Chitosan microspheres of aceclofenac: In vitro and in vivo evaluation

Pharmaceutical Development and Technology

Volumn 15, Issue 5, 2010, Pages 442-451

  Nagda, Chirag ^a   Chotai, Narendra ^b   Patel, Sandip ^a   Nagda, Dhruti ^b   Patel, Upendra ^c,d   Soni, Tejal ^a  

^a Indukaka Ipcowala College of Pharmacy   (India)

^b AR Patel and GH Patel Institute of Pharmacy   (India)

^c Arihant School of Pharmacy and Bioresearch Institute   (India)

^d Anand College of Pharmacy   (India)

Author keywords

Aceclofenac; Chitosan; Double emulsion solvent evaporation; Histopathology; In vitro release; Microspheres

Indexed keywords

ACECLOFENAC; CHITOSAN; MICROSPHERE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; EMULSION; EROSION; EVALUATION; EVAPORATION; GASTROINTESTINAL TRACT; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MICROENCAPSULATION; MUCOADHESION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE FORMULATION; THERMOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DELAYED-ACTION PREPARATIONS; DICLOFENAC; DIFFUSION; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; RATS; RATS, WISTAR; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 77956143469     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450903286503     Document Type: Article

References (37)

1. Kyo M, Hyon S, Ikada Y. Efect of preparation conditions of cisplatin-loaded microspheres on the in vitro release. J Control Release 1995:35:73-82.
2. Patel JK, Patel RP, Amin A F, Patel MM. Formulation and evaluation of mucoadhesive glipizide microspheres. AAPS Pharm Sci Tech 2005;6(1):E49-55.
3. Chuo WH, Tsai TR, Hsu SH, Cham TM. Development of nifedipine-loaded albumin microspheres using a statistical factorial design. Int J Pharm 1996;134:247-251.
4. Bayomi MA, Al-Suwayeh SA, El-Helw AM, Mesnad AF. Preparation of casein-chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique. Pharm Acta Helv 1998;73:187-192.
5. Wang J, Tabata Y, Bi D, Morimoto K. Evaluation of gastric mucoadhesive properties of aminated gelatin microspheres. J Control Release 2001;73:223-231.
6. Ko JA, Park HJ, Hwang SJ, Park JB, Lee JS. Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm 2002;249:165-174.
7. Agnihotri SA, Aminabhavi TM. Novel interpenetrating network chitosan-poly (ethylene oxide-g-acrylamide) hydrogel micro-spheres for the controlled release of capecitabine. Int J Pharm 2006;324:103-115.
8. Mi FL, Wong TB, Shyu SS, Chang SF. Chitosan microspheres: modifcation of polymeric chem-physical properties of spray-dried microspheres to control the release of antibiotic drug. J Appl Polym Sci Symp 1999;71:747-759.
9. He P, Davis S, Illum L. In vitro evaluation of the mucoad-hesive properties of chitosan microspheres. Int J Pharm 1998;166:75-88.
10. Kulkarni P V, Keshavayya J, Kulkarni VH. Efect of method of preparation and process variables on controlled release of insoluble drug from chitosan microspheres. Polym Adv Technol 2007;18:814-821.
11. Desai KG, Park HJ. Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying. Drug Dev Res 2005;64:114-128.
12. Sandra K, Gareth DR, John T, Smart JD. Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: Preparation and controlled release characteristics. Eur J Pharm Biopharm 2005;59:207-216
13. Parftt K.Analgesics anti-infammatory and antipyretics. In: Reynolds JEF, editor. Martindale: Te complete drug reference. London: Royal Pharmaceutical Society; 1999:2-12.
14. Brogden R, Wiseman L. Aceclofenac: A review of its pharma-codynamic properties and therapeutic potential in the treatment of rheumatic disorders and in pain management. Drug 1996;52(1):113-124.
