Atorvastatin preconditioning attenuates the production of endothelin-1 and prevents experimental vasospasm in rats

Acta Neurochirurgica

Volumn 152, Issue 8, 2010, Pages 1399-1405

  Chang, Chih Zen ^a,b,c   Wu, Shu Chuan ^b   Lin, Chih Long ^a,b   Hwang, Shiuh Lin ^a,b   Howng, Shen Long ^a,b   Kwan, Aij Lie ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c KAOHSIUNG MUNICIPAL TA TUNG HOSPITAL   (Taiwan)

Author keywords

Atorvastatin; Endothelin 1; Nitric oxide synthase; Pleiotropic; Subarachnoid hemorrhage; Vasospasm

Indexed keywords

ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BASILAR ARTERY; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; ISCHEMIC PRECONDITIONING; MALE; MUSCLE NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; SHAM PROCEDURE; SMOOTH MUSCLE; SUBARACHNOID HEMORRHAGE; VASODILATATION; VASOSPASM;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; ISCHEMIC PRECONDITIONING; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SUBARACHNOID HEMORRHAGE; TREATMENT OUTCOME; VASODILATION; VASOSPASM, INTRACRANIAL;

EID: 77956190763     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-010-0652-3     Document Type: Article

References (42)

1. P Amarenco AM Tonkin 2004 Statins for stroke prevention: disappointment and hope Circulation 109 III44 III49 10.1161/01.CIR.0000131518.25959.8F 15198966
2. LM Blanco-Colio J Tunon JL Martin-Ventura J Egido 2003 Antiinflammatory and immunomodulatory effects of statins Kidney Int 63 12 23 10.1046/j.1523-1755. 2003.00744.x 1:CAS:528:DC%2BD3sXmtV2juw%3D%3D 12472764
3. J Bosel F Gandor C Harms M Synowitz U Harms PC Djoufack D Megow U Dirnagl H Hortnag KB Fink M Endres 2005 Neuroprotective effects of atorvastatin against glutamate-induced excito-toxicity in primary cortical neurons J Neurochem 92 1386 1398 10.1111/j.1471-4159.2004.02980.x 15748157
4. M Endres U Laufs Z Huang T Nakamura P Huang MA Moskowitz JK Liao 1998 Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase Proc Natl Acad Sci USA 95 8880 8885 10.1073/pnas.95.15.8880 1:CAS:528:DyaK1cXkvFalt70%3D 9671773
5. B Erdos JA Snipes CD Tulbert P Katakam AW Miller DW Busija 2006 Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production Am J Physiol Heart Circ Physiol 290 H1264 H1270 10.1152/ajpheart.00804.2005 1:CAS:528: DC%2BD28XjtFCgtbs%3D 16284235
6. F Gao E Gao TL Yue EH Ohlstein BL Lopez TA Christopher XL Ma 2002 Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation Circulation 105 1497 1502 10.1161/01.CIR.0000012529. 00367.0F 1:CAS:528:DC%2BD38XjsVyrtbc%3D 11914261
7. JP Grieve R Stacey E Moore ND Kitchen HR Jäger 1999 Artifact on MRA following aneurysm clipping: an in vitro study and prospective comparison with conventional angiography Neuroradiology 41 9 680 686 10.1007/s002340050824 1:STN:280:DyaK1MvlslSjuw%3D%3D 10525771
8. FM Ho WW Lin BC Chen CM Chao CR Yang LY Lin CC Lai SH Liu CS Liau 2006 High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway Cell Sign 18 391 399 10.1016/j.cellsig.2005.05.009 1:CAS:528:DC%2BD2MXht1GhsLzF
9. I Inoue MK Goto T Awata T Mastunaga S Kawai T Nakajima S Hokari T Komoda S Katayama 2000 Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of MRNA levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial cells Life Sci 67 863 876 10.1016/S0024-3205(00)00680-9 1:CAS:528:DC%2BD3cXltlWjtrc%3D 10946846
10. H Jeon J Ai M Sabri A Tariq X Shang G Chen RL Macdonald 2009 Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage BMC Neurosci 10 102 129 10.1186/1471-2202-10-103
