Period 2 gene deletion abolishes β-endorphin neuronal response to ethanol

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 9, 2010, Pages 1613-1618

  Agapito, Maria ^a   Mian, Nadia ^a   Boyadjieva, Nadka I ^a   Sarkar, Dipak K ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Central Nervous System; Clock Gene; Endogenous Opioid; Ethanol; Stress Axis

Indexed keywords

ALCOHOL; BETA ENDORPHIN;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHRONICITY; CIRCADIAN RHYTHM; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE DELETION; GENE MUTATION; HYPOTHALAMUS; LONG TERM EXPOSURE; MALE; MILK; MOUSE; NONHUMAN; PER2 GENE; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BETA-ENDORPHIN; CELLS, CULTURED; ETHANOL; FEMALE; GENE DELETION; HYPOTHALAMUS; MALE; MICE; MICE, INBRED C57BL; NEURONS; PERIOD CIRCADIAN PROTEINS;

ANIMALIA; MUS; RODENTIA;

EID: 77956047018     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01246.x     Document Type: Article

References (51)

1. Alvarez M, Pita S, Costas E, Cupeiro A, Chaves OF, García M, Sola A, Goyanes V (1995) Long term effects of ritodrine on blood pressure and heart rate of adolescents exposed during the prenatal stage. Eur J Obstet Gynecol Reprod Biol 59 : 137 141.
2. Arjona A, Boyadjieva N, Kuhn P, Sarkar DK (2006a) Fetal ethanol exposure disrupts the daily rhythms of splenic granzyme B, IFN-gamma, and NK cell cytotoxicity in adulthood. Alcohol Clin Exp Res 30 : 1039 1044.
3. Arjona A, Boyadjieva N, Sarkar DK (2004) Circadian rhythms of granzyme B, perforin, IFN-gamma, and NK cell cytolytic activity in the spleen: effects of chronic ethanol. J Immunol 172 : 2811 2817.
4. Arjona A, Sarkar DK (2006b) The circadian gene mPer2 regulates the daily rhythm of IFN-γ. J Interferon Cytokine Res 26 : 645 649.
5. Blizard DA, Vandenbergh DJ, Jefferson AL, Chatlos CD, Vogler GP, McClearn GE (2004) Effects of periadolescent ethanol exposure on alcohol preference in two BALB substrains. Alcohol 34 : 177 185.
6. Boyadjieva NI, Chen CP, Sarkar DK (2003) Role of nitric oxide in alcohol alteration of β-endorphin release from hypothalamic cells in primary cultures. Alcohol Clin Exp Res 27 : 1813 1818.
7. Boyadjieva N, Meadows GG, Sarkar DK (2001) Chronic ethanol inhibits natural killer cell cytolytic activity: role of opioid peptide beta-endorphin. J Immunol 167 : 5645 5652.
8. Boyadjieva NI, Ortigüela M, Arjona A, Cheng X, Sarkar DK (2009) ß-endorphin neuronal cell transplant reduces corticotropin releasing hormone hyperresponse to lipopolysaccharide and eliminates natural killer cell functional deficiencies in fetal alcohol exposed rats. Alcohol Clin Exp Res 33 : 931 937.
9. Boyadjieva NI, Sarkar DK (1994) Effects of chronic alcohol on immunoreactive β-endorphin secretion from hypothalamic neurons in primary cultures: evidence for alcohol tolerance, withdrawal, and sensitization responses. Alcohol Clin Exp Res 18 : 1497 1501.
10. Boyadjieva N, Sarkar DK (1997) The role of cAMP in ethanol-regulated beta-endorphin release from hypothalamic neurons. Alcohol Clin Exp Res 21 : 728 731.
11. Brown RE (1998) An Introduction to Neuroendocrinology. Cambridge University Press, New York, NY, pp 41 43.
12. Chen CP, Kuhn P, Advis JP, Sarkar DK (2004) Chronic ethanol consumption impairs the circadian rhythm of proopiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. J Neurochem 88 : 1547 1554.
13. Chen CP, Kuhn P, Advis JP, Sarkar DK (2006) Prenatal ethanol exposure alters the expression of period genes governing the circadian function of ß-endorphin. J Neurochem 97 : 1026 1033.
