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Volumn 5, Issue 6, 2010, Pages

Employing information theoretic measures and mutagenesis to identify residues critical for drug-proton antiport function in mdr1p of Candida albicans

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ALANINE; ANISOMYCIN; CERULENIN; CYCLOHEXIMIDE; FLUCONAZOLE; LEUCINE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; DRUG; GLYCOPROTEIN P; PROTON;

EID: 77956223495     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011041     Document Type: Article
Times cited : (17)

References (31)
  • 1
    • 10444285332 scopus 로고    scopus 로고
    • Multidrug resistance in yeast Candida
    • Prasad R, Kapoor K (2005) Multidrug resistance in yeast Candida. Int Rev Cytol 242: 215-248.
    • (2005) Int Rev Cytol , vol.242 , pp. 215-248
    • Prasad, R.1    Kapoor, K.2
  • 2
    • 27544514993 scopus 로고    scopus 로고
    • Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans
    • Gaur M, Choudhury D, Prasad R (2005) Complete inventory of ABC proteins in human pathogenic yeast, Candida albicans. J Mol Microbiol Biotechnol 9: 3-15.
    • (2005) J Mol Microbiol Biotechnol , vol.9 , pp. 3-15
    • Gaur, M.1    Choudhury, D.2    Prasad, R.3
  • 4
    • 24044514014 scopus 로고    scopus 로고
    • Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: Identification of amino acid residues critical for drug efflux
    • Saini P, Prasad T, Gaur NA, Shukla S, Jha S, et al. (2005) Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux. J Antimicrob Chemother 56: 77-86.
    • (2005) J Antimicrob Chemother , vol.56 , pp. 77-86
    • Saini, P.1    Prasad, T.2    Gaur, N.A.3    Shukla, S.4    Jha, S.5
  • 5
    • 0037085683 scopus 로고    scopus 로고
    • ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators
    • Smriti, Krishnamurthy S, Dixit BL, Gupta CM, Milewski S, et al. (2002) ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators. Yeast 19: 303-318.
    • (2002) Yeast , vol.19 , pp. 303-318
    • Smriti, S.1    Krishnamurthy, S.2    Dixit, B.L.3    Gupta, C.M.4    Milewski, S.5
  • 7
    • 53849119555 scopus 로고    scopus 로고
    • Ins and outs of major facilitator superfamily antiporters
    • Law CJ, Maloney PC, Wang DN (2008) Ins and outs of major facilitator superfamily antiporters. Annu Rev Microbiol 62: 289-305.
    • (2008) Annu Rev Microbiol , vol.62 , pp. 289-305
    • Law, C.J.1    Maloney, P.C.2    Wang, D.N.3
  • 8
    • 74549157702 scopus 로고    scopus 로고
    • Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach
    • Kapoor K, Rehan M, Kaushiki A, Pasrija R, Lynn AM, et al. (2009) Rational mutational analysis of a multidrug MFS transporter CaMdr1p of Candida albicans by employing a membrane environment based computational approach. PLoS Comput Biol 5: e1000624.
    • (2009) PLoS Comput Biol , vol.e1000624 , pp. 5
    • Kapoor, K.1    Rehan, M.2    Kaushiki, A.3    Pasrija, R.4    Lynn, A.M.5
  • 9
    • 0036681416 scopus 로고    scopus 로고
    • Scoring residue conservation
    • Valdar WS (2002) Scoring residue conservation. Proteins 48: 227-241.
    • (2002) Proteins , vol.48 , pp. 227-241
    • Valdar, W.S.1
  • 10
    • 0018544480 scopus 로고
    • The neutral theory of molecular evolution
    • Kimura M (1979) The neutral theory of molecular evolution. Sci Am 241: 98-100, 102, 108.
    • (1979) Sci Am 241 , vol.102 , Issue.108 , pp. 98-100
    • Kimura, M.1
  • 11
    • 84856043672 scopus 로고
    • The mathematical theory of communication
    • & 623-656, July & October
    • Shannon CE (1948) The mathematical theory of communication. Bell System Technical Journal 27: 379-423 & 623-656, July & October.
