The tubular epithelium in the initiation and course of intratubular nephrocalcinosis

Urological Research

Volumn 38, Issue 4, 2010, Pages 249-256

  Vervaet, Benjamin A ^a   Verhulst, Anja ^a   De Broe, Marc E ^a   D'Haese, Patrick C ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Crystal clearance; Dedifferentiation; Nephrocalcinosis; Tubular epithelium

Indexed keywords

ANGIOTENSIN II; ATORVASTATIN; CALCIUM OXALATE; CALCIUM PHOSPHATE;

CELL ADHESION; CELL DEDIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; CONFERENCE PAPER; CRYSTAL DEPOSITION; CRYSTAL RETENTION; CRYSTAL STRUCTURE; CRYSTALLIZATION; HISTOPATHOLOGY; IN VIVO STUDY; KIDNEY CALCIFICATION; KIDNEY FUNCTION; KIDNEY TUBULE CELL; KIDNEY TUBULE EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; TEA;

EPITHELIUM; HUMANS; KIDNEY TUBULES; NEPHROCALCINOSIS; PHENOTYPE;

EID: 77956191682     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00240-010-0290-5     Document Type: Conference Paper

References (102)

1. W Gwinner S Suppa M Mengel L Hoy HH Kreipe H Haller A Schwarz 2005 Early calcification of renal allografts detected by protocol biopsies: causes and clinical implications Am J Transplant 8 1934 1941 10.1111/j.1600-6143.2005. 00938.x
2. ME Katz MG Karlowicz RD Adelman AL Werner MJ Solhaug 1994 Nephrocalcinosis in very low birth weight neonates: sonographic patterns, histologic characteristics, and clinical risk factors J Ultrasound Med 10 777 782
3. DR Mole CR Tomson N Mortensen CG Winearls 2001 Renal complications of jejuno-ileal bypass for obesity QJM 2 69 77 10.1093/qjmed/94.2.69
4. AP Evan JE Lingeman FL Coe Y Shao JH Parks SB Bledsoe CL Phillips S Bonsib EM Worcester AJ Sommer SC Kim WW Tinmouth M Grynpas 2005 Crystal-associated nephropathy in patients with brushite nephrolithiasis Kidney Int 2 576 591 10.1111/j.1523-1755.2005.67114.x
5. AE Evan JE Lingeman FL Coe NL Miller SB Bledsoe AJ Sommer JC Williams Y Shao EM Worcester 2008 Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones Kidney Int 2 223 229 10.1038/ki.2008.161
6. DJ Kok 1996 Crystallization and stone formation inside the nephron Scanning Microsc 2 471 484
7. JR Asplin JH Parks FL Coe 1997 Dependence of upper limit of metastability on supersaturation in nephrolithiasis Kidney Int 6 1602 1608 10.1038/ki.1997.491
8. DJ Kok 1997 Intratubular crystallization events World J Urol 4 219 228 10.1007/BF01367659
9. HG Tiselius 1997 Estimated levels of supersaturation with calcium phosphate and calcium oxalate in the distal tubule Urol Res 2 153 159 10.1007/BF01037933
10. JH Parks FL Coe AP Evan EM Worcester 2009 Urine pH in renal calcium stone formers who do and do not increase stone phosphate content with time Nephrol Dial Transplant 1 130 136
11. Evan AP (2009) Physiopathology and etiology of stone formation in the kidney and the urinary tract. Pediatr Nephrol
12. Tiselius HG, Hojgaard I (1999) Some aspects of the intratubular precipitation of calcium salts. J Am Soc Nephrol:S371-S375
13. Coe FL, Parks JH, Evan A, Worcester EM (2007) Pathogenesis and treatment of nephrolithiasis. In: Alpern RJ, Hebert SC (eds) Seldin and Giebisch's the kidney, 4th edn. Academic Press, Burlington, pp 197-1945
