-
1
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR, et al.: Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002, 347:975-982.
-
(2002)
N Engl J Med
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
2
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
Manns MP, McHutchison JG, Gordon SC, et al.: Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001, 358:958-965.
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
-
3
-
-
49649122545
-
Metabolic syndrome as a cardiovascular disease risk factor: Patients evaluated in primary care
-
Cabre JJ, Martin F, Costa B, et al.: Metabolic syndrome as a cardiovascular disease risk factor: Patients evaluated in primary care. BMC Public Health 2008, 8:251.
-
(2008)
BMC Public Health
, vol.8
, pp. 251
-
-
Cabre, J.J.1
Martin, F.2
Costa, B.3
-
4
-
-
0035897696
-
Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults: Executive summary of the third report on the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol inadults (Adult Treatment Panel III)
-
Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults: executive summary of the third report on the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol inadults (Adult Treatment Panel III). J Am Med Assoc 2001, 285:2486-2497.
-
(2001)
J Am Med Assoc
, vol.285
, pp. 2486-2497
-
-
-
5
-
-
70349256049
-
Impact of obesity, steatosis and insulin resistance on progression and response to therapy of hepatitis C
-
Negro F, Clement S: Impact of obesity, steatosis and insulin resistance on progression and response to therapy of hepatitis C. J Viral Hepat 2009, 16:681-688.
-
(2009)
J Viral Hepat
, vol.16
, pp. 681-688
-
-
Negro, F.1
Clement, S.2
-
6
-
-
33745019825
-
Impact of obesity on degree of liver disease and response to therapy in patients with chronic hepatitis C virus infection
-
Cesario K, Khandwala F, Edwards K, et al.: Impact of obesity on degree of liver disease and response to therapy in patients with chronic hepatitis C virus infection. J Hepatol 2005, 42(Suppl 2):201-202.
-
(2005)
J Hepatol
, vol.42
, Issue.SUPPL 2
, pp. 201-202
-
-
Cesario, K.1
Khandwala, F.2
Edwards, K.3
-
7
-
-
0345655291
-
Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression
-
Hui JM, Sud A, Farrell GC, et al.: Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression. Gastroenterology 2003, 123:1695-1704.
-
(2003)
Gastroenterology
, vol.123
, pp. 1695-1704
-
-
Hui, J.M.1
Sud, A.2
Farrell, G.C.3
-
8
-
-
7244243810
-
Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through upregulation of suppressor of cytokine signaling 3
-
Kawaguchi T, Yoshida T, Harada M, et al.: Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through upregulation of suppressor of cytokine signaling 3. Am J Pathol 2004, 165:1499-1508.
-
(2004)
Am J Pathol
, vol.165
, pp. 1499-1508
-
-
Kawaguchi, T.1
Yoshida, T.2
Harada, M.3
-
9
-
-
0033933140
-
Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
-
Rubbia-Brandt L, Quadri R, Abid K, et al.: Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3. J Hepatol 2000, 33(1):106115.
-
(2000)
J Hepatol
, vol.33
, Issue.1
, pp. 106115
-
-
Rubbia-Brandt, L.1
Quadri, R.2
Abid, K.3
-
10
-
-
33644882808
-
Peroxisome proliferator-activated receptor-alpha and gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection
-
De Gottardi A, Pazienza V, Pugnale P, et al.: Peroxisome proliferator-activated receptor-alpha and gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection. Aliment Pharmacol Ther 2006, 23:107-114.
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 107-114
-
-
De Gottardi, A.1
Pazienza, V.2
Pugnale, P.3
-
11
-
-
30944455145
-
Insulin resistance: A metabolic pathway to chronic liver disease
-
Bugianesie E, McCullough AJ, Marchesini G: Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005, 42:987-1000.
-
(2005)
Hepatology
, vol.42
, pp. 987-1000
-
-
Bugianesie, E.1
McCullough, A.J.2
Marchesini, G.3
-
13
-
-
84865627930
-
-
National health statistics reports: no. 13 Hyattsville, MD: National Center for Health Statistics;
-
Ervin RB: Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race, and ethnicity, and body mass index: United States, 2003-2006. National health statistics reports: no.13 Hyattsville, MD: National Center for Health Statistics; 2009.
-
(2009)
Prevalence of Metabolic Syndrome among Adults 20 Years of Age and Over, by Sex, Age, Race, and Ethnicity, and Body Mass Index: United States, 2003-2006
-
-
Ervin, R.B.1
-
14
-
-
59349100512
-
Metabolic syndrome in veterans with chronic HCV infection correlates with NAFLD activity score
-
abstract s1915
-
Pandya PK, Shah P, Callahan P, et al.: Metabolic syndrome in veterans with chronic HCV infection correlates with NAFLD activity score. Gastroenterology 2006, 130(Suppl 2):A284, abstract s1915.