11. AY Jeng P Mulder AL Kwan B Battistini 2002 Nonpeptidic endothelin-converting enzyme inhibitors and their potential therapeutic applications Can J Physiol Pharmacol 80 5 440 449 10.1139/y02-025 1:CAS:528:DC%2BD38XktFWitbs%3D 12056551
12. FB Jolicoeur DB Rondeau E Hamel RF Butterworth A Barbeau 1979 Measurement of ataxia and related neurological signs in the laboratory rat Can J Neurol Sci 6 2 209 215 1:STN:280:DyaL3c%2Fit1CmtQ%3D%3D 487313
13. S Kästner MF Oertel W Scharbrodt M Krause DK Böker W Deinsberger 2005 Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH Acta Neurochir (Wien) 147 12 1271 1279 10.1007/s00701-005-0633-0 discussion 1279
14. PA Kiener PM Davis JL Murray S Youssef BM Rankin M Kowala 2001 Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors Int Immunopharmacol 1 105 118 10.1016/S0162-3109(00)00272- 1 1:CAS:528:DC%2BD3MXhtlWnsbs%3D 11367508
15. Y Kureish Z Luo I Shiojima A Bialik D Fulton DJ Lefer WC Sessa K Walsh 2000 The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 1004 1010 10.1038/79510
16. U Laufs VL Fata JK Liao 1997 Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase J Biol Chem 272 31725 31729 10.1074/jbc.272.50.31725 1:CAS:528:DyaK2sXotVSkurY%3D 9395516
17. L Jk U Laufs 2005 Pleiotropic effects of statins Annu Rev Pharmacol Toxicol 45 89 118 10.1146/annurev.pharmtox.45.120403.095748
18. C Lindberg M Crisby B Winblad M Schultzberg 2005 Effects of statins on microglia J Neurosci Res 82 10 19 10.1002/jnr.20615 1:CAS:528:DC%2BD2MXhtFSrt7nL 16118799
19. JR Lynch H Wang MJ McGirt J Floyd AH Friedman AL Coon R Blessing MJ Alexander C Graffagnino DS Warner DT Laskowitz 2005 Simvastatin reduces vasospasm after aneurismal subarachnoid hemorrhage: results of a pilot randomized clinical trial Stroke 36 2024 2026 10.1161/01.STR.0000177879.11607.10 1:CAS:528:DC%2BD2MXovVKktr8%3D 16051891
20. P März U Otten AR Miserez 2007 Statins induce differentiation and cell death in neurons and astroglia Glia 55 1 12 10.1002/glia.20422 16998865
21. MR Mayberg T Okada DH Bark 1990 The role of hemoglobin in arterial narrowing after subarachnoid hemorrhage J Neurosurg 72 634 640 10.3171/jns.1990.72.4.0634 1:STN:280:DyaK3c3gsVShug%3D%3D 2319322
22. MJ McGirt JR Lynch A Parra H Sheng RD Pearlstein DT Laskowitz DA Pelligrino DS Warner 2002 Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage Stroke 33 2950 2965 10.1161/01.STR.0000038986.68044.39 1:CAS:528:DC%2BD38XptVSht74%3D 12468796
23. MJ McGirt R Blessing MJ Alexander SM Nimjee GF Woodworth AH Friedman C Graffagnino DT Laskowitz JR Lynch 2006 Risk of cerebral vasospasm after subarachnoid hemorrhage reduced by statin therapy: a multivariate analysis of an institutional experience J Neurosurg 105 671 674 10.3171/jns.2006.105.5.671 1:CAS:528:DC%2BD28Xht1eiu7zM 17121126
24. MJ McGirt G Pradilla FG Legnani QA Thai PF Recinos RJ Tamargo RE Clatterbuck 2006 Systemic administration of simvastatin after the onset of experimental subarachnoid hemorrhage attenuates cerebral vasospasm Neurosurgery 58 945 951 10.1227/01.NEU.0000210262.67628.7E 16639331
25. M Ohkita M Sugii Y Ka A Kitamura T Mori T Hayashi M Takaoka Y Matsumura 2006 Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells Exp Biol Med 231 6 772 776 1:CAS:528:DC%2BD28Xlt1ersrc%3D
26. E Ongini F Impagnatiello A Bonazzi M Guzzetta M Govoni A Monopoli P Del Soldato LJ Ignarro 2004 Nitric oxide (NO)-releasing statin derivatives; a class of drugs showing enhanced antiproliferative and anti-inflammatory properties Proc Natl Acad USA 101 8497 8502 10.1073/pnas.0401996101 1:CAS:528: DC%2BD2cXkvFOmt78%3D