14. KY Renkema A Velic HB Dijkman S Verkaart AW van der Kemp M Nowik K Timmermans A Doucet CA Wagner RJ Bindels JG Hoenderop 2009 The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis J Am Soc Nephrol 8 1705 1713 10.1681/ASN.2008111195
15. JA Sayer G Carr NL Simmons 2004 Nephrocalcinosis: molecular insights into calcium precipitation within the kidney Clin Sci (Lond) 6 549 561 10.1042/CS20040048
16. Unuma K, Tojo A, Harada K, Saka K, Nakajima M, Ishii T, Fujita T, Yoshida K (2009) Autopsy report on pseudo-Bartter syndrome with renal calcification induced by diuretics and diet pills. BMJ Case Rep. doi: 10.1136/bcr.12.2008.1380
17. O Devuyst Y Pirson 2007 Genetics of hypercalciuric stone forming diseases Kidney Int 9 1065 1072 10.1038/sj.ki.5002441
18. AP Evan J Lingeman F Coe Y Shao N Miller B Matlaga C Phillips A Sommer E Worcester 2007 Renal histopathology of stone-forming patients with distal renal tubular acidosis Kidney Int 8 795 801 10.1038/sj.ki.5002113
19. Wagner CA, Geibel JP (2002) Acid-base transport in the collecting duct. J Nephrol:S112-S127
20. CT Lee HC Chen LW Lai KC Yong YH Lien 2007 Effects of furosemide on renal calcium handling Am J Physiol Renal Physiol 4 F1231 F1237 10.1152/ajprenal. 00038.2007
21. AE Bobrowski CB Langman 2008 The primary hyperoxalurias Semin Nephrol 2 152 162 10.1016/j.semnephrol.2008.01.008
22. WG Robertson M Peacock BE Nordin 1969 Calcium crystalluria in recurrent renal-stone formers Lancet 294 7610 21 24 10.1016/S0140-6736(69)92598-7
23. JS Elliot IN Rabinowitz 1980 Calcium oxalate crystalluria: crystal size in urine J Urol 3 324 327
24. B Finlayson F Reid 1978 The expectation of free and fixed particles in urinary stone disease Invest Urol 6 442 448
25. GS Markowitz SH Nasr P Klein H Anderson JI Stack L Alterman B Price J Radhakrishnan VD D'Agati 2004 Renal failure due to acute nephrocalcinosis following oral sodium phosphate bowel cleansing Hum Pathol 6 675 684 10.1016/j.humpath.2003.12.005
26. A Verhulst M Asselman S De Naeyer BA Vervaet M Mengel W Gwinner PC D'Haese CF Verkoelen ME De Broe 2005 Preconditioning of the distal tubular epithelium of the human kidney precedes nephrocalcinosis Kidney Int 4 1643 1647 10.1111/j.1523-1755.2005.00584.x
27. SR Khan PN Shevock RL Hackett 1992 Acute hyperoxaluria, renal injury and calcium oxalate urolithiasis J Urol 1 226 230
28. BJ Nankivell RJ Borrows CL Fung PJ O'Connell RD Allen JR Chapman 2003 The natural history of chronic allograft nephropathy N Engl J Med 24 2326 2333 10.1056/NEJMoa020009
29. EA Schell-Feith JE Kist-Van Holthe N Conneman PH van Zwieten HC Holscher HM Zonderland R Brand BJ van der Heijden 2000 Etiology of nephrocalcinosis in preterm neonates: association of nutritional intake and urinary parameters Kidney Int 5 2102 2110 10.1111/j.1523-1755.2000.00383.x
30. A Schwarz M Mengel W Gwinner J Radermacher M Hiss H Kreipe H Haller 2005 Risk factors for chronic allograft nephropathy after renal transplantation: a protocol biopsy study Kidney Int 1 341 348 10.1111/j.1523-1755.2005.00087.x
31. DJ Kok SR Khan 1994 Calcium oxalate nephrolithiasis, a free or fixed particle disease Kidney Int 3 847 854 10.1038/ki.1994.341
32. WG Robertson 2004 Kidney models of calcium oxalate stone formation Nephron Physiol 2 21 30 10.1159/000080260
33. C.B. Huggins 1933 Bone and calculi in the collecting tubules of the kidney Arch Surg 1 203 215
