An evaluation of a cultured human corneal epithelial tissue model for the determination of the ocular irritation potential of pharmaceutical process materials

Toxicology in Vitro

Volumn 24, Issue 6, 2010, Pages 1862-1870

  Seaman, Christopher W ^a   Whittingham, Andrew ^b   Guest, Robert ^b   Warren, Neil ^b   Olson, Michael J ^c   Guerriero, Frederick J ^c   Adriaens, Els ^d   De Wever, Bart ^e  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Harlan   (Switzerland)

^c GLAXOSMITHKLINE   (United States)

^d GHENT UNIVERSITY   (Belgium)

^e CARDAM   (Belgium)

Author keywords

Alternative method; Eye irritation; In vitro methods; Occupational hazard assessment

Indexed keywords

(9 BETA,11 BETA,16 BETA) 9,11 EPOXY 17,21 DIHYDROXY 16 METHYL PREGNA 1,4 DIENE 3,20 DIONE; 1 (9H CARBAZOL 4 YLOXY) 3 [[2 (2 METHOXYPHENOXY)ETHYL] (PHENYLMETHYL)AMINO] 2 PROPANOLOL; 1 DIPHENYLMETHYL 4 METHYLPIPERAZINE; 2 BROMO 6 METHOXYNAPHTHALENE; 2,3 DICHLORO 5,6 DICYANO 1,4 BENZOQUINONE; 2,3 DIHYDROXYSUCCINIC ACID 3 [(1,3 BENZODIOXOL 5 YLOXY)METHYL] 4 (4 FLUOROPHENYL) 1 METHYLPIPERADINE; 4 (5) HYDROXYMETHYL 5 (4) METHYL IMIDAZOLE; 4 FLUOROBENZALDEHYDE; 5 [4 [2 [N METHYL N (2 PYRIDYL)AMINO]ETHOXY]BENZYL]THIAZOLIDINE 2,4 DIONE 2 BUTANEDIOATE; ACICLOVIR; CHEMICAL COMPOUND; CHLOROACETONITRILE; INTERLEUKIN 1ALPHA; LAMOTRIGINE; METHYL 3 (METHYLAMINO) 3 OXOPROPANOATE ETHYL ACETATE; METHYLCYCLOHEXANE; METOCLOPRAMIDE; N CYANO S METHYL N' [2 (4 METHYL)METHYLTHIOETHYL]ISOTHIOUREA HYDRATE; OXYBENZONE; PSEUDOEPHEDRINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOTOXICITY TEST; EYE IRRITATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PREDICTION; PROTEIN EXPRESSION; SCREENING TEST; SENSITIVITY AND SPECIFICITY; TISSUE CULTURE;

ANIMAL TESTING ALTERNATIVES; CELL SURVIVAL; CELLS, CULTURED; EPITHELIUM, CORNEAL; HUMANS; IRRITANTS; NECROSIS; PHARMACEUTICAL PREPARATIONS; TETRAZOLIUM SALTS; THIAZOLES; XENOBIOTICS;

ORYCTOLAGUS CUNICULUS;

EID: 77956170662     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.03.004     Document Type: Article

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