TTF-1. Exp Clin Endocrinol Diabetes 109:27-31
    • (2001) Exp Clin Endocrinol Diabetes , vol.109 , pp. 27-31
    • Schmitt, T.L.1    Espinoza, C.R.2    Loos, U.3
  • 42
    • 0031904175 scopus 로고    scopus 로고
    • The Fischer rat thyroid cell line FRTL-5 exhibits a nondiploid karyotype
    • Tasevski V, Benn D, Peters G, Luttrell B, Simpson A 1998 The Fischer rat thyroid cell line FRTL-5 exhibits a nondiploid karyotype. Thyroid 8:623-626
    • (1998) Thyroid , vol.8 , pp. 623-626
    • Tasevski, V.1    Benn, D.2    Peters, G.3    Luttrell, B.4    Simpson, A.5
  • 44
    • 0029731662 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
    • Lemberger T, Desvergne B, Wahli W 1996 Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 12:335-363
    • (1996) Annu Rev Cell Dev Biol , vol.12 , pp. 335-363
    • Lemberger, T.1    Desvergne, B.2    Wahli, W.3
  • 45
    • 0004954085 scopus 로고
    • Culture of hormone-dependent functional epithelial cells from rat thyroids
    • USA
    • Ambesi-Impiombato FS, Parks LA, Coon HG 1980 Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc Natl Acad Sci USA 77:3455-3459
    • (1980) Proc Natl Acad Sci , vol.77 , pp. 3455-3459
    • Ambesi-Impiombato, F.S.1    Parks, L.A.2    Coon, H.G.3
  • 47
    • 0038614904 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ is frequently down-regulated in a diversity of sporadic nonmedullary thyroid carcinomas
    • Aldred MA, Morrison C, Gimm O, Hoang-Vu C, Krause U, Dralle H, Jhiang S, Eng C 2003 Peroxisome proliferator-activated receptor γ is frequently down-regulated in a diversity of sporadic nonmedullary thyroid carcinomas. Oncogene 22:3412-3416
    • (2003) Oncogene , vol.22 , pp. 3412-3416
    • Aldred, M.A.1    Morrison, C.2    Gimm, O.3    Hoang-Vu, C.4    Krause, U.5    Dralle, H.6    Jhiang, S.7    Eng, C.8
  • 48
    • 4344592171 scopus 로고    scopus 로고
    • Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ-negative thyroid tumors PAX8-PPARγ rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses
    • Marques AR, Espadinha C, Frias MJ, Roque L, Catarino AL, Sobrinho LG, Leite V 2004 Underexpression of peroxisome proliferator-activated receptor (PPAR)γ in PAX8/PPARγ-negative thyroid tumors PAX8-PPARγ rearrangement in thyroid tumors: RT-PCR and immunohistochemical analyses. Br J Cancer 91:732-738
    • (2004) Br J Cancer , vol.91 , pp. 732-738
    • Marques, A.R.1    Espadinha, C.2    Frias, M.J.3    Roque, L.4    Catarino, A.L.5    Sobrinho, L.G.6    Leite, V.7
  • 50
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63:1454-1457
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 51
    • 0031941912 scopus 로고    scopus 로고
    • Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
    • He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP 1998 Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL. Nat Genet 18:126-135
    • (1998) Nat Genet , vol.18 , pp. 126-135
    • He, L.Z.1    Guidez, F.2    Tribioli, C.3    Peruzzi, D.4    Ruthardt, M.5    Zelent, A.6    Pandolfi, P.P.7
  • 53
    • 0036910932 scopus 로고    scopus 로고
    • Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using trichostatin A, a histone deacetylase inhibitor
    • Zarnegar R, Brunaud L, Kanauchi H, Wong M, Fung M, Ginzinger D, Duh QY, Clark OH 2002 Increasing the effectiveness of radioactive iodine therapy in the treatment of thyroid cancer using trichostatin A, a histone deacetylase inhibitor. Surgery 132:984-990
    • (2002) Surgery , vol.132 , pp. 984-990
    • Zarnegar, R.1    Brunaud, L.2    Kanauchi, H.3    Wong, M.4    Fung, M.5    Ginzinger, D.6    Duh, Q.Y.7    Clark, O.H.8
  • 56
    • 2542458413 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors restore radioiodide uptake and retention in poorly differentiated and anaplastic thyroid cancer cells by expression of the sodium/iodide symporter thyroperoxidase and thyroglobulin
    • Furuya F, Shimura H, Suzuki H, Taki K, Ohta K, Haraguchi K, Onaya T, Endo T, Kobayashi T 2004 Histone deacetylase inhibitors restore radioiodide uptake and retention in poorly differentiated and anaplastic thyroid cancer cells by expression of the sodium/iodide symporter thyroperoxidase and thyroglobulin. Endocrinology 145:2865-2875
    • (2004) Endocrinology , vol.145 , pp. 2865-2875
    • Furuya, F.1    Shimura, H.2    Suzuki, H.3    Taki, K.4    Ohta, K.5    Haraguchi, K.6    Onaya, T.7    Endo, T.8    Kobayashi, T.9
  • 57
    • 0035023260 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells
    • Greenberg VL, Williams JM, Cogswell JP, Mendenhall M, Zimmer SG 2001 Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. Thyroid 11:315-325
    • (2001) Thyroid , vol.11 , pp. 315-325
    • Greenberg, V.L.1    Williams, J.M.2    Cogswell, J.P.3    Mendenhall, M.4    Zimmer, S.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.