-
1
-
-
0034101804
-
Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro
-
Reubinoff, B.E., Pera, M.F., Fong, C.Y., Trounson, A. and Bongso, A. (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat. Biotechnol. 18, 399-404
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 399-404
-
-
Reubinoff, B.E.1
Pera, M.F.2
Fong, C.Y.3
Trounson, A.4
Bongso, A.5
-
2
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S. and Jones, J.M. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
Itskovitz-Eldor, J.2
Shapiro, S.S.3
Waknitz, M.A.4
Swiergiel, J.J.5
Marshall, V.S.6
Jones, J.M.7
-
3
-
-
64549140750
-
Human embryonic stem cell technologies and drug discovery
-
Jensen, J., Hyllner, J. and Björquist, P. (2009) Human embryonic stem cell technologies and drug discovery. J. Cell Physiol. 219, 513-519
-
(2009)
J. Cell Physiol.
, vol.219
, pp. 513-519
-
-
Jensen, J.1
Hyllner, J.2
Björquist, P.3
-
4
-
-
69549108053
-
Stem cells in drug discovery, tissue engineering, and regenerative medicine: Emerging opportunities and challenges
-
Nirmalanandhan, V.S. and Sittampalam, G.S. (2009) Stem cells in drug discovery, tissue engineering, and regenerative medicine: emerging opportunities and challenges. J. Biomol. Screen. 14, 755-768
-
(2009)
J. Biomol. Screen.
, vol.14
, pp. 755-768
-
-
Nirmalanandhan, V.S.1
Sittampalam, G.S.2
-
5
-
-
34547620338
-
Embryonic stem cells as a source of models for drug discovery
-
Pouton, C.W. and Haynes, J.M. (2007) Embryonic stem cells as a source of models for drug discovery. Nat. Rev. Drug Discov. 6, 605-616
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 605-616
-
-
Pouton, C.W.1
Haynes, J.M.2
-
6
-
-
2942591062
-
Derivation, characterization, and differentiation of human embryonic stem cells
-
Heins, N., Englund, M.C., Sjoblom, C., Dahl, U., Tonning, A., Bergh, C., Lindahl, A., Hanson, C. and Semb, H. (2004) Derivation, characterization, and differentiation of human embryonic stem cells. Stem Cells 22, 367-376
-
(2004)
Stem Cells
, vol.22
, pp. 367-376
-
-
Heins, N.1
Englund, M.C.2
Sjoblom, C.3
Dahl, U.4
Tonning, A.5
Bergh, C.6
Lindahl, A.7
Hanson, C.8
Semb, H.9
-
7
-
-
33744982066
-
A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells
-
Liu, Y., Song, Z., Zhao, Y., Qin, H., Cai, J., Zhang, H., Yu, T., Jiang, S., Wang, G., Ding, M. and Deng, H. (2006) A novel chemical-defined medium with bFGF and N2B27 supplements supports undifferentiated growth in human embryonic stem cells. Biochem. Biophys. Res. Commun. 346, 131-139
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.346
, pp. 131-139
-
-
Liu, Y.1
Song, Z.2
Zhao, Y.3
Qin, H.4
Cai, J.5
Zhang, H.6
Yu, T.7
Jiang, S.8
Wang, G.9
Ding, M.10
Deng, H.11
-
8
-
-
0030974622
-
Tailoring cAMP-signalling responses through isoform multiplicity
-
Houslay, M.D. and Milligan, G. (1997) Tailoring cAMP-signalling responses through isoform multiplicity. Trends Biochem. Sci. 22, 217-224
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 217-224
-
-
Houslay, M.D.1
Milligan, G.2
-
9
-
-
75749117558
-
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown
-
Houslay, M.D. (2010) Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends Biochem. Sci. 35, 91-100
-
(2010)
Trends Biochem. Sci.
, vol.35
, pp. 91-100
-
-
Houslay, M.D.1
-
10
-
-
0037443097
-
PDE4 cAMP phosphodiesterases: Modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
-
Houslay, M.D. and Adams, D.R. (2003) PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem. J. 370, 1-18
-
(2003)
Biochem. J.
