Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe

Journal of Neurochemistry

Volumn 78, Issue 4, 2001, Pages 704-714

  Murphy, Keith J ^a   Fox, Gerard B ^a   Foley, Andrew G ^a   Gallagher, Helen C ^a   O'Connell, Alan ^a   Griffin, Anne Marie ^a   Nau, Heinz ^b   Regan, Ciaran M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

2 N pentyl 4 pentynoic acid; Cognition enhancer; NCAM polysialylation; Passive avoidance; Valproate; Water maze

Indexed keywords

NERVE CELL ADHESION MOLECULE; PENTYL 4 YN VALPROIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVOIDANCE BEHAVIOR; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; ESCAPE BEHAVIOR; MALE; MAZE TEST; MEMORY CONSOLIDATION; NERVE CELL CULTURE; NERVE CELL GROWTH; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; SPATIAL MEMORY; SYNAPSE;

AGING; ANIMALS; AVOIDANCE LEARNING; BLOOD PRESSURE; CELL LINE; HEART RATE; HIPPOCAMPUS; KIDNEY; LIVER; LUNG; MALE; MAZE LEARNING; MUSCARINIC ANTAGONISTS; NEURAL CELL ADHESION MOLECULES; NEURONAL PLASTICITY; NEURONS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; SCOPOLAMINE; TEMPORAL LOBE; VALPROIC ACID;

EID: 0034887564     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00411.x     Document Type: Article

References (49)

1. 125I-neurotrophin-3 binding to mammalian brain
2. Heterogeneity of adverse hepatic reactions to tetra hydroaminoacridine
3. Age-related changes in expression of the neural cell adhesion molecule in skeletal muscle: A comparative study of newborn, adult and aged rats
4. Effects of nimodipine on the cognitive dysfunction induced by phenytoin and valproate in rats
5. The polysialic acid modification of the neural cell adhesion molecule is involved in spatial learning and hippocampal long-term potentiation
6. Studies on the teratogen pharmacophore of valproic acid analogues: Evidence of interactions at a hydrophobic centre
7. Intravenous drug self-administration techniques in animals
8. Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children
9. Impact of valproate and phenytoin on cognitive function in elderly patients: Results of a single-blind randomized comparative study
10. Marked accumulation of valproic acid in embryonic neuroepithelium of the mouse during early organogenesis
11. Comparison of the effects of NGF, activators of protein kinase C, and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cultures
12. Neurite outgrowth in response to transfected NCAM changes during development is modulated by polysialic acid
13. Cholinergic and dopaminergic agents which inhibit a passive avoidance response attenuate the paradigm-specific increases in NCAM sialylation state
14. Intraventricular infusions of anti-neural cell adhesion molecules in a discrete posttraining period impair consolidation of a passive avoidance response in the rat
15. Tacrine in Alzheimer's disease
16. Polysialylated neural cell adhesion molecule expression by neurons and astroglial processes in the rat dentate gyrus declines dramatically with increasing age
17. Memory consolidation induces a transient and time-dependent increase in the frequency of NCAM polysialylated cells in the adult rat hippocampus
18. Consolidation of passive avoidance learning is associated with transient increases of polysialylated neurons in layer II of the rat medial temporal cortex
19. Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta
20. Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities
21. The anticonvulsant valproic acid concentrates in the olfactory bulb: Selective laminar localization
22. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
23. Modality-specific retrograde amnesia of fear
24. Pressor and bradycardic effects of tacrine and other acetylcholinesterase inhibitors
25. The effect of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus
26. Localization of nerve growth factor, trkA and P75 immunoreactivity in the hippocampal formation and basal forebrain of rats
27. Valproate: A reappraisal of its pharmacodynamic properties and mechanisms of action
28. Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM
29. The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase
30. Contrasts between the cardiovascular concomitants of tests of planning and attention
31. Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus
32. Repetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multi-trial spatial training
33. Polysialylated neural cell adhesion molecule expression in the dentate gyrus of the human hippocampal formation from infancy to old age
34. Spatial learning activates neural cell adhesion molecule polysialylation in a cortico-hippocampal pathway within the medial temporal lobe
35. Influence of nefiracetam on NGF-induced neuritogenesis and neural cell adhesion molecule polysialic acid expression: In vivo and in vitro comparisons
36. Ultrastructural analysis reveals avoidance conditioning to induce a transient increase in hippocampal dentate spine density in the 6 h posttraining period of consolidation
37. Transient spine density increases in the mid-molecular layer of the hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent
38. New approaches to drug delivery through the blood-brain barrier
39. Turnover studies of the neural cell adhesion molecule NCAM: Degradation of NCAM in PC12 cells depends on the presence of NGF
40. Cardiovascular and endocrine responses to experimental stress: Effects of mental effort and controllability
41. Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin
42. NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1
43. A monoclonal antibody against meningococcus group B polysaccharides distinguishes embryonic from adult NCAM
44. A role for the neural cell adhesion molecule in a late, consolidating phase of glycoprotein synthesis six hours following passive avoidance training of the young chick
45. Increase in proportion of hippocampal spine synapses expressing neural cell adhesion molecule NCAM180 following long-term potentiation
46. Increased immunogold labelling of neural cell adhesion molecule isoforms in synaptic active zones of the chick striatum 5-6 hours after one-trial passive avoidance training
47. Cell surface expression of polysialic acid on NCAM is a prerequisite for activity-dependent morphological neuronal and glial plasticity
48. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
49. Nefiracetam (DM-9384): A novel antiamnesic drug