An Evaluation of influence of Citrus paradisi seed extract on doxorubicin-induced testicular oxidative stress and impaired Spermatogenesis

Asian Journal of Scientific Research

Volumn 3, Issue 1, 2010, Pages 51-61

  Saalu, L C ^a   Osinubi, A A ^b   Jewo, P I ^a   Oyewopo, A O ^c   Ajayi, G O ^a  

^a LAGOS STATE UNIVERSITY   (Nigeria)

^b UNIVERSITY OF LAGOS   (Nigeria)

^c UNIVERSITY OF ILORIN   (Nigeria)

Author keywords

Citrus paradisi; Doxorubicin; Oxidative stress; Spermatogenesis

Indexed keywords

EID: 77956144153     PISSN: 19921454     EISSN: None     Source Type: Journal    
DOI: 10.3923/ajsr.2010.51.61     Document Type: Article

References (47)

1. Aebi, H.E., 1983. Catalase. In: Methods of Enzymatic Analysis, Bergmeyer, H.U. (Ed.). Verlag Chemie, Weinhem, pp: 273-286.
2. American Physiological Society, 2002. Guiding principles for research involving animals and human beings. Am. J. Physiol. Regul. Integr. Comp. Physiol., 283: R281-R283.
3. Armando, C, S. Maythe and N.P. Beatriz, 1997. Antioxidant activity of grapefruit extract on vegetable oils. J. Sci. Food Agric, 77: 463-467.
4. Armstrong, L.L. and RJ. Lipsy, 1993. Doxorubicin. Drug Information Handbook, Lexi-Comp, Husdon.
5. Atessahin, A., I. Karahan, G. Turk, S. Gur, S. Yilmaz and A.O. Ceribasi, 2006. Protective role of lycopene on cisplatin induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod. Toxicol., 21: 42-47.
6. Banerjee, H.N. and M. Verma, 2008. Application of nanotechnology in cancer. Technol Cancer Res. Treat, 7: 149-154.
7. Berthiaume, J.M. and K.B. Wallace, 2007. Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biol. Toxicol., 23: 15-25.
8. Bonadonna, G., M. Zambetti and P. Valagussa, 1996. Sequential or alternating doxorubcm and CMF regimens in breast cancer with more than three positive nodes: Ten-years results. J. Am. Med. Assoc, 273: 542-547.
9. Bromberg, L., 2008. Polymeric micelles in oral chemotherapy. J Control Release, 128: 99-112.
10. Buege, J.A. and S.D. Aust, 1978. Microsomal Lipid Peroxidation. In: Methods of Enzymology, Fleischer, S. and L. Packer (Eds.), Academic Press, New York, pp: 302-310.
11. Canadian Council of Animal Care, 1985. Guide to the Handling and use of Experimental Animals. Vol. 23, NIH Publications, Ottawa, USA., pp: 45-47.
12. Chularojmontri, L., S.K. Wattanapitayakul, A. Herunsalee, S. Charuchongkolwongse, N. Niumsakul and S. Snchairat, 2005. Antioxidative and cardioprotective effects of Phyllanihus urinaria L. on doxorubicin-induced cardiotoxicity. Biol. Pharm. Bull., 28: 1165-1171.
13. Davies, K.J. and J.H. Doroshow, 1986. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J. Biol. Chem., 261: 3060-3067.
14. Dowling, C. F. and J.F. Morton, 1987. Fruits of Warm Climates. 2nd Edn., J.F. Morton, Miami, Fla, pp: 18-28.
15. Duncan, B.D., 1957. Multiple range tests for correlated and heteroscedastic means. Biometrics, 13: 164-176.
16. Ellman, G.L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys., 82: 70-77.
17. Endo, F., F. Manabe, H. Takeshima and H. Akaza, 2003. Protecting spermatogonia from apoptosis induced by doxorubicme using the luteimzing hormone-releasing hormone analog leuprorelin. Int. J. Urol., 10: 72-77.
18. Ferderick, C. A., L.D. Williams, G. Ughetto, G.A. van der Marel, J.H. van Boom, A. Rich and A.H.J. Wang, 1990. Structural comparison of anticancer drug-DNA complexes: Adriamycin and daunomycm. Biochem. J., 29: 2538-2549.
19. Halliwell, B., 2008. Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch. Biochem. Biophys., 476: 107-112.
20. Heggers, J.P., J. Cottingham, J. Gusman, L. Reagor and L. McCoy et al., 2002. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. J. Altern Compl. Med., 8: 333-340.
21. Heller, C.G. and Y. Clermont, 1964. Spermatogenesis in man: An estimate of its duration. Science, 140: 184-186.
22. Jain, K.K., 2005. Targeted drug delivery for cancer. Technol. Cancer Res. Treatment, 4:311-313.
