Expression of human glutathione transferases in V79 cells and the effect on DNA adduct-formation of diol epoxides derived from polycyclic aromatic hydrocarbons

Chemico-Biological Interactions

Volumn 133, Issue 1-3, 2001, Pages 95-97

  Sundberg, Kathrin ^a   Dreij, Kristian ^a   Berntsen, Sofia ^a   Seidel, Albrecht ^b   Jernström, Bengt ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Prof Dr Gernot Grimmer Foundation   (Germany)

Author keywords

Conjugation; Diol epoxides; DNA adducts; Human GSTP1 1

Indexed keywords

EID: 0039893835     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. A.J. Townsend, W.R. Fields, R.L. Haynes, A.J. Doss, Y. Li, J. Doehmer, C.S. Morrow, Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection, Chem. Biol. Interact. 111-112 (1998) 389-407.
2. W.R. Fields, C.S. Morrow, A.J. Doss, K. Sundberg, B. Jernström, A.J. Townsend, Overexpression of stably transfected human glutathione S-transferase P1-1 protects against DNA damage by benzo[a]pyrene diol-epoxide in human T47D cells, Mol. Pharmacol. 54 (1998) 298-304.
3. I.G. Robertson, C. Guthenberg, B. Mannervik, B. Jernström, Differences in stereoselectivity and catalytic efficiency of three human glutathione transferases in the conjugation of glutathione with 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene, Cancer. Res. 46 (1986) 2220-2224.
4. C.J. Henderson, A.G. Smith, J. Ure, K. Brown, E.J. Bacon, C.R. Wolf, Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases, Proc. Natl. Acad. Sci. USA 95 (1998) 5275-5280.
5. X. Hu, C. Herzog, P. Zimniak, S.V. Singh, Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of pi class human glutathione S-transferase, Cancer Res. 59 (1999) 2358-2362.
6. F. Ali-Osman, O. Akande, G. Antoun, J.X. Mao, J. Buolamwini, Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins, J. Biol. Chem. 272 (1997) 10004-10012.
7. L.W. Harries, M.J. Stubbins, D. Forman, G.C. Howard, C.R. Wolf, Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer, Carcinogenesis 18 (1997) 641-644.
8. M.A. Watson, R.K. Stewart, G.B. Smith, T.E. Massey, D.A. Bell, Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution, Carcinogenesis 19 (1998) 275-280.
9. D. Ryberg, et al., Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk, Carcinogenesis 18 (1997) 1285-1289.
10. K. Sundberg, A. Seidel, B. Mannervik, B. Jernström, Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione, FEBS Lett. 438 (1998) 206-210.
11. K. Sundberg, A.S. Johansson, G. Stenberg, M. Widersten, A. Seidel, B. Mannervik, B. Jernström, Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons, Carcinogenesis 19 (1998) 433-436.
12. X. Hu, H. Xia, S.K. Srivastava, A. Pal, Y.C. Awasthi, P. Zimniak, S.V. Singh, Catalytic efficiencies of allelic variants of human glutathione S-transferase P1-1 toward carcinogenic anti-diol epoxides of benzo[c]phenanthrene and benzo[g]chrysene, Cancer Res. 58 (1998) 5340-5343.
13. R.O. Rahn, S.S. Chang, J.M. Holland, L.R. Shugart, A fluorometric-HPLC assay for quantitating the binding of benzo[a]pyrene metabolites to DNA, Biochem. Biophys. Res. Commun. 109 (1982) 262-268.
14. K. Sundberg, M. Widersten, A. Seidel, B. Mannervik, B. Jernström, Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1, Chem. Res. Toxicol. 10 (1997) 1221-1227.