Preparation and characterization of chitosan microspheres for doxycycline delivery

Carbohydrate Polymers

Volumn 73, Issue 2, 2008, Pages 201-211

  Shanmuganathan, S ^a,b   Shanumugasundaram, N ^a   Adhirajan, N ^a   Ramyaa Lakshmi, T S ^a   Babu, Mary ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^b SRI RAMACHANDRA UNIVERSITY   (India)

Author keywords

Biocompatibility; Chitosan microspheres; Doxycycline; Fibroblasts; MMP

Indexed keywords

CONCENTRATION (PROCESS); DRUG DELIVERY; ESCHERICHIA COLI; GELATION; MICROSPHERES; SURFACE MORPHOLOGY; SWELLING;

CHITOSAN MICROSPHERES; DOXYCYCLINE; IONIC GELATION;

CHITOSAN;

ESCHERICHIA COLI; GLYCINE MAX; KLEBSIELLA PNEUMONIAE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 41549090837     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2007.11.039     Document Type: Article

References (33)

1. Aoyagi S., Onishi H., and Machida Y. Novel chitosan wound dressing loaded with minocycline for the treatment of severe burn wounds. International Journal of Pharmaceutics 330 (2007) 138-145
2. Azad A.K., Sermsintham N., Chandrkrachang S., and Stevens W.F. Chitosan membrane as a wound-healing dressing: Characterization and clinical application. Journal of Biomedical Materials Research Part B: Applied Biomaterials 69 (2004) 216-222
3. Berthod F., Saintigny G., Chretien F., Hayek D., Collombel C., and Damour O. Optimization of thickness, pore size and mechanical properties of a biomaterial designed for deep burn coverage. Clinical Materials 15 (1994) 259-265
4. Blanco M.D., Gomez C., Olmo R., Muniz E., and Teijon J.M. Chitosan microspheres in PLG films as devices for cytarabine release. International Journal of Pharmaceutics 202 (2000) 29-39
5. Chin G.A., Thigpin T.G., Perrin K.J., Moldawer L.L., and Schultz G.S. Treatment of chronic ulcers in diabetic patients with a topical metalloproteinase inhibitor, doxycycline. Wounds 15 (2003) 315-323
6. Choi D.H., Moon I.S., Choi B.K., Paik W., Kim Y.S., Choi S.H., et al. Effects of sub-antimicrobial dose doxycycline therapy on cervicular fluid MMP-2, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis. Journal of Periodontal Research 39 (2004) 20-26
7. Clavo P., Vila-Jato J.L., and Alonso M.J. Evaluation of cationic polymer coated nanocapsules as ocular drug carriers. Journal of Pharmaceutics 153 (1997) 41-50
8. Fass R.J., and Barnishan J. Minimal inhibitory concentrations of 34 antimicrobial agents for control strains Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. Antimicrobial Agents and Chemotherapy 16 (1979) 622-624
9. Franz T.J. The finite dose technique as a valid in vitro model for the study of percutaneous absorption in man. Current Problems in Dermatology 7 (1978) 58-68
10. Gapski R., Barr J.L., Sarment D.P., Layher M.G., Socransky S.S., and Giannobile W.V. Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: A proof of concept trial. Journal of Periodontology 75 (2004) 441-452
11. Hirano S., Seino H., Akiyama Y., and Nonaka I. Biocompatibility of chitosan by oral and intravenous administrations. Polymeric Materials: Science and Engineering 59 (1988) 897-901
12. Issa M.M., Hoggard P.K., and Arthurson P. Chitosan and the mucosal delivery of biotechnology drugs. Drug Discovery Today: Technologies 2 (2005) 1-6
13. Jameela S.R., and Jayakrishnan A. Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: Studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials 16 (1995) 769-775
14. Janes K.A., Fresneau M.P., Marazuela A., Fabra A., and Alonso M.J. Chitosan nanoparticles as delivery systems for doxorubicin. Journal of Controlled Release 73 (2001) 255-267
