Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide

Biochemical Journal

Volumn 385, Issue 1, 2005, Pages 135-143

  Andrä, Jörg ^a   Lohner, Karl ^b   Blondelle, Sylvie E ^c   Jerala, Roman ^d   Moriyon, Ignacio ^e   Koch, Michel H J ^f   Garidel, Patrick ^g   Brandenburg, Klaus ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^e UNIVERSITY OF NAVARRA   (Spain)

^f EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^g MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Antimicrobial peptide; Antisepsis; Endotoxin; Hydrophobic extension; Lactoferricin; Lipopolysaccharide (LPS)

Indexed keywords

ACYLATION; CELLS; CHEMICAL MODIFICATION; CHOLESTEROL; GELS; HYDROPHOBICITY; LIPIDS; LIQUID CRYSTALS; PHASE TRANSITIONS; POLYPEPTIDES; POLYSACCHARIDES;

BIOLOGICAL ACTIVITIES; ENDOTOXIN; ENDOTOXIN NEUTRALIZATION; MONONUCLEAR CELLS; PEPTIDE BINDING;

BACTERIA;

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; LACTOFERRICIN; LIPID A; PEPTIDE DERIVATIVE;

ACYLATION; ANTISEPSIS; ARTICLE; CYTOTOXICITY; HELA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFRARED SPECTROSCOPY; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN MODIFICATION; SALMONELLA ENTERICA; X RAY DIFFRACTION; ZETA POTENTIAL;

ALKYLATION; AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; CALCIUM; CALORIMETRY, DIFFERENTIAL SCANNING; CATIONS; CELLS, CULTURED; ELECTROSTATICS; ENDOTOXINS; ERYTHROCYTES; HEMOLYSIS; HUMANS; LACTOFERRIN; LEUKOCYTES, MONONUCLEAR; MELITTEN; PEPTIDES; SALMONELLA ENTERICA; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TEMPERATURE; THERMODYNAMICS; X-RAY DIFFRACTION;

BACTERIA (MICROORGANISMS); SALMONELLA; SALMONELLA ENTERICA;

EID: 12744263109     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041270     Document Type: Article

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