34. De Albuquerque PF, De Paola D (1959) Experiments in urolithiasis: I. Histochemical studies. J Urol:345-350
35. RC Haggitt JA Pitcock 1971 Renal medullary calcifications: a light and electron microscopic study J Urol 3 342 347
36. JS King Jr 1967 Etiologic factors involved in urolithiasis: a review of recent research J Urol 4 583 591
37. J Oliver M MacDowell R Whang LG Welt 1966 The renal lesions of electrolyte imbalance. IV. The intranephronic calculosis of experimental magnesium depletion J Exp Med 2 263 278 10.1084/jem.124.2.263
38. K Morgenroth Jr R Backmann R Blaschke 1968 On the forms of calcium oxalate deposits in the human kidney in oxalosis Beitr Pathol Anat 4 454 463
39. SR Khan B Finlayson RL Hackett 1979 Histologic study of the early events in oxalate induced intranephronic calculosis Invest Urol 3 199 202
40. MJ Dykstra RL Hackett 1979 Ultrastructural events in early calcium oxalate crystal formation in rats Kidney Int 6 640 650 10.1038/ki.1979.84
41. K Sarica A Erbagci F Yagci K Bakir S Erturhan R Ucak 2004 Limitation of apoptotic changes in renal tubular cell injury induced by hyperoxaluria Urol Res 4 271 277 10.1007/s00240-003-0393-3
42. M Asselman A Verhulst ME De Broe CF Verkoelen 2003 Calcium oxalate crystal adherence to hyaluronan-, osteopontin-, and CD44-expressing injured/regenerating tubular epithelial cells in rat kidneys J Am Soc Nephrol 12 3155 3166 10.1097/01.ASN.0000099380.18995.F7
43. MW Bigelow JH Wiessner JG Kleinman NS Mandel 1998 Calcium oxalate crystal attachment to cultured kidney epithelial cell lines J Urol 4 1528 1532
44. Riese RJ, Mandel NS, Wiessner JH, Mandel GS, Becker CG, Kleinman JG (1992) Cell polarity and calcium oxalate crystal adherence to cultured collecting duct cells. Am J Physiol (2 Pt 2):F177-F184
45. Verkoelen CF, van der Boom BG, Houtsmuller AB, Schroder FH, Romijn JC (1998) Increased calcium oxalate monohydrate crystal binding to injured renal tubular epithelial cells in culture. Am J Physiol (5 Pt 2):F958-F965
46. A Verhulst M Asselman VP Persy MS Schepers MF Helbert CF Verkoelen ME De Broe 2003 Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium J Am Soc Nephrol 1 107 115 10.1097/01.ASN.0000038686.17715.42
47. Kleinman JG, Sorokina EA, Wesson JA (2010) Induction of apoptosis with cisplatin enhances calcium oxalate crystal adherence to inner medullary collecting duct cells. Urol Res
48. CF Verkoelen BG van der Boom DJ Kok AB Houtsmuller P Visser FH Schroder JC Romijn 1999 Cell type-specific acquired protection from crystal adherence by renal tubule cells in culture Kidney Int 4 1426 1433 10.1046/j.1523-1755.1999. 00383.x
49. CF Verkoelen BG van der Boom JC Romijn 2000 Identification of hyaluronan as a crystal-binding molecule at the surface of migrating and proliferating MDCK cells Kidney Int 3 1045 1054 10.1046/j.1523-1755.2000.00262.x
50. M Asselman A Verhulst ES Van Ballegooijen CH Bangma CF Verkoelen ME De Broe 2005 Hyaluronan is apically secreted and expressed by proliferating or regenerating renal tubular cells Kidney Int 1 71 83 10.1111/j.1523-1755.2005. 00382.x
51. EA Sorokina JA Wesson JG Kleinman 2004 An acidic peptide sequence of nucleolin-related protein can mediate the attachment of calcium oxalate to renal tubule cells J Am Soc Nephrol 8 2057 2065 10.1097/01.ASN.0000133024.83256.C8
