Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26315-26325

  Kashiwayama, Yoshinori ^a   Tomohiro, Takenori ^a   Narita, Kotomi ^a   Suzumura, Miyuki ^a   Glumoff, Tuomo ^b   Hiltunen, J Kalervo ^b   Van Veldhoven, Paul P ^c   Hatanaka, Yasumaru ^a   Imanaka, Tsuneo ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATALYTIC CENTER; FATTY ACID TRANSPORT; HYDROPHOBIC CAVITIES; MASS SPECTROMETRIC ANALYSIS; METABOLIC PATHWAYS; MOLECULAR MECHANISM; PALMITIC ACID; PHOTOAFFINITY LABELING; PHOTOAFFINITY LIGANDS; RAT LIVERS; SUBSTRATE BINDING; SUBSTRATE-BINDING SITES;

ACIDS; BEARINGS (STRUCTURAL); BINDING ENERGY; BIOCHEMISTRY; CATALYSTS; CRYSTAL STRUCTURE; CYTOLOGY; ENZYMES; FATTY ACIDS; HYDROPHOBICITY; LIGANDS; MASS SPECTROMETERS; OXIDATION; SPECTROMETRY; SUBSTRATES;

BINDING SITES;

3 [2 [2 [2 (2 TERT BUTOXYLCARBONYLAMINOETHOXY)ETHOXY]ETHOXY] 4 [3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL]PHENYL]ALANINE TERT BUTYL ESTER; ARGININE; LIGAND; MULTIFUNCTIONAL ENZYME TYPE 2; N (DIPHENYLMETHYLENE) 3 [2 [2 [2 (TERT BUTOXYLCARBONYLAMINOETHOXY)ETHOXY]ETHOXY] 4 [3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL]PHENYL]ALANINE TERT BUTYL ESTER; N PALMITOYL 3 [2 [2 [2 (2 AMINOETHOXY)ETHOXY]ETHOXY] 4 [3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL]]PHENYLALANINE; N PALMITOYL 3 [2 [2 [2 (2 BIOTINYLAMINOETHOXY)ETHOXY]ETHOXY] 4 [3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL]]PHENYLALANINE; N PALMITOYL 3 [2 [2 [2 (2 TERT BUTOXYLCARBONYLAMINOETHOXY)ETHOXY]ETHOXY] 4 [3 (TRIFLUOROMETHYL) 3H DIAZIRIN 3 YL]PHENYL]ALANINE TERT BUTYL ESTER; PALMITIC ACID DERIVATIVE; PALMITOYL COENZYME A; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FATTY ACID OXIDATION; FRAGMENTATION REACTION; HYDROPHOBICITY; LIVER; MALE; MASS SPECTROMETRY; MUTATION; NONHUMAN; PEROXISOME; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; RESIDUE ANALYSIS;

17-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; BINDING SITES; DIAZOMETHANE; ENOYL-COA HYDRATASE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIVER; MOLECULAR PROBE TECHNIQUES; MULTIENZYME COMPLEXES; MUTATION, MISSENSE; OXIDATION-REDUCTION; PALMITIC ACID; PEROXISOMES; PHOTOAFFINITY LABELS; RATS;

RATTUS;

EID: 77956197167     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.104547     Document Type: Article

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