27. TR Patel SA Corbett 2004 Simvastatin suppresses LPS-induced Akt phosphrylation in the human monocyte cell line THP-1 J Surg Res 116 116 120 10.1016/j.jss.2003.07.006 1:CAS:528:DC%2BD2cXltVGhsg%3D%3D 14732356
28. M Pelat C Dessy P Massion JP Desager O Feron JL Balligand 2003 Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E -/- mice in vivo Circulation 107 2480 2486 10.1161/01.CIR.0000065601.83526.3E 1:CAS:528:DC%2BD3sXjs1antL4%3D 12719275
29. Pezzini A, Del Zotto E, Volonghi I, Giossi A, Costa P, Padovani A (2009) New insights into the pleiotropic effects of statins for stroke prevention. Mini Rev Med Chem (7):794-804.
30. L Puglielli RE Tanzi DM Kovacs 2003 Alzheimer's disease: the cholesterol connection Nat Neurosci 6 345 351 10.1038/nn0403-345 1:CAS:528: DC%2BD3sXitlequrY%3D 12658281
31. RS Rosenson CC Tangney LC Casey 1999 Inhibition of proinflammatory cytokine production by pravastatin Lancet 353 245 257 10.1016/S0140-6736(98) 05917-0
32. J Sellner I Greeve O Findling CP Kamm C Minten B Engelhardt D Grandgirard SL Leib HP Mattle 2008 Effect of interferon-beta and atorvastatin on Th1/Th2 cytokines in multiple sclerosis Neurochem Int 53 1-2 17 21 10.1016/j.neuint. 2008.04.004 1:CAS:528:DC%2BD1cXnvVGqu7k%3D 18524417
33. T Shinichi S Osamu T Shigekazu F Yukihiko K Tetsuo T Ryuichi 1997 Detection of delayed cerebral vasospasm, after rupture of intracranial aneurysms, by magnetic resonance angiography Neurosurgery 40 4 748 754 10.1097/00006123-199704000-00017
34. T Sugawara R Ayer V Jadhav W Chen ZJH Tsubokawa 2008 Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase J Neurosci Res 86 3635 3643 10.1002/jnr.21807 1:CAS:528:DC%2BD1cXhsFaksLzP 18683242
35. T Tanaka I Tatsuno D Uchida I Moroo H Morio NY Nakamura T Yasuda M Kitagawa Y Saito A Harai 2000 Geranylgeranylpyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydoxy-3-methlyglutary-CoA reductase inhibition J Neursci 20 2852 2859 1:CAS:528:DC%2BD3cXisVertL0%3D
36. MY Tseng M Czosnyka H Richards JD Pickard PJ Kirkpatrick 2005 Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurismal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial Stroke 36 1627 1632 10.1161/01.STR. 0000176743.67564.5d 1:CAS:528:DC%2BD2MXmtlSqtbg%3D 16049199
37. VD Jc MJ Peters VP van Halm IE van der Horst-Bruinsma BA Dijkmans MT Nurmohamed 2006 Statin therapy might be beneficial for patients with ankylosing spondylitis Ann Rheum Dis 65 5 695 696 10.1136/ard.2005.044503
38. CJ Vaughan N Delanty 1999 Neuroprotective properties of statins in cerebral ischemia and stroke Stroke 30 1969 1973 1:CAS:528:DyaK1MXmtFKlsrw%3D 10471452
39. D Vauzour K Vafeiadou C Rice-Evans RJ Williams JP Spencer 2007 Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons J Neurochem 103 1355 1367 10.1111/j.1471-4159.2007.04841.x 1:CAS:528:DC%2BD2sXhtl2jurvE 17961201
40. J Wang T Tokoro K Matsui S Higa I Kitajima 2005 Pitavastatin at low dose activates endothelial nitric oxide synthase through PI3-AKT pathway in endothelial cells Life Sci 76 2257 2268 10.1016/j.lfs.2004.12.003 1:CAS:528:DC%2BD2MXhslejsr0%3D 15733940
41. X Wei X Chen C Fontanilla L Zhao Z Liang R Dodel H Hampel M Farlow Y Du 2007 C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line Life Sci 80 12 1152 1156 10.1016/j.lfs.2006.12.011 1:CAS:528:DC%2BD2sXitFCjurs%3D 17257626
42. S Wolfrum A Dendorfer M Schutt B Weidtmann A Heep K Tempel HH Llein P Dominiak G Richardt 2004 Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway J Cardiovas Pharmacol 44 348 355 10.1097/01.fjc.0000137162.14735.30 1:CAS:528:DC%2BD2cXntV2hs7g%3D