52. Bigelow MW, Wiessner JH, Kleinman JG, Mandel NS (1997) Surface exposure of phosphatidylserine increases calcium oxalate crystal attachment to IMCD cells. Am J Physiol (1 Pt 2):F55-F62
53. Lieske JC, Leonard R, Swift H, Toback FG (1996) Adhesion of calcium oxalate monohydrate crystals to anionic sites on the surface of renal epithelial cells. Am J Physiol (1 Pt 2):F192-F199
54. Lieske JC, Norris R, Toback FG (1997) Adhesion of hydroxyapatite crystals to anionic sites on the surface of renal epithelial cells. Am J Physiol (2 Pt 2):F224-F233
55. JH Wiessner AT Hasegawa LY Hung GS Mandel NS Mandel 2001 Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells Kidney Int 2 637 644 10.1046/j.1523-1755.2001.059002637.x
56. K Kohri M Kodama Y Ishikawa Y Katayama H Matsuda M Imanishi M Takada Y Katoh K Kataoka T Akiyama 1991 Immunofluorescent study on the interaction between collagen and calcium oxalate crystals in the renal tubules Eur Urol 3 249 252
57. T Yamate K Kohri T Umekawa N Amasaki N Amasaki Y Isikawa M Iguchi T Kurita 1996 The effect of osteopontin on the adhesion of calcium oxalate crystals to Madin-Darby canine kidney cells Eur Urol 3 388 393
58. T Yamate K Kohri T Umekawa E Konya Y Ishikawa M Iguchi T Kurita 1999 Interaction between osteopontin on Madin-Darby canine kidney cell membrane and calcium oxalate crystal Urol Int 2 81 86 10.1159/000030363
59. T Yamate K Kohri T Umekawa M Iguchi T Kurita 1998 Osteopontin antisense oligonucleotide inhibits adhesion of calcium oxalate crystals in Madin-Darby canine kidney cell J Urol 4 1506 1512
60. V Kumar G Farell S Deganello JC Lieske 2003 Annexin II is present on renal epithelial cells and binds calcium oxalate monohydrate crystals J Am Soc Nephrol 2 289 297 10.1097/01.ASN.0000046030.24938.0A
61. G Carr NL Simmons JA Sayer 2006 Disruption of clc-5 leads to a redistribution of annexin A2 and promotes calcium crystal agglomeration in collecting duct epithelial cells Cell Mol Life Sci 3 367 377 10.1007/s00018-005-5510-8
62. EA Sorokina JG Kleinman 1999 Cloning and preliminary characterization of a calcium-binding protein closely related to nucleolin on the apical surface of inner medullary collecting duct cells J Biol Chem 39 27491 27496 10.1074/jbc.274.39.27491
63. Lieske JC, Leonard R, Toback FG (1995) Adhesion of calcium oxalate monohydrate crystals to renal epithelial cells is inhibited by specific anions. Am J Physiol (4 Pt 2):F604-F612
64. K Aihara KJ Byer SR Khan 2003 Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species Kidney Int 4 1283 1291 10.1046/j.1523-1755.2003.00226.x
65. S Thamilselvan SR Khan M Menon 2003 Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants Urol Res 1 3 9
66. T Umekawa N Chegini SR Khan 2002 Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells Kidney Int 1 105 112 10.1046/j.1523-1755.2002.00106.x
67. T Umekawa N Chegini SR Khan 2003 Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals Nephrol Dial Transplant 4 664 669 10.1093/ndt/gfg140
68. Lieske JC, Walsh-Reitz MM, Toback FG (1992) Calcium oxalate monohydrate crystals are endocytosed by renal epithelial cells and induce proliferation. Am J Physiol (4 Pt 2):F622-F630
