Downregulation of RhoA and changes in T cell cytoskeleton correlate with the abrogation of allograft rejection

Transplant Immunology

Volumn 23, Issue 4, 2010, Pages 185-193

  Skelton, T Spencer ^a   Tejpal, Neelam ^a   Gong, Yongquan ^a   Kloc, Malgorzata ^a   Ghobrial, Rafik M ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

Author keywords

Actin; Hip55; RhoA; T cell

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; CHIMERIC PROTEIN; CYCLOSPORIN A; CYTOSKELETON PROTEIN; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN HIP55; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; DRUG MECHANISM; ENZYME REGULATION; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART GRAFT; LYMPHOCYTE FUNCTION; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ACTINS; ANIMALS; CELLS, CULTURED; CYTOSKELETON; DOWN-REGULATION; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; MICROFILAMENT PROTEINS; PROTEIN TRANSPORT; RATS; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; RHOA GTP-BINDING PROTEIN; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES;

EID: 77956064074     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2010.06.009     Document Type: Article

References (32)

1. Burkhardt J.K., Carrizosa E., Shaffer M.H. The actin cytoskeleton in T cell activation. Annu Rev Immunol 2008, 26:233-259.
2. Al-Alwan M.M., Liwski R.S., Haeryfar S.M.M., Baldridge W.H., Hoskin D.W., Rowden G., West K.A. Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J Immunol 2003, 171:4479-4483.
3. Brossard C., Feuillet V., Schmitt A., Randriamampita C., Romao M., Raposo G., Trautmann A. Multifocal structure of the T cell-dendritic cell synapse. Eur J Immunol 2005, 35:1741-1753.
4. Davis D.M., Dustin M.L. What is the importance of the immunological synapse?. Trends Immunol 2004, 25:323-327.
5. Dustin M.L. Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses. Curr Opin Cell Biol 2007, 19:529-533.
6. Dustin M.L. Synaptic asymmetry to go. Cell 2008, 132:733-734.
7. Dustin M.L., Cooper J.A. The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat. Immunol. 2000, 1:23-29.
8. Huang Y., Burkhardt J.K. T-cell-receptor-dependent actin regulatory mechanisms. J Cell Sci 2007, 120:723-730.
9. Sancho D., Vicente-Manzanares M., Mittelbrunn M., Montoya M.C., Gordon-Alonso M., Sarrador J.M., Sanchez-Madrid F. Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions. Immunol Rev 2002, 189:84-97.
10. Vicente-Manzanares M., Sánchez-Madrid F. Role of the cytoskeleton during leukocyte responses. Nat Rev Immunol 2004, 4:110-122.
11. Le Bras S., Foucault I., Foussat A., Brignone C., Acuto O., Deckert M. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. J Biol Chem 2004, 279:15550-15560.
12. Han J., Shui W., Zhang X., Zheng B., Han S., Tan T.-H. HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Mol Cell Biol 2005, 25:6869-6878.
13. Xu Y., Li J., Ferguson G.D., Mercurio F., Khambatta G., Morrison L., Lopez-Girona A., Corral L.G., Webb D.R., Bennett B.L., Xie W. Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases. Blood 2009, 114:338-345.
14. Pernis A.B. Rho GTPase-mediated pathways in mature CD4+ T cells. Autoimmun Rev 2009, 8:199-203.
15. Lee J.H., Katakai T., Hara T., Gonda H., Sugai M., Shimizu A. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol 2004, 167:327-337.
16. Nijhara R., van Hennik P.B., Gignac M.L., Kruhlak M.J., Hordijk P.L., Delon J., Shaw S. Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytes. J Immunol 2004, 173:4985-4993.
17. Tharaux P.L., Bukoski R.C., Rocha P.N., Crowley S.D., Ruiz P., Nataraj C., Howell D.N., Kaibuchi K., Spurney R.F., Coffman T.M. Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. J Immunol 2003, 171:96-105.
18. Corre I., Gomez M., Vielkind S., Cantrell D.A. Analysis of thymocyte development reveals that the GTPase RhoA is a positive regulator of T cell receptor responses in vivo. J Exp Med 2001, 194:903-913.
19. Vicente-Manzanares M., Rey M., Pérez-Martínez M., Yáñez-Mó M., Sancho D., Cabrero J.R., Barreiro O., de la Fuente H., Itoh K., Sánchez-Madrid F. The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes. J Immunol 2003, 171:1023-1034.
20. Delaguillaumie A., Lagaudrière-Gesbert C., Popoff M.R., Conjeaud H. Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes. J Cell Sci 2002, 115:433-443.
21. Dunn D.L. Problems related to immunosuppression. Infection and malignancy occurring after solid organ transplantation. Crit Care Clin 1990, 6:955-977.
22. Trivedi H.L. Immunobiology of rejection and adaptation. Trans. Proc. 2007, 39:647-652.
23. Butcher G.W., Howard J.C. Genetic control of transplant rejection. Transplantation 1982, 34:161-166.
24. Colovai A.I., Renna-Molajoni E., Cortesini R., Suciu-Foca N. New approaches to specific immunomodulation in transplantation. Int Rev Immunol 1996, 13:161-172.
25. Ghobrial R.M., Hamashima T., Wang M., Stepkowski S.M., Kahan B.D. Induction of transplantation tolerance by chimeric donor/recipient class I RT1.Aa molecules. Transplantation 1996, 62:1002-1010.
26. Semiletova N., Shen X.D., Fishbein M.C., Gao F., Slomowitz S.J., Jiao Q., et al. Posttransplant administration of allochimeric major histocompatibility complex class-I-molecules induces true transplantation tolerance. Transplantation 2003, 75:550-553.
27. Semiletova N.V., Shen X.D., Baibakov B., Feldman D.M., Mukherjee K., Frank J.M., et al. Inhibition of chronic rejection by antibody induced vascular accommodation in fully allogeneic heart allografts. Transplantation 2005, 80:1535-40.
28. Singer J.S., Mhoyan A., Fishbein M.C., Shen X.D., Gao F., Zhao D., et al. Allochimeric class I MHC molecules prevent chronic rejection and attenuate alloantibody responses. Transplantation 2001, 72:1408-1416.
29. Liu D., Shen X.D., Zhai Y., Lam W., Liao J., Busuttil R.W., Ghobrial R.M. Intragraft selection of the T cell receptor repertoire by class I MHC sequences in tolerant recipients. PLoS ONE 2009, 4:e6076.
30. Lisik W., Tejpal N., Gong Y., Skelton T.S., Ganachari M., Bremer E.G., Kloc M., Ghobrial R.M. Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I. PLoS ONE 2009, 4:e8020.
31. Kloc M., Reddy B., Crawford S., Etkin L.D. A Novel 110-kDa maternal CAAX box-containing protein from Xenopus is palmitoylated and isoprenylated when expressed in baculovirus. J Biol Chem 1991, 266:8206-8212.
32. Wheelera A.P., Ridley A.J. Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 2004, 301:43-49.