The adaptor protein Sh2d3c is critical for marginal zone B cell development and function

Journal of Immunology

Volumn 185, Issue 1, 2010, Pages 327-334

  Al Shami, Amin ^a   Wilkins, Carrie ^a   Crisostomo, Jeannette ^a   Seshasayee, Dhaya ^b   Martin, Flavius ^b   Xu, Nianhua ^a   Suwanichkul, Adisak ^a   Anderson, Stephen J ^a   Oravecz, Tamas ^a  

^a LEXICON PHARMACEUTICALS INC   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; FOCAL ADHESION KINASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTEGRIN; INTERLEUKIN 10; INTERLEUKIN 6; POLYSACCHARIDE; PROTEIN SH2D3C; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; SH2D3C PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; THYMUS INDEPENDENT ANTIGEN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL COUNT; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EX VIVO STUDY; FEMALE; GENE; HEMATOPOIETIC CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SH2D3C GENE; SIGNAL TRANSDUCTION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; THYMUS; WILD TYPE; ANIMAL; CALCIUM SIGNALING; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTOPENIA; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS; SPLEEN; T LYMPHOCYTE SUBPOPULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, T-INDEPENDENT; B-LYMPHOCYTE SUBSETS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CHEMOTAXIS, LEUKOCYTE; FEMALE; LYMPHOPENIA; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTE SUBSETS; THYMUS GLAND;

EID: 77956194979     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000096     Document Type: Article

References (43)

