Synthesis, biological evaluation, and structure-activity relationship study of novel cytotoxic aza-caffeic acid derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6351-6359

  Zou, Hongbin ^a   Wu, Hao ^a   Zhang, Xiangnan ^a   Zhao, Yu ^a   Stöckigt, Joachim ^a,b   Lou, Yijia ^a   Yu, Yongping ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Aza caffeic acid derivatives; Cytotoxicity; Linker B; Mitochondria dependent apoptosis; SAR analysis

Indexed keywords

(2) 3 (3 METHOXYMETHOXY 4 PHENYLMETHOXY) 2 OXO 2 (2 THIAZOLYLAMINO) 2 PROPEN OIC ACID ETHYL ESTER; (2) 3 (3 METHOXYMETHOXY 4 PHENYLMETHOXY) 2 OXO 2 [(2 FURANYLMETHYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3 METHOXYMETHOXY 4 PHENYLMETHOXY) 2 OXO 2 [(4 CHLOROPHENYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3 METHOXYMETHOXY 4 PHENYLMETHOXY) 2 OXO 2 [(4 METHOXYPHENYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3 METHOXYMETHOXY 4 PHENYLMETHOXY) 2 OXO 2 [(4 MORPHOLINYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3,4 DIHYDROXY) N [2 (1H INDOL 3 YL)ETHYL] 2 PROPENAMIDE; (2) 3 (3,4 DIHYDROXY) N [2 (4 MORPHOLINYL)ETHYL] 2 PROPENAMIDE; (2) 3 (3,4 DIMETHOXYMETHOXY) N [2 (1H INDOL 3 YL) ETHYL] 2 PROPENAMIDE; (2) 3 (3,4 DIMETHOXYMETHOXY) N [2 (4 MORPHOLINYL)ETHYL] 2 PROPENAMIDE; (2) 3 (3,4 DIMETHOXYPHENYL) 2 OXO 2 (4 CHLOROPHENYLAMINO) 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3,4 DIMETHOXYPHENYL) 2 OXO 2 (PHENYLAMINO) 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3,4 DIMETHOXYPHENYL) 2 OXO 2 [(2 FURANYLMETHYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 (3,4 DIMETHOXYPHENYL) N [2 (1H INDOL 3 YL)ETHYL] 2 PROPENAMIDE; (2) 3 (3,4 DIMETHOXYPHENYL) N [2 (4 MORPHOLINYL) ETHYL] 2 PROPENAMIDE; (2) 3 [3,5 DIMETHOXY 4 (3,4 DICHLOROPHENYLMETHOXY)] 2 OXO 2 [(4 CHOLORPHENYL) AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 [3,5 DIMETHOXY 4 (3,4 DICHLOROPHENYLMETHOXY)] 2 OXO 2 [(4 METHOXY PHENYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 [3,5 DIMETHOXY 4 (4 ETHOXYPHENYLMETHOXY)] 2 OXO 2 (PHENYLAMINO) 2 PROPENOIC ACID ETHYL ESTER; (2) 3 [3,5 DIMETHOXY 4 (4 ETHOXYPHENYLMETHOXY)] 2 OXO 2 [(4 CHOLORPHENYL) AMINO] 2 PROPENOIC ACID ETHYL ESTER; (2) 3 [3,5 DIMETHOXY 4 (4 ETHOXYPHENYLMETHOXY)] N [2 (4 MORPHOLINYL)ETHYL] 2 PROPENAMIDE; (2) 3 [3,5 DIMETHOXY 4 (PHENYLMETHOXY)] 2 OXO 2 [(4 METHOXYPHENYL)AMINO] 2 PROPENOIC ACID ETHYL ESTER; 1 (4 (3,4 DICHLOROBENZYL)PIPERAZIN 1 YL) 3 (4 (4 ETHOXYBENZYLOXY) 3,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 4 (3,4 DICHLOROPHENYL METHYL) 1 [3 (3,4 DIMETHOXYMETHOXYPHENYL) 1 OXO 2 PROPENYL]PIPERAZINE; 4 (3,4 DICHLOROPHENYLMETHYL) 1 [1 OXO 3 PHENYL 2 PROPENYL]PIPERAZINE; 4 (3,4 DICHLOROPHENYLMETHYL) 1 [3 (3,4 DIHYDROXYPHENYL) 1 OXO 2 PROPENYL]PIPERAZINE; 4 (3,4 DICHLOROPHENYLMETHYL) 1 [3 (3,4 DIMETHOXYPHENYL) 1 OXO 2 PROPENYL]PIPERAZINE; 4 (3,4 DICHLOROPHENYLMETHYL) 1 [3 (3,5 DIMETHOXY 4 (4 ETHOXYPHENYL METHOXY) PHENYL 1 OXO 2 PROPENYL]PIPERAZINE; CAFFEIC ACID DERIVATIVE; CAFFEIC ACID PHENETHYL ESTER; CISPLATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL ACTIVITY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MITOCHONDRION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AZA COMPOUNDS; CAFFEIC ACIDS; CELL LINE, TUMOR; FLOW CYTOMETRY; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955982931     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.016     Document Type: Article

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