Toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of di- and triorganotin compounds

Metal-Based Drugs

Volumn 5, Issue 2, 1998, Pages 83-90

  Gielen, M ^a   Willem, R ^a   Dalil, H ^a   De Vos, D ^b   Kuiper, C M ^c   Peters, G J ^c  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b TEVA Pharmachemie   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYCHOLIC ACID; DIBUTYLTIN; ORGANOTIN COMPOUND; TRIBUTYLTIN;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; INTRAPERITONEAL DRUG ADMINISTRATION; MAXIMUM PERMISSIBLE DOSE; MOUSE; NONHUMAN;

EID: 0031747019     PISSN: 07930291     EISSN: None     Source Type: Journal    
DOI: 10.1155/MBD.1998.83     Document Type: Article

References (16)

1. Bouâlam M, Gielen M, Meriem A, de Vos D, Willem R, Pharmachemie B.V., Eur. Pat. Publ. 472 783, Appl. 90/202,316.7, 21/09/90, Anti-tumor compositions and compounds, Chem. Abstr. (1992) 116: 235 873q
2. Boualam M, Gielen M, El Khloufi A, de Vos, D., Willem, R., Pharmachemie B.V., Eur. Pat. Publ. 538 517, Appl. 91/202,746.-, 22.10.91, Novel organo-tin compounds having anti-tumour activity and anti-tumour compositions, Chem. Abstr. (1993) 119: 117 548b
3. Corbett TH, Griswold DP, Roberts BJ, Peckham JC, Schabel FM. Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas. Cancer (1975) 40: 2660-2680
4. Gielen M, Pan H, Willem R, de Vos D, Pharmachemie B.V., Eur. Pat. Publ. 484 596, Appl. 90/202,936.2, 06/11/90, Antitumour compositions and compounds, Chem. Abstr. (1992)117, 111 807x
5. Gielen M, Willem R, Bouhdid A, de Vos D, Kuiper CM, Veerman G, Peters GJ, In vitro antiproliferative effects, toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of five organotin compounds, In vivo (1995) 9: 59-64
6. Gielen M, Willem R, Bouhdid A, de Vos D, Pharmachemie B.V., Eur. Pat. Publ. 677 528 A1, Appl. 94/201012.5, 12/04/94, Dibutyltin bis(hydroxybenzoates) and compositions containing these compounds, Chem. Abstr. (1996a) 124: 87 376c
7. Gielen M, Willem R, Bouhdid A, de Vos D, Pharmachemie B.V., Eur. Pat. Publ. 700 921, Appl. 94/202,612.1, 09/09/94, Aromatic fluorine-containing organotin compounds and anti-tumour compositions, Chem. Abstr. (1996b) 124: 343 674z
8. Gielen M, Tin-based antitumour drugs, Coord. Chem. Rev. (1996c) 151: 41-51
9. Gielen M, Willem R, Bouhdid A, de Vos D, Kuiper CM, Veerman G, Peters GJ, In vitro antiproliferative effects, toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of four diorganotin compounds, Oncol. Rep. (1996d) 3: 583-587
10. Gielen, M, Ma H, Bouhdid A, Dalil H, Biesemans M, Willem R, Di-n-butyl-, tri-n-butyl- and triphenyltin dl-terebates: synthesis, characterization and in vitro antitumour activity, Metal-Based Drugs (1997) 4: 193-197
11. Peters GJ, Van Dijk J, Nadal J, Van Groeningen CJ, Lankelma J, Pinedo HM. Diurnal variation in the therapeutic efficacy of 5-fluorouracil against murine colon cancer. In Vivo (1987) 1: 113-118
12. Peters GJ, Braakhuis BJM, De Bruijn EA, Laurensse EJ, Van Walsum M, Pinedo HM. Enhanced therapeutic efficacy of 5′-deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolizing enzymes, Brit. J. Cancer (1989) 59: 327-334
13. Van der Wilt CL, Smid K, Pinedo HM, Peters GJ. Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by addition of leucovorin in murine colon tumors, Cancer Res. (1992a) 52: 4922-4928
14. Van Laar JAM, Rustum YM, Van der Wilt C, Smid K, Kuiper CM, Pinedo HM, Peters GJ. Tumor size and origin determine the antitumor activity of cisplatin or 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas, Cancer Chemother. Pharmacol. (1996) 39: 79-89
15. Willem R, Dalil H, Broekaert P, Biesemans M, Ghys L, Nooter K, de Vos D, Ribot F, Gielen M, Di-n-butyl-, tri-n-butyl- and triphenyltin steroidcarboxylates: synthesis, NMR characterization and in vitro antitumour activity, Main Group Met. Chem. (1997a) 20: 535-542
16. Willem R, Bouhdid A, Mahieu B, Ghys L, Biesemans M, Tiekink ERT, de Vos D, Gielen M, Synthesis, characterization and in vitro antitumour activity of triphenyl- and tri-n-butyltin benzoates, phenylacetates and cinnamates, J. Organomet. Chem. (1997b) 531: 151-158