    • (1948) Bell System Technical Journal , vol.27 , pp. 379-423
    • Shannon, C.E.1
  • 12
    • 0026030641 scopus 로고
    • Database of homology-derived protein structures and the structural meaning of sequence alignment
    • Sander C, Schneider R (1991) Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins 9: 56-68.
    • (1991) Proteins , vol.9 , pp. 56-68
    • Sander, C.1    Schneider, R.2
  • 15
    • 0037447059 scopus 로고    scopus 로고
    • Amino acids determining enzymesubstrate specificity in prokaryotic and eukaryotic protein kinases
    • Li L, Shakhnovich EI, Mirny LA (2003) Amino acids determining enzymesubstrate specificity in prokaryotic and eukaryotic protein kinases. Proc Natl Acad Sci U S A 100: 4463-4468.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4463-4468
    • Li, L.1    Shakhnovich, E.I.2    Mirny, L.A.3
  • 16
    • 0034644783 scopus 로고    scopus 로고
    • Analysis and prediction of functional subtypes from protein sequence alignments
    • Hannenhalli SS, Russell RB (2000) Analysis and prediction of functional subtypes from protein sequence alignments. J Mol Biol 303: 61-76.
    • (2000) J Mol Biol , vol.303 , pp. 61-76
    • Hannenhalli, S.S.1    Russell, R.B.2
  • 17
    • 69249213406 scopus 로고    scopus 로고
    • Identification of Nile red as a fluorescent substrate of the Candida albicans ATPbinding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p
    • Ivnitski-Steele I, Holmes AR, Lamping E, Monk BC, Cannon RD, et al. (2009) Identification of Nile red as a fluorescent substrate of the Candida albicans ATPbinding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p. Anal Biochem 394: 87-91.
    • (2009) Anal Biochem , vol.394 , pp. 87-91
    • Ivnitski-Steele, I.1    Holmes, A.R.2    Lamping, E.3    Monk, B.C.4    Cannon, R.D.5
  • 18
    • 34748840163 scopus 로고    scopus 로고
    • Functional specificity lies within the properties and evolutionary changes of amino acids 2
    • Chakrabarti S, Bryant SH, Panchenko AR (2007) Functional specificity lies within the properties and evolutionary changes of amino acids 2. J Mol Biol 373: 801-810.
    • (2007) J Mol Biol , vol.373 , pp. 801-810
    • Chakrabarti, S.1    Bryant, S.H.2    Panchenko, A.R.3
  • 19
    • 33746915689 scopus 로고    scopus 로고
    • Mutational and bioinformatics analysis of proline- and glycine-rich motifs in vesicular acetylcholine transporter
    • Chandrasekaran A, Ojeda AM, Kolmakova NG, Parsons SM (2006) Mutational and bioinformatics analysis of proline- and glycine-rich motifs in vesicular acetylcholine transporter. J Neurochem 98: 1551-1559.
    • (2006) J Neurochem , vol.98 , pp. 1551-1559
    • Chandrasekaran, A.1    Ojeda, A.M.2    Kolmakova, N.G.3    Parsons, S.M.4
  • 20
    • 0034050363 scopus 로고    scopus 로고
    • The TetA(K) tetracycline/H(+) antiporter from Staphylococcus aureus: Mutagenesis and functional analysis of motif C
    • Ginn SL, Brown MH, Skurray RA (2000) The TetA(K) tetracycline/H(+) antiporter from Staphylococcus aureus: mutagenesis and functional analysis of motif C. J Bacteriol 182: 1492-1498.
    • (2000) J Bacteriol , vol.182 , pp. 1492-1498
    • Ginn, S.L.1    Brown, M.H.2    Skurray, R.A.3
  • 21
    • 73549113828 scopus 로고    scopus 로고
    • Integration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transporters
    • Jeon J, Yang JS, Kim S (2009) Integration of evolutionary features for the identification of functionally important residues in major facilitator superfamily transporters. PLoS Comput Biol 5: e1000522.
