Modulation of synaptic transmission and analysis of neuroprotective effects of valproic acid and derivates in rat embryonic motoneurons

Cellular and Molecular Neurobiology

Volumn 30, Issue 6, 2010, Pages 891-900

  Ragancokova, D ^a,c   Song, Y ^a,c   Nau, H ^b   Dengler, R ^a,c   Krampfl, K ^a,c   Petri, S ^a,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^c CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Excitatory postsynaptic currents (EPSC); Excitotoxicity; Glial cells; Inhibitory postsynaptic currents (IPSC); Motoneurons; Valproic acid and derivates

Indexed keywords

2 PENTYL 4 PENTENOIC ACID; 3 PROPYL HEPTANOIC ACID; KAINIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID; VALPROIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; DRUG STRUCTURE; EMBRYO; ENANTIOMER; EXCITOTOXICITY; IN VITRO STUDY; INCUBATION TIME; MOTONEURON; NERVE CELL CULTURE; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SCHWANN CELL; SYNAPTIC TRANSMISSION;

ANIMALS; CELLS, CULTURED; EMBRYO, MAMMALIAN; MOTOR NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SYNAPTIC TRANSMISSION; VALPROIC ACID;

RATTUS;

EID: 77956144172     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-010-9518-8     Document Type: Article

References (42)