-
(2006)
Gastroenterology
, vol.130
, Issue.SUPPL 2
-
-
Pandya, P.K.1
Shah, P.2
Callahan, P.3
-
15
-
-
42949174135
-
Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection
-
Hanouneh IA, Feldstein AE, Lopez R, et al.: Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection. Clin Gastroenterol Hepatol 2008, 6(5):584-589.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, Issue.5
, pp. 584-589
-
-
Hanouneh, I.A.1
Feldstein, A.E.2
Lopez, R.3
-
16
-
-
0033038672
-
Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
-
Matteoni CA, Younossi ZM, Gramlich T, et al.: Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
-
(1999)
Gastroenterology
, vol.116
, pp. 1413-1419
-
-
Matteoni, C.A.1
Younossi, Z.M.2
Gramlich, T.3
-
17
-
-
36749090655
-
Metabolic syndrome is associated with severe fibrosis in chronic viral hepatitis and non-alcoholic steatohepatitis
-
This study demonstrated the link between metabolic syndrome and disease progression in chronic hepatitis C virus
-
Tsochatzis E, Papatheodoridis GV, Manesis EK, et al.: Metabolic syndrome is associated with severe fibrosis in chronic viral hepatitis and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2008, 27:80-89. This study demonstrated the link between metabolic syndrome and disease progression in chronic hepatitis C virus.
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 80-89
-
-
Tsochatzis, E.1
Papatheodoridis, G.V.2
Manesis, E.K.3
-
18
-
-
33749186908
-
Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLD
-
Kang H, Greenson JK, Omo JT, et al.: Metabolic syndrome is associated with greater histologic severity, higher carbohydrate, and lower fat diet in patients with NAFLD. Am J Gastroenterol 2006, 101:2247-2253.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 2247-2253
-
-
Kang, H.1
Greenson, J.K.2
Omo, J.T.3
-
19
-
-
0037382786
-
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
-
Marchesini G, Bugianesi E, Forlani G, et al.: Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003, 37:917-923.
-
(2003)
Hepatology
, vol.37
, pp. 917-923
-
-
Marchesini, G.1
Bugianesi, E.2
Forlani, G.3
-
20
-
-
0028985869
-
High prevalence of hepatitis C infection in Afro-Caribbean patients with type 2 diabetes and abnormal liver function tests
-
Gray H, Wreghitt T, Stratton IM, et al.: High prevalence of hepatitis C infection in Afro-Caribbean patients with type 2 diabetes and abnormal liver function tests. Diabet Med 1995, 12:244-249.
-
(1995)
Diabet Med
, vol.12
, pp. 244-249
-
-
Gray, H.1
Wreghitt, T.2
Stratton, I.M.3
-
21
-
-
33646000608
-
Diabetes mellitus in chronic hepatitis B and C: Prevalence and potential association with the extent of liver fibrosis
-
Papatheodoridis GV, Chrysanthos N, Savvas S, et al.: Diabetes mellitus in chronic hepatitis B and C: prevalence and potential association with the extent of liver fibrosis. J Viral Hepat 2006, 13:303-310.
-
(2006)
J Viral Hepat
, vol.13
, pp. 303-310
-
-
Papatheodoridis, G.V.1
Chrysanthos, N.2
Savvas, S.3
-
22
-
-
0033025254
-
Association of diabetes mellitus and chronic hepatis C virus infection
-
Mason AL, Lau JY, Hoang N, et al.: Association of diabetes mellitus and chronic hepatis C virus infection. Hepatology 1999, 29:328-333.
-
(1999)
Hepatology
, vol.29
, pp. 328-333
-
-
Mason, A.L.1
Lau, J.Y.2
Hoang, N.3
-
23
-
-
59349102306
-
Metabolic syndrome, nonalcoholic fatty liver disease and hepatitis C virus: Impact on disease progression and treatment response
-
Younossi ZM, McCullough AJ: Metabolic syndrome, nonalcoholic fatty liver disease and hepatitis C virus: impact on disease progression and treatment response. Liver Int 2009, 29 (Suppl 2):3-12.
-
(2009)
Liver Int
, vol.29
, Issue.SUPPL 2
, pp. 3-12
-
-
Younossi, Z.M.1
McCullough, A.J.2
-
24
-
-
33847316067
-
Clearance of HCV improves insulin resistance, B-cell function, and hepatic expression of insulin receptor substrate 1 and 2
-
This study correlated the clearance of HCV and insulin resistance with insulin receptor substrate signaling
-
Kawaguchi T, Ide T, Taniguchi E, et al.: Clearance of HCV improves insulin resistance, B-cell function, and hepatic expression of insulin receptor substrate 1 and 2. Am J Gastroenterol 2007, 102(3):570-576. This study correlated the clearance of HCV and insulin resistance with insulin receptor substrate signaling.