15. Khan T.A., and Peh K.K. A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats. Journal of Pharmacy and Pharmaceutical Sciences 6 (2003) 20-26
16. Kumar T.R., Shanmugasundaram N., and Babu M. Biocompatible collagen scaffolds from a human amniotic membrane: Physicochemical and in vitro culture characteristics. Journal of Biomaterials Science, Polymer Edition 14 (2003) 689-706
17. Lim L.Y., and Wan L.S.C. Effect of magnesium stearate on chitosan microspheres pepared by an emulsification - coacervation technique. Journal of Microencapsulation 15 (1998) 319-333
18. Lynn S.F. Tetracycline and doxycycline applications. Primary Care Update for Ob/Gyns 3 (1996) 224-227
19. Madlener M., Parks W.C., and Werner S. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair. Experimental Cell Research 242 (1998) 201-210
20. Manning M.W., Cassis L.A., and Daugherty A. Differential effects of doxycycline, a broad spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. Arteriosclerosis, Thrombosis and Vascular Biology 23 (2003) 483-488
21. Mehta D. British national formulary. Number 34 (1998), British Medical Association and the Royal Pharmaceutical Society of Great Britain, London
22. Mi F.L., Wong T.B., Shyu S.S., and Chang S.F. Chitosan microspheres: Modification of polymeric chem-physical properties of spray-dried microspheres to control the release of antibiotic drug. Journal of Applied Polymer Science 71 (1999) 747-759
23. Mi F.L., Shyu S.S., Wu Y.B., Lee S.T., Shyong J.Y., and Huang R.N. Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing. Biomaterials 22 (2001) 165-173
24. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65 (1983) 55-63
25. Nordstrom D., Lindy O., Lauhio A., Sorsa T., Santavirta S., and Kontttinen Y.T. Anti-collagenolytic mechanism of action of doxyclycline treatment in rheumatoid arthritis. Rheumatology International 17 (1998) 175-180
26. Prasitsilp M., Jenwithisuk R., Kongsuwan K., Damrongchai N., and Watts P. Cellular response to chitosan in vitro: The importance of deacetylation. Journal of Materials Science: Materials in Medicine 11 (2000) 773-778
27. Ryan M.E., Usman A., Ramamurthy N.S., Golub L.M., and Greenwald R.A. Excessive matrix metalloproteinase activity in diabetes: Inhibition by tetracycline analogues with zinc reactivity. Current Medicinal Chemistry 8 (2001) 305-316
28. Shanmugasundaram N., Ravikumar T., and Babu M. Comparative physico-chemical and in vitro properties of fibrillated scaffolds from different sources. Journal of Biomaterials Application 18 (2004) 247-264
29. Shanmugasundaram N., Sundaraseelan J., Uma S., Selvaraj D., and Babu M. Design and delivery of silver sulfadiazine from alginate microspheres-impregnated collagen scaffold. Journal of Biomedical Materials Research Part B: Applied Biomaterials 77B (2006) 378-388
30. Shu X.Z., and Zhu K.J. Controlled drug release properties of ionically crosslinked chitosan beads: The influence of anion structure. International Journal of Pharmaceutics 233 (2002) 217-225
31. Siemonsma M.A., De Hingh I.H.J.T., De Man B.M., Lomme R.M.L.M., Verhofstad A.A.J., and Hendriks T. Doxycycline improves wound strength after intestinal anastomosis in the rat. Surgery 133 (2003) 268-276
32. Tahnoo B.C., Sunny M.C., and Jayakrishnan A. Crosslinked chitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals. Journal of Pharmacy and Pharmacology 44 (1992) 283-286
33. Vachon D.J., and Yager D.R. Novel sulfonated hydrogel composite with the ability to inhibit proteases and bacterial growth. Journal of Biomedical Materials Research 76A (2006) 35-43