1. A Araque RP Sanzgiri, et al. 1999 Astrocyte-induced modulation of synaptic transmission Can J Physiol Pharmacol 77 9 699 706 10.1139/cjpp-77-9-699 1:CAS:528:DyaK1MXntlOls74%3D 10566947
2. V Arce RA Pollock, et al. 1998 Synergistic effects of Schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1) J Neurosci 18 4 1440 1448 1:CAS:528:DyaK1cXptlyjsQ%3D%3D 9454853
3. C Bendotti MT Carri 2009 Amyotrophic lateral sclerosis: mechanisms and countermeasures Antioxid Redox Signal 11 7 1519 1522 10.1089/ars.2009.2620 1:CAS:528:DC%2BD1MXmsVCmt74%3D 19358631
4. RA Blaheta M Michaelis, et al. 2005 Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies Med Res Rev 25 4 383 397 10.1002/med.20027 1:CAS:528:DC%2BD2MXntlSktbg%3D 15637697
5. SL Buldakova DB Tikhonov, et al. 2005 Analysis of the excitatory and inhibitory components of postsynaptic currents recorded in pyramidal neurons and interneurons in the rat hippocampus Neurosci Behav Physiol 35 8 835 843 10.1007/s11055-005-0133-y 1:CAS:528:DC%2BD2MXhtFyqt7jF 16132265
6. CL Chen J Sung, et al. 2006 Valproic acid inhibits invasiveness in bladder cancer but not in prostate cancer cells J Pharmacol Exp Ther 319 2 533 542 10.1124/jpet.106.106658 1:CAS:528:DC%2BD28XhtFOkurzE 16868035
7. AM Clement MD Nguyen, et al. 2003 Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science 302 5642 113 117 10.1126/science.1086071 1:CAS:528:DC%2BD3sXnslSjsLo%3D 14526083
8. C Crochemore M Virgili, et al. 2009 Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis Muscle Nerve 39 4 548 552 10.1002/mus.21260 1:CAS:528:DC%2BD1MXkvFentL0%3D 19296491
9. MO Cunningham GL Woodhall, et al. 2003 Valproate modifies spontaneous excitation and inhibition at cortical synapses in vitro Neuropharmacology 45 7 907 917 10.1016/S0028-3908(03)00270-3 1:CAS:528:DC%2BD3sXot1yrsb4%3D 14573383
10. H Deubzer B Busche, et al. 2006 Novel valproic acid derivatives with potent differentiation-inducing activity in myeloid leukemia cells Leuk Res 30 9 1167 1175 10.1016/j.leukres.2006.01.009 1:CAS:528:DC%2BD28XntV2gurc%3D 16510182
11. FP Di Giorgio MA Carrasco, et al. 2007 Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat Neurosci 10 5 608 614 10.1038/nn1885 1:CAS:528:DC%2BD2sXksFShsLg%3D 17435754
12. H Dou K Birusingh, et al. 2003 Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis J Neurosci 23 27 9162 9170 1:CAS:528:DC%2BD3sXotFOmsLw%3D 14534250
13. BJ Eickholt GJ Towers, et al. 2005 Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure Mol Pharmacol 67 5 1426 1433 10.1124/mol.104.009308 1:CAS:528:DC%2BD2MXktFegsb4%3D 15687223
14. HC Gallagher OA Odumeru, et al. 2000 Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta J Neurosci Res 61 6 636 645 10.1002/1097-4547(20000915)61:6<636::AID- JNR7>3.0.CO;2-F 1:CAS:528:DC%2BD3cXmsVygsb8%3D 10972960
15. K Gotfryd S Owczarek, et al. 2007 Multiple effects of pentyl-4-yn-VPA enantiomers: from toxicity to short-term memory enhancement Neuropharmacology 52 3 764 778 10.1016/j.neuropharm.2006.09.017 1:CAS:528:DC%2BD2sXhvVyqtrc%3D 17095022
16. K Haastert J Grosskreutz, et al. 2005 Rat embryonic motoneurons in long-term co-culture with Schwann cells-a system to investigate motoneuron diseases on a cellular level in vitro J Neurosci Methods 142 2 275 284 10.1016/j.jneumeth.2004.09.003 15698667
17. RS Hauck H Nau 1992 The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice Pharm Res 9 7 850 855 10.1023/A:1015832411981 1:CAS:528:DyaK38Xls1eltbk%3D 1437995
18. M Hollmann M Hartley, et al. 1991 Ca2 + permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition Science 252 5007 851 853 10.1126/science.1709304 1:CAS:528:DyaK3MXksVamsL0%3D 1709304
19. K Jahn J Grosskreutz, et al. 2006 Temporospatial coupling of networked synaptic activation of AMPA-type glutamate receptor channels and calcium transients in cultured motoneurons Neuroscience 142 4 1019 1029 10.1016/j.neuroscience.2006.07.034 1:CAS:528:DC%2BD28XhtFCjsLfO 16949760
20. CU Johannessen 2000 Mechanisms of action of valproate: a commentatory Neurochem Int 37 2-3 103 110 10.1016/S0197-0186(00)00013-9 1:CAS:528: DC%2BD3cXksF2gsb0%3D 10812195
