Triphenyltin(IV) 2-[(E)-2-(aryl)-1-diazenyl]benzoates as anticancer drugs: Synthesis, structural characterization, in vitro cytotoxicity and study of its influence towards the mechanistic role of some key enzymes

Investigational New Drugs

Volumn 28, Issue 5, 2010, Pages 587-599

  Basu Baul, Tushar S ^a   Paul, Anup ^a   Pellerito, Lorenzo ^b   Scopelliti, Michelangelo ^b   Singh, Palwinder ^c   Verma, Pooja ^c   De Vos, Dick ^d  

^a NORTH EASTERN HILL UNIVERSITY   (India)

^b UNIVERSITY OF PALERMO   (Italy)

^c GURU NANAK DEV UNIVERSITY   (India)

^d TEVA Pharmachemie   (Netherlands)

Author keywords

Anti cancer drugs; Cell lines; Docking studies; Triphenyltin(IV) 2 (E) 2 (3 formyl 4 hydroxyphenyl) 1 diazenyl benzoate; Triphenyltin(IV) 2 (E) 2 (4 Hydroxy 5 methylphenyl) 1 diazenyl benzoate; Triphenyltin(IV) benzoates

Indexed keywords

CISPLATIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; FLUOROURACIL; METHOTREXATE; PACLITAXEL; PHOSPHORYLASE; RIBONUCLEOTIDE REDUCTASE; THYMIDYLATE PHOSPHORYLASE; THYMIDYLATE SYNTHASE; TIN DERIVATIVE; TRIPHENYLTIN 2 [2 (3 FORMYL 4 HYDROXYPHENYL) 1 DIAZENYL]BENZOATE; TRIPHENYLTIN 2 [2 (4 HYDROXY 5 METHYLPHENYL) 1 DIAZENYL]BENZOATE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; ORGANOTIN COMPOUND; TRIPHENYLTIN;

ARTICLE; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ID 50; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; QUANTUM MECHANICS; TOXICOLOGICAL PARAMETERS; BINDING SITE; CELL DEATH; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; INFRARED SPECTROPHOTOMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUANTUM THEORY; SYNTHESIS; THERMODYNAMICS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL DEATH; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; ORGANOTIN COMPOUNDS; QUANTUM THEORY; RIBONUCLEOTIDE REDUCTASES; SPECTROPHOTOMETRY, INFRARED; THERMODYNAMICS; THYMIDYLATE SYNTHASE;

EID: 77956059024     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9293-x     Document Type: Article

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