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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5376-5379

Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands

(11) Jean, Mickaël a Renault, Jacques a Levoin, Nicolas b Danvy, Denis b,c Calmels, Thierry b Berrebi Bertrand, Isabelle b Robert, Philippe b Schwartz, J C b Lecomte, J M b Uriac, Philippe a Capet, Marc b

a UNIVERSITÉ DE RENNES 1 (France)

b Bioprojet Biotech (France)

c IRCOF (France)

Author keywords

Amide isoster; Dopamine D3 receptor ligand; Selectivity

Indexed keywords

4' ACETYL N [4 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]BUTYL]BIPHENYL 4 CARBOXAMIDE; A 690344; A 706149; AMIDE; BP 897; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; FAUC 349; NGB 2904; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CLINICAL EVALUATION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT;

AMIDES; ANIMALS; BRAIN; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; PIPERAZINES; RATS; RECEPTORS, DOPAMINE D3;

EID: 77956177883 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.07.096 Document Type: Article

Times cited : (8)

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- note
- 3H] prazosin using 5 μg of membrane suspension (prepared from stable human hADRA1A transfected cell line). All assays were performed at least in duplicate. Mean values are given.

20
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- 3): 8.1 (doublet, 1H); 7.65-7.55 (unresolved peaks, 2H); 7.5-7.25 (unresolved peaks, 4H); 7.2-7.0 (unresolved peaks, 3H); 6.8 (doublet, 1H); 6.55 (singlet, 1H); 4.8 (wide triplet, 1H); 3.35 (multiplet, 2H); 3.35-3.15 (unresolved peaks, 4H); 2.7-2.55 (unresolved peaks, 4H); 2.45 (triplet, 2H); 1.85-1.65 (unresolved peaks, 4H).

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