Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1

Toxicological Sciences

Volumn 99, Issue 1, 2007, Pages 51-57

  Kushman, Mary E ^a   Kabler, Sandra L ^a   Ahmad, Sarfaraz ^a   Doehmer, Johannes ^b   Morrow, Charles S ^a   Townsend, Alan J ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b Gen Pharm Tox   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; CYTOCHROME P450 1A1; GLUTATHIONE TRANSFERASE M1;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL LINE; CELL MEDIATED CYTOTOXICITY; CELL PROTECTION; CHEMICAL MUTAGENESIS; CHINESE HAMSTER; CONTROLLED STUDY; DETOXIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENOTOXICITY; MUTAGENICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; BENZO(A)PYRENE; CELL LINE; CRICETINAE; CRICETULUS; CYTOCHROME P-450 CYP1A1; DIHYDROXYDIHYDROBENZOPYRENES; DNA; DNA ADDUCTS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE TRANSFERASE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; METABOLIC DETOXICATION, DRUG; MUTAGENICITY TESTS; MUTAGENS; MUTATION; STEREOISOMERISM; TRANSFECTION;

EID: 34547902440     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm133     Document Type: Article

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