15. Mutalik S, Naha A, Usha A, Ranjith A, Musmade P, Manoj K, Anju P, Prasanna S. Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of ace-clofenac. Arch Pharm Res 2007;30(2):222-234.
16. Lee J, Lee Y, Kim J, Yoon M, Choi Y. Formulation of microemul-sion systems for transdermal delivery of aceclofenac. Arch Pharm Res 2005;28(9):1097-1102.
17. Dashora K, Saraf S, Saraf S. Efect of processing variables on microparticulate system of aceclofenac. Pak J Pharm Sci 2006;19(1):1-6.
18. Harikarnpakdee S, Lipipun V, Sutanthavibul RG. Spray dried mucoadhesive microspheres: Preparation and transport through nasal cell monolayer. AAPS Pharm Sci Tech 2006;7(1):E1-10.
19. Arica B, Calis S, Atilla P, Durlu NT, Cakar N, Kash S, Hincal AA. In vitro and in vivo studies of ibuprofen-loaded biodegradable alginate beads. J Microencapsul 2005;22(2):153-165.
20. Acikgoz M, Kas HS, Hascelik Z, Milli U, Hincal AA.Chitosan microspheres of diclofenac sodium. II: In vitro and in vivo evaluation. Pharmazie 1995;50:275-277.
21. Calis S, Arica B, Atilla P, Durlu T, Cakar N, Hincal AA. Efect of ibuprofen and ibuprofen incorporated biodegradable algi-nate beads on gastric and duodenal mucosa (a comparative histological study). Controlled Release Society 30th Annual Meeting Proceedings. 19-23 July, 2003. p 495.
22. Chowdhary KPR, Rao YM. Preparation and evaluation of mucoadhesive microcapsules of indomethacin. Saudi Pharm J 2003;11(3):97-103.
23. Filipovic J, Becirevic M, Skalko N, Jalsenjak I. Chitosan micro-spheres of nifedipine and nifedipine-cyclodextrin inclusion complexes. Int J Pharm 1996;135:183-190.
24. Jain SK, Chourasia MK, Jain AK, Jain RK. Development and characterization of mucoadhesive microspheres bearing salb-utamol for nasal delivery. Drug Deliv 2004;11:113-122.
25. Soni T, Nagda C, Gandhi T, Chotai N. Development of discriminating method for dissolution of aceclofenac marketed formulations. Dissol Technol 2008;15(2):31-35.
26. Costa P, Lobo J. Modeling and comparison of dissolution pro-fles. Eur J Pharm Sci 2001;13:123-133.
27. Genta I, Perugini P, Conti B, Pavanetto F. A multiple emulsion method to entrap a lipophilic compound into chitosan micro-spheres. Int J Pharm 1997;152:237-246.
28. Dubey RR, Parikh RH. Two-Stage optimization process for formulation of chitosan microspheres. AAPS PharmSciTech 2004;5(1):1-9.
29. Maia JL, Santana MHA, Re MI. Te efect of some processing conditions on the characteristics of biodegradable micro-spheres obtained by an emulsion solvent evaporation process. Braz J Chem Eng 2004;21(1):1-12.
30. Shanmuganathan S, Shanumugasundaram N, Adhirajan N, Ramyaa Lakshmi TS, Babu M. Preparation and characterization of chitosan microspheres for doxycycline delivery. Carbohyd Polym 2008;73:201-211.
31. Rama Rao K, Senapati P, Das MK. Formulation and in vitro evaluation of ethyl cellulose microspheres containing zidovudine. J Microencapsul 2005;22(8):863-876.
32. Patel JK, Patel MM. Stomach specifc anti-helicobacter pylori therapy: Preparation and evaluation of amoxicillin-loaded chitosan mucoadhesive microspheres. Curr Drug Deliv 2007;4:41-50.
33. Agarwal V, Mishra B. Design, development, and biopharma-ceutical properties of buccoadhesive compacts of pentazocine. Drug Dev Ind Pharm 1999;25:701-709.
34. Hafner A, Filipove-Gri J, Voinovich D, Jalsenjak I. Development and in vitro characterization of chitosan-based microspheres for nasal delivery of promethazine. Drug Dev Ind Pharm 2007;33:427-436.
35. Shantha KL, Bala U, Rao KP. Tailor made chitosans for drug delivery. Eur Polym J 1995;31(4):317-382.
36. BP IV, 17th Ed., London: MHRA; 2007, A288 appendix XII E.
37. Das MK, Maurya PK. Evaluation of diltiazem hydrochloride-loaded mucoadhesive microspheres prepared by emul-sifcation-internal gelation technique. Acta Pol Pharm 2008;65(2):249-259.