14. Chotro MG, Arias C (2003) Prenatal exposure to ethanol increases ethanol consumption: a conditioned response? Alcohol 30 : 19 28.
15. Church AC, Feller D (1979) The influence of mouse genotype on the changes in brain cyclic nucleotide levels induced by acute alcohol administration. Pharmacol Biochem Behav 10 : 335 338.
16. De Wied D, Jolles J (1982) Neuropeptides derived from pro-opiocortin: behavioral, physiological, and neurochemical effects. Physiol Rev 62 : 976 1059.
17. Devaney M, Graham D, Greeley J (2003) Circadian variation of the acute and delayed response to alcohol: investigation of core body temperature variations in humans. Pharmacol Biochem Behav 75 (4 881 887.
18. Farnell YZ, Allen GC, Nahm SS, Neuendorff N, West JR, Chen WJ, Earnest DJ (2008) Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats. Alcohol Clin Exp Res 32 : 544 552.
19. Gianoulakis C (1996) Implications of endogenous opioids and dopamine in alcoholism: human and basic science studies. Alcohol Alcohol 31 : 33 42.
20. Goodlett CR, Pearlman AD, Lundahl KR, (1998) Binge neonatal alcohol intubations induce dose-dependent loss of Purkinje cells. Neurotoxicol Teratol 20 : 285 292.
21. Handa RJ, Zuloaga DG, McGivern RF (2007) Prenatal ethanol exposure alters core body temperature and corticosterone rhythms in adult male rats. Alcohol 41 : 567 575.
22. Hilakivi-Clarke L, Cabanes A, de Assis S, Wang M, Khan G, Shoemaker WJ, Stevens RG (2004) In utero alcohol exposure increases mammary tumorigenesis in rats. Br J Cancer 90 : 2225 2231.
23. Jin X, Shearman LP, Weaver DR, Zylka MJ, de Vries GJ, Reppert SM (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell 96 : 57 68.
24. Ko CH, Takahashi JS (2006) Molecular components of the mammalian circadian clock. Hum Mol Genet 15 : R271 277.
25. Konturek PC, Konturek JW, Cześnikiewicz-Guzik M, Brzozowski T, Sito E, Konturek SJ (2005) Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol 56 (Suppl 6 5 25.
26. Lee CC (2006) Tumor suppression by the mammalian period genes. Cancer Causes Control 17 : 525 530.
27. Middaugh LD, Kelley BM, Bandy AL, McGroarty KK (1999) Ethanol consumption by C57BL/6 mice: influence of gender and procedural variables. Alcohol 17 : 175 183.
28. Nakashita M, Ohkubo T, Hara A, Metoki H, Kikuya M, Hirose T, Tsubota-Utsugi M, Asayama K, Inoue R, Kanno A, Obara T, Hoshi H, Totsune K, Satoh H, Imai Y (2009) Influence of alcohol intake on circadian blood pressure variation in Japanese men: the Ohasama study. Am J Hypertens 22 (11 1171 1176.
29. Ohkubo T, Metoki H, Imai Y (2009) Alcohol intake, circadian blood pressure variation, and stroke. Hypertension 53 : 4 5.
30. Pastor R, Aragon CM (2008) Ethanol injected into the hypothalamic arcuate nucleus induces behavioral stimulation in rats: an effect prevented by catalase inhibition and naltrexone. Behav Pharmacol 19 : 698 705.
31. Pastorcic M, Boyadjieva N, Sarkar DK (1994) Comparison of the effects of alcohol and acetaldehyde on proopiomelanocortin mRNA expression and beta-endorphin secretion from hypothalamic neurons in primary cultures. Mol Cell Neurosci 5 : 580 586.
32. Poplawski M, Boyadjieva N, Sarkar DK (2005) Vasoactive intestinal peptide and corticotropin-releasing hormone increase β-endorphin release and POMC mRNA levels in primary cultures of hypothalamic cells: effects of acute and chronic ethanol. Alcohol Clin Exp Res 29 : 648 655.