-
(2007)
Am J Gastroenterol
, vol.102
, Issue.3
, pp. 570-576
-
-
Kawaguchi, T.1
Ide, T.2
Taniguchi, E.3
-
25
-
-
0037242550
-
The liver, liver disease, and diabetes ellitus
-
Albright E, Bell D: The liver, liver disease, and diabetes ellitus. Endocrinologist 2003, 13:58-66.
-
(2003)
Endocrinologist
, vol.13
, pp. 58-66
-
-
Albright, E.1
Bell, D.2
-
27
-
-
1542287381
-
Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance
-
Shintani Y, Fujie H, Moyoshi H, et al.: Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance. Gastroenterology 2004, 126:840-848.
-
(2004)
Gastroenterology
, vol.126
, pp. 840-848
-
-
Shintani, Y.1
Fujie, H.2
Moyoshi, H.3
-
28
-
-
59449099132
-
Hepatitis C, insulin resistance and diabetes: Clinical and pathogenic data
-
Serfaty L, Capeau J.: Hepatitis C, insulin resistance and diabetes: clinical and pathogenic data. Liver International 2009, 29(Suppl 2):13-25.
-
(2009)
Liver International
, vol.29
, Issue.SUPPL 2
, pp. 13-25
-
-
Serfaty, L.1
Capeau, J.2
-
29
-
-
0032587240
-
The role of TNF-alpha and TNF receptors in obesity and insulin resistance
-
Hotamisligil GS.: The role of TNF-alpha and TNF receptors in obesity and insulin resistance. J Intern Med 1999, 245:621-625.
-
(1999)
J Intern Med
, vol.245
, pp. 621-625
-
-
Hotamisligil, G.S.1
-
30
-
-
72049095072
-
Molecular mechanisms of insulin resistance in chronic hepatitis C
-
Douglas MW, George J: Molecular mechanisms of insulin resistance in chronic hepatitis C. World J Gastroenterol 2009, 15 (35):4356-4364.
-
(2009)
World J Gastroenterol
, vol.15
, Issue.35
, pp. 4356-4364
-
-
Douglas, M.W.1
George, J.2
-
31
-
-
34547444610
-
Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines
-
Cua IH, Hui JM, Bandara P, et al.: Insulin resistance and liver injury in hepatitis C is not associated with virus-specific changes in adipocytokines. Hepatology 2007, 46:66-73.
-
(2007)
Hepatology
, vol.46
, pp. 66-73
-
-
Cua, I.H.1
Hui, J.M.2
Bandara, P.3
-
32
-
-
62749155010
-
Hepatitis C virus and glucose and lipid metabolism
-
Alaei M, Negro F: Hepatitis C virus and glucose and lipid metabolism. Diabetes Metab 2008, 34:692-700.
-
(2008)
Diabetes Metab
, vol.34
, pp. 692-700
-
-
Alaei, M.1
Negro, F.2
-
33
-
-
0345017776
-
Impaired IRS-1/P13- kinase signaling in patients with HCV: A mechanism for increased prevalence of type 2 diabetes
-
Aytug S, Reich D, Sapiro LE, et al.: Impaired IRS-1/P13- kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology 2003, 38:1384-1392.
-
(2003)
Hepatology
, vol.38
, pp. 1384-1392
-
-
Aytug, S.1
Reich, D.2
Sapiro, L.E.3
-
34
-
-
40149089262
-
Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance
-
Banerjee S, Saito K, Ait-Goughoulte M, et al.: Hepatitis C virus core protein upregulates serine phosphorylation of insulin receptor substrate-1 and impairs the downstream akt/protein kinase B signaling pathway for insulin resistance. J Virol 2008, 82:2606-2612.
-
(2008)
J Virol
, vol.82
, pp. 2606-2612
-
-
Banerjee, S.1
Saito, K.2
Ait-Goughoulte, M.3
-
35
-
-
33846849610
-
Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein
-
Miyamoto H, Moriishi K, Moriya K, et al.: Involvement of the PA28gamma-dependent pathway in insulin resistance induced by hepatitis C virus core protein. J Virol 2007, 81:1727-1735.
-
(2007)
J Virol
, vol.81
, pp. 1727-1735
-
-
Miyamoto, H.1
Moriishi, K.2
Moriya, K.3
-
36
-
-
34248671715
-
The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
-
Pazienza V, Clement S, Pugnale P, et al.: The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms. Hepatology 2007, 45:1164-1171.