69. S Kumar D Sigmon T Miller B Carpenter S Khan R Malhotra C Scheid M Menon 1991 A new model of nephrolithiasis involving tubular dysfunction/injury J Urol 5 1384 1389
70. YQ Xue DL He XF Chen X Li J Zeng XY Wang 2009 Shock wave induced kidney injury promotes calcium oxalate deposition J Urol 2 762 765 10.1016/j.juro.2009. 03.080
71. SR Khan 2005 Hyperoxaluria-induced oxidative stress and antioxidants for renal protection Urol Res 5 349 357 10.1007/s00240-005-0492-4
72. Baud L, Ardaillou R (1986) Reactive oxygen species: production and role in the kidney. Am J Physiol (5 Pt 2):F765-F776
73. L Baud R Ardaillou 1993 Involvement of reactive oxygen species in kidney damage Br Med Bull 3 621 629
74. SP Andreoli 1991 Reactive oxygen molecules, oxidant injury and renal disease Pediatr Nephrol 6 733 742 10.1007/BF00857888
75. Abid MR, Razzaque MS, Taguchi T (2005) Oxidant stress in renal pathophysiology. Contrib Nephrol:135-153
76. HS Huang J Chen CF Chen MC Ma 2006 Vitamin E attenuates crystal formation in rat kidneys: roles of renal tubular cell death and crystallization inhibitors Kidney Int 4 699 710 10.1038/sj.ki.5001651
77. S Thamilselvan M Menon 2005 Vitamin E therapy prevents hyperoxaluria-induced calcium oxalate crystal deposition in the kidney by improving renal tissue antioxidant status BJU Int 1 117 126 10.1111/j.1464-410X. 2005.05579.x
78. S Wassmann U Laufs K Muller C Konkol K Ahlbory AT Baumer W Linz M Bohm G Nickenig 2002 Cellular antioxidant effects of atorvastatin in vitro and in vivo Arterioscler Thromb Vasc Biol 2 300 305 10.1161/hq0202.104081
79. Y Itoh T Yasui A Okada K Tozawa Y Hayashi K Kohri 2005 Preventive effects of green tea on renal stone formation and the role of oxidative stress in nephrolithiasis J Urol 1 271 275 10.1097/01.ju.0000141311.51003.87
80. Toblli JE, Ferder L, Stella I, De Cavanaugh EM, Angerosa M, Inserra F (2002) Effects of angiotensin II subtype 1 receptor blockade by losartan on tubulointerstitial lesions caused by hyperoxaluria. J Urol (4 Pt 1):1550-1555
81. JE Toblli L Ferder I Stella M Angerosa F Inserra 2001 Protective role of enalapril for chronic tubulointerstitial lesions of hyperoxaluria J Urol 1 275 280
82. B Antus MS Exton L Rosivall 2001 Angiotensin II: a regulator of inflammation during renal disease? Int J Immunopathol Pharmacol 1 25 30
83. CY Li YL Deng BH Sun 2009 Taurine protected kidney from oxidative injury through mitochondrial-linked pathway in a rat model of nephrolithiasis Urol Res 4 211 220 10.1007/s00240-009-0197-1
84. BA Vervaet PC D'Haese ME De Broe A Verhulst 2009 Crystalluric and tubular epithelial parameters during the onset of intratubular nephrocalcinosis: illustration of the 'fixed particle' theory in vivo Nephrol Dial Transplant 12 3659 3668 10.1093/ndt/gfp418
85. MS Schepers ES Van Ballegooijen CH Bangma CF Verkoelen 2005 Crystals cause acute necrotic cell death in renal proximal tubule cells, but not in collecting tubule cells Kidney Int 4 1543 1553 10.1111/j.1523-1755.2005.00566.x
86. C Escobar KJ Byer H Khaskheli SR Khan 2008 Apatite induced renal epithelial injury: insight into the pathogenesis of kidney stones J Urol 1 379 387 10.1016/j.juro.2008.02.041
87. T Umekawa M Iguchi H Uemura SR Khan 2006 Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts BJU Int 3 656 660 10.1111/j.1464-410X.2006.06334. x