23. Jegou, B., C. Pineau and J. Toppari, 2002. Spermatogenesis in vitro in Mammals. In: Assisted Reproductive Technology: Accomplishments and New Horizons, De Jonge, C.J. and C.L.R. Barratt(Eds.). 1st Edn., Cambridge University Press, Cambridge, UK., pp: 3-60.
24. Kalender, Y. and M. Yel, 2005. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: The effects of vitamin E and catechin. Toxicology, 209: 39-45.
25. Kato, M., S. Makino, H. Kimura and T. Ota, 2001. Sperm motion analysis in rats treated with adriamycm and its applicability to male reproductive toxicity studies. J. Toxicol. Sci., 26:51-59.
26. Mornparler, R.L., M. Karon, S.E. Siegel andF. Avila, 1976. Effect of Adriamycm on DNA, RNA and Protein synthesis in cell free systems and intact cells. Cancer Res., 36: 2891-2895.
27. Ng, R., N. Better and M.D. Green, 2006. Anti-cancer agents and cardiotoxicity. Semin. Oncol., 33: 2-14.
28. Pacher, P., 2007. FRs induce Chain reaction. Physiol. Rev., 87: 315-424.
29. Pigram, W.J., W. Fuller and L.D. Hamilton, 1972. Stereochemistry of intercalation: Interaction of daunomycin with DNA. Nat. New Biol., 235: 17-19.
30. Prahalathan, C, E. Selvekuma and P. Varalakshmi, 2005. Lipoic acid ameliorates adriamycin-induced testicular mitochondriopathy. Reprod. Toxicol., 20: 111-116.
31. Pnestman, T., 2008. Cancer Chemotherapy in Clinical Practice. Springer-Verlag, London, UK., pp:130-136.
32. Quiles, J.L., J.R. Huertas, M. Battino, J. Mataix and CM. Ramirez-Tortosa, 2002. Antioxidant nutrients and adriamycin toxicity. Toxicology, 180: 79-95.
33. Rotruck, IT., A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman and W.G. Hoekstra, 1973. Selenium: Biochemical role as a component of glutathione peroxidase. Science, 179: 588-590.
34. Rukmini, M.S., I. Benedict and D. Vivian, 2004. Superoxide dismutase and catalase activities and their correlation with malondialdehyde in Scizophrenic patients. Ind. J. Clin. Biochem., 19: 114-118.
35. Saalu, L.C., G.O. Ajayi, A.A. Adeneye, I.O. Imosemi and A.A. Osinubi, 2009a. Ethanol seed extract of grapefruit (Citrus paradisi) as an effective attenuator of doxorubicin-induced oxidative stress mthe rat heart. Int. J. Cancer Res., 5: 44-52.
36. Saalu, L.C., L.A. Enye and A.A. Osinubi, 2009b. An assessment of the histomorphometric evidences of doxorubicin-induced testicular cytotoxicity in Wistar rats. Int. J. Med. Med. Sci., 1:370-374.
37. Sachs, A., 1997. The Authoritative Guide to Grapefruit Extract. Stay Healthy Naturally, Life rhythm, Medocino, California, pp: 775-795.
38. Sikka, S.C., 1996. Oxidating stress and role of antioxidants in normal and abnormal sperm function. Front Bisobene, 1: 78-86.
39. Singh, K.K., 2005. Nanotechnology in cancer detection and treatment. Technol. Cancer Res. Treat. 4: 583-584.
40. Snedecor, G.W. and W.G. Cochran, 1980. Statistical Method. 7th Edn, Iowa State University Press, Ames, Iowa, USA., pp: 507.
41. Sonmez, M., G. Turk and A. Yuce, 2005. The effect of ascorbic acid supplementation on sperm quality, hpid peroxidation and testosterone levels of male Wistar rats. Theriogenology, 63: 2063-2072.
42. Suominen J.S., J. Linderborg, J. Nikula, H. Hakovirta, H. Parvinen and J. Toppari, 2003. The effects of mono-2-ethylhexyl phathalate, adriamycm and N-ethyl-nitrosouria on stage-specific apoptosis and DNA synthesis in the mouse spermatogenesis. Toxicol. Lett., 143: 163-173.
43. Ursini, F., F. Tubaro, J. Rong and A. Sevanian, 1999. Optimization of nutrition: Polyphenols and vascular protection. Nutr. Rev., 57: 241-249.
44. Winterbourn, C.C., R.E. Hawkins, M. Brian andR.W. Carrell, 1975. The estimation of red cell superoxide dismutase activity. J. Lab. Clin. Med., 85: 337-341.
45. Wolinsky, J.B. and M.W. Grinstaff, 2008. Therapeutic and diagnostic applications of dendrimers for cancer treatment. Adv. Drug Dehv. Rev., 60: 1037-1055.
46. Yeh, Y.C., L. Hui-Chi and T. Chih-Tai, 2007. The effects of Doxocycline on Doxorubcin induced oxidative damage and apoptosis in mouse testis. Biol. Reprod, 77: 217-217.
47. Yokoi, K. andZ.K. Mayi, 2004. Organ apoptosis with cytotoxic drugs. Toxicology, 290: 78-85.