-
(2007)
Hepatology
, vol.45
, pp. 1164-1171
-
-
Pazienza, V.1
Clement, S.2
Pugnale, P.3
-
37
-
-
3142723189
-
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
-
Ueki K, Kondo T, Tseng YH, et al.: Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A 2004, 101:10422-10427.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 10422-10427
-
-
Ueki, K.1
Kondo, T.2
Tseng, Y.H.3
-
38
-
-
33645114359
-
Non-response to antiviral therapy is associated with obesity and increased expression of hepatic expression of suppressor of cytokine signaling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
-
Walsh M, Jonsson J, Richardson M, et al.: Non-response to antiviral therapy is associated with obesity and increased expression of hepatic expression of suppressor of cytokine signaling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006, 55:529-535.
-
(2006)
Gut
, vol.55
, pp. 529-535
-
-
Walsh, M.1
Jonsson, J.2
Richardson, M.3
-
39
-
-
48449100910
-
Virus-induced overexpression of protein phosphatase 2A inhibits insulin signaling in chronic hepatitis C
-
Bernsmeier C, Duong FH, Christen V, et al.: Virus-induced overexpression of protein phosphatase 2A inhibits insulin signaling in chronic hepatitis C. J Hepatol 2008, 49:429-440.
-
(2008)
J Hepatol
, vol.49
, pp. 429-440
-
-
Bernsmeier, C.1
Duong, F.H.2
Christen, V.3
-
40
-
-
77449150552
-
Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance
-
This study challenges current thinking about the exact site of insulin resistance
-
Milner KL, van der Poorten D, Trenell M, et al.: Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance. Gastroenterology 2010, 138(3):932-941. This study challenges current thinking about the exact site of insulin resistance.
-
(2010)
Gastroenterology
, vol.138
, Issue.3
, pp. 932-941
-
-
Milner, K.L.1
Van Der Poorten, D.2
Trenell, M.3
-
41
-
-
66749149895
-
Insulin resistance and steatosis in chronic hepatitis C
-
Machado MV, Cortez-Pinto H: Insulin resistance and steatosis in chronic hepatitis C. Ann Hepatol 2009, 8(Suppl 1):S67-S75.
-
(2009)
Ann Hepatol
, vol.8
, Issue.SUPPL 1
-
-
MacHado, M.V.1
Cortez-Pinto, H.2
-
42
-
-
73449102141
-
Steatosis and insulin resistance in hepatitis C: A way out for the virus?
-
Del Campo JA, Romero-Gomez M: Steatosis and insulin resistance in hepatitis C: A way out for the virus? World J Gastroenterol 2009, 15(40):5014-5019.
-
(2009)
World J Gastroenterol
, vol.15
, Issue.40
, pp. 5014-5019
-
-
Del Campo, J.A.1
Romero-Gomez, M.2
-
43
-
-
34548130208
-
The genotype 3- specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model
-
Hourioux C, Patient R, Morin A, et al.: The genotype 3- specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut 2007, 56:1302-1308.
-
(2007)
Gut
, vol.56
, pp. 1302-1308
-
-
Hourioux, C.1
Patient, R.2
Morin, A.3
-
44
-
-
55649094639
-
Interaction of metabolic syndrome, nonalcoholic fatty liver disease and chronic hepatitis C
-
Rafiq N, Younossi ZM: Interaction of metabolic syndrome, nonalcoholic fatty liver disease and chronic hepatitis C. Expert Rev. Gastroenterol Hepatol 2008, 2(2):207-215.
-
(2008)
Expert Rev. Gastroenterol Hepatol
, vol.2
, Issue.2
, pp. 207-215
-
-
Rafiq, N.1
Younossi, Z.M.2
-
45
-
-
47949092185
-
Insulin resistance among patients with chronic hepatitis c: Etiology and impact on treatment
-
Harrison SA: Insulin resistance among patients with chronic hepatitis c: etiology and impact on treatment. Clin Gastroenterol Hepatol 2008, 6:864-876.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 864-876
-
-
Harrison, S.A.1
-
46
-
-
46349099383
-
Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin
-
Overbeck K, Genne D, Golay A, et al.: Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin. J Hepatol 2008, 49(2):295-298.
-
(2008)
J Hepatol
, vol.49
, Issue.2
, pp. 295-298
-
-
Overbeck, K.1
Genne, D.2
Golay, A.3
-
47
-
-
72549104493
-
Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin
-
Romero-Gomez M, Diago M, Andrade RJ, et al.: Treatment of insulin resistance with metformin in naïve genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin. Hepatology 2009, 50(6):1702-1708.
-
(2009)
Hepatology
, vol.50
, Issue.6
, pp. 1702-1708
-
-
Romero-Gomez, M.1
Diago, M.2
Andrade, R.J.3
|