88. T Saarela A Vaarala P Lanning M Koivisto 1999 Incidence, ultrasonic patterns and resolution of nephrocalcinosis in very low birthweight infants Acta Paediatr 6 655 660 10.1080/08035259950169332
89. A Auron US Alon 2005 Resolution of medullary nephrocalcinosis in children with metabolic bone disorders Pediatr Nephrol 8 1143 1145 10.1007/s00467-005- 1899-4
90. NB Dhar S Grundfest JS Jones SB Streem 2005 Jejunoileal bypass reversal: effect on renal function, metabolic parameters and stone formation J Urol 5 1844 1846 10.1097/01.ju.0000177079.56949.1a
91. WC De Bruijn ER Boeve PR van Run PP van Miert R de Water JC Romijn CF Verkoelen LC Cao FH Schroder 1995 Etiology of calcium oxalate nephrolithiasis in rats. I. Can this be a model for human stone formation? Scanning Microsc 1 103 114
92. BA Vervaet A Verhulst SE Dauwe ME De Broe PC D'Haese 2009 An active renal crystal clearance mechanism in rat and man Kidney Int 1 41 51 10.1038/ki.2008.450
93. JC Lieske R Norris H Swift FG Toback 1997 Adhesion, internalization and metabolism of calcium oxalate monohydrate crystals by renal epithelial cells Kidney Int 5 1291 1301 10.1038/ki.1997.454
94. JC Lieske H Swift T Martin B Patterson FG Toback 1994 Renal epithelial cells rapidly bind and internalize calcium oxalate monohydrate crystals Proc Natl Acad Sci USA 15 6987 6991 10.1073/pnas.91.15.6987
95. MS Schepers RA Duim M Asselman JC Romijn FH Schroder CF Verkoelen 2003 Internalization of calcium oxalate crystals by renal tubular cells: a nephron segment-specific process? Kidney Int 2 493 500 10.1046/j.1523-1755.2003.00107.x
96. PK Grover LA Thurgood DE Fleming W van Bronswijk T Wang RL Ryall 2008 Intracrystalline urinary proteins facilitate degradation and dissolution of calcium oxalate crystals in cultured renal cells Am J Physiol Renal Physiol 2 F355 F361
97. AP Evan FL Coe JE Lingeman Y Shao BR Matlaga SC Kim SB Bledsoe AJ Sommer M Grynpas CL Phillips EM Worcester 2006 Renal crystal deposits and histopathology in patients with cystine stones Kidney Int 12 2227 2235 10.1038/sj.ki.5000268
98. V Persy A Postnov E Neven G Dams M De Broe P D'Haese N De Clerck 2006 High-resolution X-ray microtomography is a sensitive method to detect vascular calcification in living rats with chronic renal failure Arterioscler Thromb Vasc Biol 9 2110 2116 10.1161/01.ATV.0000236200.02726.f7
99. CA Brown KS Jeong RH Poppenga B Puschner DM Miller AE Ellis KI Kang S Sum AM Cistola SA Brown 2007 Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007 J Vet Diagn Invest 5 525 531
100. R de Water C Noordermeer AB Houtsmuller AL Nigg T Stijnen FH Schroder DJ Kok 2000 Role of macrophages in nephrolithiasis in rats: an analysis of the renal interstitium Am J Kidney Dis 3 615 625
101. R de Water C Noordermeer TH van der Kwast H Nizze ER Boeve DJ Kok FH Schroder 1999 Calcium oxalate nephrolithiasis: effect of renal crystal deposition on the cellular composition of the renal interstitium Am J Kidney Dis 4 761 771
102. A Okada S Nomura Y Higashibata M Hirose B Gao M Yoshimura Y Itoh T Yasui K Tozawa K Kohri 2007 Successful formation of calcium oxalate crystal deposition in mouse kidney by intraabdominal glyoxylate injection Urol Res 2 89 99 10.1007/s00240-007-0082-8