21. A Lampen PA Grimaldi, et al. 2005 Modulation of peroxisome proliferator-activated receptor delta activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation Mol Pharmacol 68 1 193 203 1:CAS:528:DC%2BD2MXlvVSqurY%3D 15829700
22. Y Leng DM Chuang 2006 Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity J Neurosci 26 28 7502 7512 10.1523/JNEUROSCI.0096-06.2006 1:CAS:528:DC%2BD28XnsVWnurw%3D 16837598
23. ML Martin CM Regan 1991 The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase Brain Res 554 1-2 223 228 10.1016/0006-8993(91)90193-Y 1:CAS:528:DyaK3MXlsFShsb4%3D 1933304
24. KD McCarthy J de Vellis 1980 Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue J Cell Biol 85 3 890 902 10.1083/jcb.85.3.890 1:CAS:528:DyaL3cXkvFaltL0%3D 6248568
25. KJ Murphy CM Regan 1998 Contributions of cell adhesion molecules to altered synaptic weightings during memory consolidation Neurobiol Learn Mem 70 1-2 73 81 10.1006/nlme.1998.3839 1:CAS:528:DyaK1cXmslyru7k%3D 9753588
26. KJ Murphy GB Fox, et al. 2001 Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe J Neurochem 78 4 704 714 10.1046/j.1471-4159.2001.00411.x 1:CAS:528:DC%2BD3MXmt1egs78%3D 11520891
27. M Nagai DB Re, et al. 2007 Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons Nat Neurosci 10 5 615 622 10.1038/nn1876 1:CAS:528:DC%2BD2sXksFShs7c%3D 17435755
28. CM Ni Dhuill GB Fox, et al. 1999 Polysialylated neural cell adhesion molecule expression in the dentate gyrus of the human hippocampal formation from infancy to old age J Neurosci Res 55 1 99 106 10.1002/(SICI)1097-4547(19990101) 55:1<99::AID-JNR11>3.0.CO;2-S 1:CAS:528:DyaK1MXjtlSmsQ%3D%3D 9890438
29. ED O'Loinsigh LM Gherardini, et al. 2004 Differential enantioselective effects of pentyl-4-yn-valproate on spatial learning in the rat, and neurite outgrowth and cyclin D3 expression in vitro J Neurochem 88 2 370 379 10.1111/j.1471-4159.2004.02158.x 14690525
30. WM Pardridge T Yoshikawa, et al. 1994 Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs J Pharmacol Exp Ther 268 1 14 18 1:CAS:528:DyaK2cXhsFaqt74%3D 8301550
31. S Petri M Kiaei, et al. 2006 Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis Neurobiol Dis 22 1 40 49 10.1016/j.nbd.2005.09.013 1:CAS:528:DC%2BD28XivVOjtb4%3D 16289867
32. D Ragancokova K Jahn, et al. 2009 Analysis of neuroprotective effects of valproic acid on primary motor neurons in monoculture or co-cultures with astrocytes or Schwann cells Cell Mol Neurobiol 29 6-7 1037 1043 10.1007/s10571-009-9393-3 1:CAS:528:DC%2BD1MXptFClu7Y%3D 19330445
33. SD Rao JH Weiss 2004 Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis Trends Neurosci 27 1 17 23 10.1016/j.tins.2003.11.001 1:CAS:528:DC%2BD3sXhtVShs7bJ 14698606
34. D Rochon I Rousse, et al. 2001 Synapse-glia interactions at the mammalian neuromuscular junction J Neurosci 21 11 3819 3829 1:CAS:528: DC%2BD3MXjvFGlsrY%3D 11356870
35. C Rouaux I Panteleeva, et al. 2007 Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model J Neurosci 27 21 5535 5545 10.1523/JNEUROSCI.1139-07.2007 1:CAS:528:DC%2BD2sXmsVWnsro%3D 17522299
36. H Ryu K Smith, et al. 2005 Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice J Neurochem 93 5 1087 1098 10.1111/j.1471-4159.2005.03077.x 1:CAS:528:DC%2BD2MXltVans74%3D 15934930
37. M Saladini MA Gabana, et al. 1981 Effect of antiepileptic drugs on the cerebral amino acid uptake in vitro Ital J Neurol Sci 2 4 351 360 1:STN:280:DyaL387ktFCrug%3D%3D 6120919
38. F Sugai Y Yamamoto, et al. 2004 Benefit of valproic acid in suppressing disease progression of ALS model mice Eur J Neurosci 20 11 3179 3183 10.1111/j.1460-9568.2004.03765.x 15579172
39. LK Tsai CC Yang, et al. 2007 Valproic acid treatment in six patients with spinal muscular atrophy Eur J Neurol 14 12 e8 e9 10.1111/j.1468-1331.2007. 01992.x 18028187
40. L Van Den Bosch W Robberecht 2008 Crosstalk between astrocytes and motor neurons: what is the message? Exp Neurol 211 1 1 6 10.1016/j.expneurol.2008.01. 008
41. L Van Den Bosch P Van Damme, et al. 2006 The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis Biochim Biophys Acta 1762 11-12 1068 1082
42. W Vandenberghe L Van Den Bosch, et al. 1998 Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system Brain Res 807 1-2 1 10 10.1016/S0006-8993(98)00569-1 1:CAS:528: DyaK1cXmtFWisbY%3D 9756982