33. Rasmussen DD, Boldt BM, Bryant CA, Mitton DR, Larsen SA, Wilkinson CW (2000) Chronic daily ethanol and withdrawal: 1. Long-term changes in the hypothalamo-pituitary-adrenal axis. Alcohol Clin Exp Res 24 : 1836 1849.
34. Rasmussen DD, Bryant CA, Boldt BM, Colasurdo EA, Levin N, Wilkinson CW (1998) Acute alcohol effects on opiomelanocortinergic regulation. Alcohol Clin Exp Res 22 : 789 801.
35. Raymond RC, Warren M, Morris RW, Leikin JB (1992) Periodicity of presentations of drugs of abuse and overdose in an emergency department. J Toxicol Clin Toxicol 30 : 467 478.
36. Reddy BV, Boyadjieva N, Sarkar DK (1995) Effect of ethanol, proponol, butanol and catalase enzyme blockers on beta-endorphin secretion from primary cultures of hypothalamic neurons: evidence for a mediatory role of acetaldehyde in ethanol stimulation of beta-endorphin release. Alcohol Clin Exp Res 19 : 339 344.
37. Röjdmark S, Calissendorff J, Brismar K (2001) Alcohol ingestion decreases both diurnal and nocturnal secretion of leptin in healthy individuals. Clin Endocrinol (Oxf) 55 : 639 647.
38. Ruby CL, Brager AJ, DePaul MA, Prosser RA, Glass JD (2009) Chronic ethanol attenuates circadian photic phase resetting and alters nocturnal activity patterns in the hamster. Am J Physiol Regul Integr Comp Physiol 297 : R729 R737.
39. Sakata-Haga H, Dominguez HD, Sei H, Fukui Y, Riley EP, Thomas JD (2006) Alterations in circadian rhythm phase shifting ability in rats following ethanol exposure during the third trimester brain growth spurt. Alcohol Clin Exp Res 30 : 899 907.
40. Sarkar DK, Boyadjieva NI, Chen CP, Ortigüela M, Reuhl K, Clement KM, Kuhn P, Marano J (2008) Cyclic adenosine monophosphate differentiated beta-endorphin neurons promote immune function and prevent prostate cancer growth. Proc Natl Acad Sci USA 105 : 9105 9110.
41. Sarkar DK, Kuhn P, Marano J, Chen C, Boyadjieva N (2007) Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function. Endocrinology 148 : 2828 2834.
42. Sarkar DK, Minami S (1990) Effect of acute ethanol on beta-endorphin secretion from rat fetal hypothalamic neurons in primary cultures. Life Sci 47 : PL31 36.
43. Schwartz WJ, Zimmerman P (1990) Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains. J. Neurosci 10 : 3685 3694.
44. Seggio JA, Fixaris MC, Reed JD, Logan RW, Rosenwasser AM (2009) Chronic ethanol intake alters circadian phase shifting and free-running period in mice. J Biol Rhythms 24 : 304 312.
45. Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U (2005a) The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 11 : 35 42.
46. Spanagel R, Rosenwasser AM, Schumann G, Sarkar DK (2005b) Alcohol consumption and the body's biological clock. Alcohol Clin Exp Res 29 : 1550 1557.
47. Taylor AN, Branch BJ, Cooley-Matthews B, Poland RE (1982) Effects of maternal ethanol consumption in rats on basal and rhythmic pituitary-adrenal function in neonatal offspring. Psychoneuroendocrinology 7 : 49 58.
48. Therrien M, Drouin J (1993) Molecular determinants for cell specificity and glucocorticoid repression of the proopiomelanocortin gene. Ann N Y Acad Sci 31 : 680.
49. Weinberg J, Sliwowska JH, Lan N, Hellemans KG (2008) Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome. J Neuroendocrinol 20 : 470 488.
50. Zghoul T, Abarca C, Sanchis-Segura C, Albrecht U, Schumann G, Spanagel R (2007) Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice. Psychopharmacology (Berl) 190 : 13 19.
51. Zheng B, Larkin D, Albrecht U, Sun ZS, Sage M, Eichele G, Lee CC, Bradley A (1999) The mPer2 gene encodes a functional component of the mammalian clock. Nature 400 : 169 173.