Alterations in the interaction between GAL4 and GAL80 effect regulation of the yeast GAL regulon mediated by the F box protein Dsg1

Current Microbiology

Volumn 61, Issue 3, 2010, Pages 210-216

  Li, Yan ^a   Chen, Guanjun ^a   Liu, Weifeng ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; F BOX PROTEIN; GALACTOSE; MITOCHONDRIAL PROTEIN; PROTEIN DNM1; PROTEIN DSG1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR GAL80; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA BINDING MOTIF; ENZYME ACTIVITY; FUNGAL STRAIN; FUNGUS GROWTH; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC CODE; GLUCOSE UTILIZATION; MITOCHONDRIAL GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULON; REPORTER GENE; TRANSCRIPTION REGULATION; YEAST;

AMINO ACID SUBSTITUTION; BETA-GALACTOSIDASE; DNA-BINDING PROTEINS; F-BOX PROTEINS; GALACTOSE; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, REPORTER; GTP PHOSPHOHYDROLASES; MITOCHONDRIAL PROTEINS; MUTATION, MISSENSE; PROTEIN BINDING; REGULON; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 77956189904     PISSN: 03438651     EISSN: 14320991     Source Type: Journal    
DOI: 10.1007/s00284-010-9598-1     Document Type: Article

References (23)

1. CT Archer A Delahodde F Gonzalez SA Johnston T Kodadek 2008 Activation domain-dependent monoubiquitylation of Gal4 protein is essential for promoter binding in vivo J Biol Chem 283 12614 12623 10.1074/jbc.M801050200 1:CAS:528:DC%2BD1cXltVyqt7s%3D 18326036
2. PJ Bhat TV Murthy 2001 Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction Mol Microbiol 40 1059 1066 10.1046/j.1365-2958.2001.02421.x 1:CAS:528:DC%2BD3MXksFCgt7Y%3D 11401712
3. MM Cohen GP Leboucher N Livnat MH Glickman AM Weissman 2008 Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion Mol Biol Cell 19 2457 2464 10.1091/mbc.E08-02-0227 1:CAS:528:DC%2BD1cXntV2rt78%3D 18353967
4. JC Corton E Moreno SA Johnston 1998 Alterations in the GAL4 DNA-binding domain can affect transcriptional activation independent of DNA binding J Biol Chem 273 13776 13780 10.1074/jbc.273.22.13776 1:CAS:528:DyaK1cXjvVejur0%3D 9593720
5. M Durr M Escobar-Henriques S Merz S Geimer T Langer B Westermann 2006 Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast Mol Biol Cell 17 3745 3755 10.1091/mbc.E06-01-0053 16790496
6. A Ferdous D Sikder T Gillette K Nalley T Kodadek SA Johnston 2007 The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters Genes Dev 21 112 123 10.1101/gad.1493207 1:CAS:528:DC%2BD2sXmsFyksw%3D%3D 17167105
7. A Ferdous M O'Neal K Nalley D Sikder T Kodadek SA Johnston 2008 Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and efficient promoter occupancy Mol Biosyst 4 1116 1125 10.1039/b809291e 1:CAS:528:DC%2BD1MXisFOntw%3D%3D 18931787
8. S Fritz N Weinbach B Westermann 2003 Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast Mol Biol Cell 14 2303 2313 10.1091/mbc.E02-12-0831 1:CAS:528:DC%2BD3sXkvFSlt7Y%3D 12808031
9. D Gietz A St Jean RA Woods RH Schiestl 1992 Improved method for high efficiency transformation of intact yeast cells Nucleic Acids Res 20 1425 10.1093/nar/20.6.1425 1:CAS:528:DyaK38XisV2mu7w%3D 1561104
10. F Gonzalez A Delahodde T Kodadek SA Johnston 2002 Recruitment of a 19S proteasome subcomplex to an activated promoter Science 296 548 550 10.1126/science.1069490 1:CAS:528:DC%2BD38XjtFCjsbc%3D 11964484
11. M Hirst MS Kobor N Kuriakose J Greenblatt I Sadowski 1999 GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8 Mol Cell 3 673 678 10.1016/S1097-2765(00)80360-3 1:CAS:528:DyaK1MXjslCqu7Y%3D 10360183
12. SA Johnston JM Salmeron Jr SS Dincher 1987 Interaction of positive and negative regulatory proteins in the galactose regulon of yeast Cell 50 143 146 10.1016/0092-8674(87)90671-4 1:CAS:528:DyaL1cXltVCmtQ%3D%3D 3297350
13. D Lohr P Venkov J Zlatanova 1995 Transcriptional regulation in the yeast GAL gene family: a complex genetic network FASEB J 9 777 787 1:CAS:528:DyaK2MXmvFCltbY%3D 7601342
14. J Ma M Ptashne 1987 The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80 Cell 50 137 142 10.1016/0092-8674(87)90670-2 1:CAS:528:DyaL1cXlt1Grtw%3D%3D 3297349
15. M Muratani C Kung KM Shokat WP Tansey 2005 The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing Cell 120 887 899 10.1016/j.cell.2004.12.025 1:CAS:528:DC%2BD2MXjtVOqtLY%3D 15797387
16. K Nalley SA Johnston T Kodadek 2006 Proteolytic turnover of the Gal4 transcription factor is not required for function in vivo Nature 442 1054 1057 10.1038/nature05067 1:CAS:528:DC%2BD28XovVyhtbk%3D 16929306
17. G Peng JE Hopper 2002 Gene activation by interaction of an inhibitor with a cytoplasmic signaling protein Proc Natl Acad Sci USA 99 8548 8553 10.1073/pnas.142100099 1:CAS:528:DC%2BD38XltF2hsrg%3D 12084916
18. A Platt RJ Reece 1998 The yeast galactose genetic switch is mediated by the formation of a Gal4p-Gal80p-Gal3p complex EMBO J 17 4086 4091 10.1093/emboj/17.14.4086 1:CAS:528:DyaK1cXltFygtLY%3D 9670023
19. Rose MD, Winston F, Heiter P (1990) Methods in yeast genetics: a laboratory course manual. Cold Spring Harbor Laboratory Press, Plainview, NY
20. I Sadowski D Niedbala K Wood M Ptashne 1991 GAL4 is phosphorylated as a consequence of transcriptional activation Proc Natl Acad Sci USA 88 10510 10514 10.1073/pnas.88.23.10510 1:CAS:528:DyaK38XjsFGltw%3D%3D 1961715
21. AK Sil S Alam P Xin L Ma M Morgan CM Lebo MP Woods JE Hopper 1999 The Gal3p-Gal80p-Gal4p transcription switch of yeast: Gal3p destabilizes the Gal80p-Gal4p complex in response to galactose and ATP Mol Cell Biol 19 7828 7840 1:CAS:528:DyaK1MXmvFekuro%3D 10523671
22. K Yano T Fukasawa 1997 Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae Proc Natl Acad Sci USA 94 1721 1726 10.1073/pnas.94.5.1721 1:CAS:528:DyaK2sXhslaksr8%3D 9050845
23. FT Zenke R Engles V Vollenbroich J Meyer CP Hollenberg KD Breunig 1996 Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p Science 272 1662 1665 10.1126/science.272.5268.1662 1:CAS:528: DyaK28Xjs1ejurc%3D 8658143