1. Dodelet, V. C., C. Pazzagli, A. H. Zisch, C. A. Hauser, and E. B. Pasquale. 1999. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J. Biol. Chem. 274: 31941-31946.
2. Sakakibara, A., and S. Hattori. 2000. Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J. Biol. Chem. 275: 6404-6410.
3. Lu, Y., J. Brush, and T. A. Stewart. 1999. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J. Biol. Chem. 274: 10047-10052.
4. van Agthoven, T., T. L. van Agthoven, A. Dekker, P. J. van der Spek, L. Vreede, and L. C. Dorssers. 1998. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J. 17: 2799-2808.
5. Dail, M., M. S. Kalo, J. A. Seddon, J. F. Côté, K. Vuori, and E. B. Pasquale. 2004. SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J. Biol. Chem. 279: 41892-41902.
6. Sakakibara, A., S. Hattori, S. Nakamura, and T. Katagiri. 2003. A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells. J. Biol. Chem. 278: 6012-6017.
7. Derunes, C., R. Burgess, E. Iraheta, R. Kellerer, K. Becherer, C. R. Gessner, S. Li, K. Hewitt, K. Vuori, E. B. Pasquale, et al. 2006. Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex. FEBS Lett. 580: 175-178. (Pubitemid 43005332)
8. Ishino, M., T. Ohba, H. Sasaki, and T. Sasaki. 1995. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn. Oncogene 11: 2331-2338. (Pubitemid 26008410)
9. Sakai, R., A. Iwamatsu, N. Hirano, S. Ogawa, T. Tanaka, H. Mano, Y. Yazaki, and H. Hirai. 1994. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 13: 3748-3756.
10. Sakakibara, A., Y. Ohba, K. Kurokawa, M. Matsuda, and S. Hattori. 2002. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway- mediated Rap1 activation. J. Cell Sci. 115: 4915-4924. (Pubitemid 36054643)
11. Riggins, R. B., L. A. Quilliam, and A. H. Bouton. 2003. Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. J. Biol. Chem. 278: 28264-28273.
12. Schwarz, B. A., and A. Bhandoola. 2006. Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis. Immunol. Rev. 209: 47-57.
13. Hao, Z., and K. Rajewsky. 2001. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J. Exp. Med. 194: 1151-1164.
14. Pillai, S., A. Cariappa, and S. T. Moran. 2005. Marginal zone B cells. Annu. Rev. Immunol. 23: 161-196.
15. Cyster, J. G. 2000. B cells on the front line. Nat. Immunol. 1: 9-10.
16. Lopes-Carvalho, T., J. Foote, and J. F. Kearney. 2005. Marginal zone B cells in lymphocyte activation and regulation. Curr. Opin. Immunol. 17: 244-250.
17. Zandvoort, A., and W. Timens. 2002. The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens. Clin. Exp. Immunol. 130: 4-11.
18. Martin, F., and J. F. Kearney. 2002. Marginal-zone B cells. Nat. Rev. Immunol. 2: 323-335.
19. Martin, F., and J. F. Kearney. 2001. B1 cells: similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13: 195-201.
20. Martin, F., A. M. Oliver, and J. F. Kearney. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14: 617-629.
21. Wattler, S., M. Kelly, and M. Nehls. 1999. Construction of gene targeting vectors from lambda KOS genomic libraries. BioTechniques 26: 1150-1156, 1158, 1160.
22. Guinamard, R., M. Okigaki, J. Schlessinger, and J. V. Ravetch. 2000. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat. Immunol. 1: 31-36.
23. Anderson, S. J., J. P. Lauritsen, M. G. Hartman, A. M. Foushee, J. M. Lefebvre, S. A. Shinton, B. Gerhardt, R. R. Hardy, T. Oravecz, and D. L. Wiest. 2007. Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. Immunity 26: 759-772.
24. + T cell development. J. Exp. Med. 200: 159-168.
25. Beltrandelrio, H., F. Kern, T. Lanthorn, T. Oravecz, J. Piggott, D. Powell, R. Ramirez-Solis, A. T. Sands, and B. Zambrowicz. 2003. Saturation screening of the druggable mammalian genome. In Model Organisms in Drug Discovery. P. M. Carroll, and K. Fitzgerald, eds. John Wiley & Sons, Chichester, United Kingdom, pp. 251-278.
26. Kraal, G., and M. Janse. 1986. Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody. Immunology 58: 665-669. (Pubitemid 16068145)
27. Karlsson, M. C., R. Guinamard, S. Bolland, M. Sankala, R. M. Steinman, and J. V. Ravetch. 2003. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J. Exp. Med. 198: 333-340.
28. high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J. Immunol. 162: 7198-7207.
29. Hargreaves, D. C., P. L. Hyman, T. T. Lu, V. N. Ngo, A. Bidgol, G. Suzuki, Y. R. Zou, D. R. Littman, and J. G. Cyster. 2001. A coordinated change in chemokine responsiveness guides plasma cell movements. J. Exp. Med. 194: 45-56.
30. Bleul, C. C., R. C. Fuhlbrigge, J. M. Casasnovas, A. Aiuti, and T. A. Springer. 1996. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 184: 1101-1109.
31. Ansel, K. M., V. N. Ngo, P. L. Hyman, S. A. Luther, R. Förster, J. D. Sedgwick, J. L. Browning, M. Lipp, and J. G. Cyster. 2000. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406: 309-314.
32. Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23: 127-159.
33. Dikic, I., I. Dikic, and J. Schlessinger. 1998. Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J. Biol. Chem. 273: 14301-14308.
34. Allman, D., B. Srivastava, and R. C. Lindsley. 2004. Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunol. Rev. 197: 147-160.
35. Sun, T., M. R. Clark, and U. Storb. 2002. A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity 16: 245-255.
36. Cariappa, A., M. Tang, C. Parng, E. Nebelitskiy, M. Carroll, K. Georgopoulos, and S. Pillai. 2001. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity 14: 603-615. (Pubitemid 32520871)
37. Makowska, A., N. N. Faizunnessa, P. Anderson, T. Midtvedt, and S. Cardell. 1999. CD1high B cells: a population of mixed origin. Eur. J. Immunol. 29: 3285-3294.
38. Martin, F., and J. F. Kearney. 2000. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 12: 39-49.
39. Ferguson, A. R., M. E. Youd, and R. B. Corley. 2004. Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells. Int. Immunol. 16: 1411-1422.
40. Seo, S., T. Asai, T. Saito, T. Suzuki, Y. Morishita, T. Nakamoto, M. Ichikawa, G. Yamamoto, M. Kawazu, T. Yamagata, et al. 2005. Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance. J. Immunol. 175: 3492-3501.
41. Kamiguchi, K., K. Tachibana, S. Iwata, Y. Ohashi, and C. Morimoto. 1999. Cas-L is required for beta 1 integrin-mediated costimulation in human T cells. J. Immunol. 163: 563-568. (Pubitemid 29328056)
42. Xiong, W. C., M. Macklem, and J. T. Parsons. 1998. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. J. Cell Sci. 111: 1981-1991.
43. + T lymphocytes. Eur. J. Immunol. 28: 3867-3877.