Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: Studies in rat and ferret isolated muscles

Circulation Research

Volumn 83, Issue 1, 1998, Pages 50-59

  Cittadini, Antonio ^a,e   Ishiguro, Yoshiki ^a   Strömer, Hinrik ^a   Spindler, Matthias ^c   Moses, Alan C ^b   Clark, Ross ^d   Douglas, Pamela S ^a   Ingwall, Joanne S ^c   Morgan, James P ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d GENENTECH INC   (United States)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Aequorin; Ca2+; Heart; Inotropy; Insulin like growth factor 1; Somatotropin

Indexed keywords

AEQUORIN; CALCIUM; GROWTH HORMONE; SOMATOMEDIN C; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; HEART MUSCLE CONTRACTILITY; HIGH ENERGY PHOSPHATE; INOTROPISM; MALE; MUSCLE ISOTONIC CONTRACTION; MUSCLE TETANIC CONTRACTION; MYOFILAMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; RAT; STEADY STATE;

EID: 0032514277     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.83.1.50     Document Type: Article

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