    • (2009) PLoS Comput Biol , vol.e1000522 , pp. 5
    • Jeon, J.1    Yang, J.S.2    Kim, S.3
  • 22
    • 0035185602 scopus 로고    scopus 로고
    • Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters
    • Nakamura K, Niimi M, Niimi K, Holmes AR, Yates JE, et al. (2001) Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters. Antimicrob Agents Chemother 45: 3366-3374.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 3366-3374
    • Nakamura, K.1    Niimi, M.2    Niimi, K.3    Holmes, A.R.4    Yates, J.E.5
  • 23
    • 0032524635 scopus 로고    scopus 로고
    • ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p
    • Decottignies A, Grant AM, Nichols JW, De Wet H, McIntosh DB, et al. (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273: 12612-12622.
    • (1998) J Biol Chem , vol.273 , pp. 12612-12622
    • Decottignies, A.1    Grant, A.M.2    Nichols, J.W.3    de Wet, H.4    McIntosh, D.B.5
  • 25
    • 39149144057 scopus 로고    scopus 로고
    • PRALINETM: A strategy for improved multiple alignment of transmembrane proteins
    • Pirovano W, Feenstra KA, Heringa J (2008) PRALINETM: a strategy for improved multiple alignment of transmembrane proteins. Bioinformatics 24: 492-497.
    • (2008) Bioinformatics , vol.24 , pp. 492-497
    • Pirovano, W.1    Feenstra, K.A.2    Heringa, J.3
  • 26
    • 0035910270 scopus 로고    scopus 로고
    • Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes
    • Krogh A, Larsson B, von HG, Sonnhammer EL (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305: 567-580.
    • (2001) J Mol Biol , vol.305 , pp. 567-580
    • Krogh, A.1    Larsson, B.2    Von, H.G.3    Sonnhammer, E.L.4
  • 27
    • 3042666256 scopus 로고    scopus 로고
    • MUSCLE: Multiple sequence alignment with high accuracy and high throughput
    • Edgar RC (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res 32: 1792-1797.
    • (2004) Nucleic Acids Res , vol.32 , pp. 1792-1797
    • Edgar, R.C.1
  • 28
    • 0027764344 scopus 로고
    • Protein sequence alignments: A strategy for the hierarchical analysis of residue conservation
    • Livingstone CD, Barton GJ (1993) Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation. Comput Appl Biosci 9: 745-756.
    • (1993) Comput Appl Biosci , vol.9 , pp. 745-756
    • Livingstone, C.D.1    Barton, G.J.2
  • 29
    • 34247182735 scopus 로고    scopus 로고
    • HMM-ModE-improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying emission probabilities with negative training sequences
    • Srivastava PK, Desai DK, Nandi S, Lynn AM (2007) HMM-ModE-improved classification using profile hidden Markov models by optimising the discrimination threshold and modifying emission probabilities with negative training sequences. BMC Bioinformatics 8: 104.
    • (2007) BMC Bioinformatics , vol.8 , pp. 104
    • Srivastava, P.K.1    Desai, D.K.2    Nandi, S.3    Lynn, A.M.4
  • 30
    • 33947672774 scopus 로고    scopus 로고
    • Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: Identification of amino acid residues critical for drug/H+ transport
    • Pasrija R, Banerjee D, Prasad R (2007) Structure and function analysis of CaMdr1p, a major facilitator superfamily antifungal efflux transporter protein of Candida albicans: identification of amino acid residues critical for drug/H+ transport. Eukaryot Cell 6: 443-453.
    • (2007) Eukaryot Cell , vol.6 , pp. 443-453
    • Pasrija, R.1    Banerjee, D.2    Prasad, R.3
  • 31
    • 0027412196 scopus 로고
    • ALSCRIPT: A tool to format multiple sequence alignments
    • Barton GJ (1993) ALSCRIPT: a tool to format multiple sequence alignments. Protein Eng 6: 37-40.
    • (1993) Protein Eng , vol.6 , pp. 37-40
    • Barton, G.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.