Employing information theoretic measures and mutagenesis to identify residues critical for drug-proton antiport function in mdr1p of Candida albicans

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Kapoor, Khyati ^a   Rehan, Mohd ^a   Lynn, Andrew M ^a   Prasad, Rajendra ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ALANINE; ANISOMYCIN; CERULENIN; CYCLOHEXIMIDE; FLUCONAZOLE; LEUCINE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 1; DRUG; GLYCOPROTEIN P; PROTON;

AMINO ACID SUBSTITUTION; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; ENZYME SPECIFICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PREDICTION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

CANDIDA ALBICANS;

AMINO ACID SEQUENCE; BIOLOGICAL TRANSPORT; CANDIDA ALBICANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS; PROTONS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 77956223495     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011041     Document Type: Article

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