, vol.370
, pp. 1-18
-
-
Houslay, M.D.1
Adams, D.R.2
-
11
-
-
0029962380
-
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram
-
Michie, A.M., Lobban, M., Muller, T., Harnett, M.M. and Houslay, M.D. (1996) Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. Cell. Signalling 8, 97-110
-
(1996)
Cell. Signalling
, vol.8
, pp. 97-110
-
-
Michie, A.M.1
Lobban, M.2
Muller, T.3
Harnett, M.M.4
Houslay, M.D.5
-
12
-
-
8844220521
-
Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
-
Boess, F.G., Hendrix, M., van der Staay, F.J., Erb, C., Schreiber, R., van Staveren, W., de Vente, J., Prickaerts, J., Blokland, A. and Koenig, G. (2004) Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology 47, 1081-1092
-
(2004)
Neuropharmacology
, vol.47
, pp. 1081-1092
-
-
Boess, F.G.1
Hendrix, M.2
Van Der Staay, F.J.3
Erb, C.4
Schreiber, R.5
Van Staveren, W.6
De Vente, J.7
Prickaerts, J.8
Blokland, A.9
Koenig, G.10
-
13
-
-
33646795266
-
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes
-
Castro, L.R., Verde, I., Cooper, D.M. and Fischmeister, R. (2006) Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes. Circulation 113, 2221-2228
-
(2006)
Circulation
, vol.113
, pp. 2221-2228
-
-
Castro, L.R.1
Verde, I.2
Cooper, D.M.3
Fischmeister, R.4
-
14
-
-
31144433061
-
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
-
Lugnier, C. (2006) Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol. Ther. 109, 366-398
-
(2006)
Pharmacol. Ther.
, vol.109
, pp. 366-398
-
-
Lugnier, C.1
-
15
-
-
0017226235
-
Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis
-
Carson, D.A. and Seegmiller, J.E. (1976) Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. J. Clin. Invest. 57, 274-282
-
(1976)
J. Clin. Invest.
, vol.57
, pp. 274-282
-
-
Carson, D.A.1
Seegmiller, J.E.2
-
16
-
-
34547104376
-
Inhibition of adenosine deaminase attenuates inflammation in experimental colitis
-
Antonioli, L., Fornai, M., Colucci, R., Ghisu, N., Da Settimo, F., Natale, G., Kastsiuchenka, O., Duranti, E., Virdis, A., Vassalle, C. et al. (2007) Inhibition of adenosine deaminase attenuates inflammation in experimental colitis. J. Pharmacol. Exp. Ther. 322, 435-442
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.322
, pp. 435-442
-
-
Antonioli, L.1
Fornai, M.2
Colucci, R.3
Ghisu, N.4
Da Settimo, F.5
Natale, G.6
Kastsiuchenka, O.7
Duranti, E.8
Virdis, A.9
Vassalle, C.10
-
17
-
-
0036560298
-
Mechanisms of apoptosis induced by purine nucleosides in astrocytes
-
Di Iorio, P., Kleywegt, S., Ciccarelli, R., Traversa, U., Andrew, C.M., Crocker, C.E., Werstiuk, E.S. and Rathbone, M.P. (2002) Mechanisms of apoptosis induced by purine nucleosides in astrocytes. Glia 38, 179-190
-
(2002)
Glia
, vol.38
, pp. 179-190
-
-
Di Iorio, P.1
Kleywegt, S.2
Ciccarelli, R.3
Traversa, U.4
Andrew, C.M.5
Crocker, C.E.6
Werstiuk, E.S.7
Rathbone, M.P.8
-
18
-
-
27144519159
-
Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway
-
Hashemi, M., Karami-Tehrani, F., Ghavami, S., Maddika, S. and Los, M. (2005) Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway. Cell Prolif. 38, 269-285
-
(2005)
Cell Prolif.
, vol.38
, pp. 269-285
-
-
Hashemi, M.1
Karami-Tehrani, F.2
Ghavami, S.3
Maddika, S.4
Los, M.5
-
19
-
-
12344281073
-
New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency
-
Hershfield, M.S. (2005) New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency Eur. J. Immunol. 35, 25-30
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 25-30
-
-
Hershfield, M.S.1
-
20
-
-
0031969148
-
Absorption and intestinal metabolism of purine dideoxynucleosides and an adenosine deaminase-activated prodrug of 2′,3′-dideoxyinosine in the mesenteric vein cannulated rat ileum
-
Singhal, D. and Anderson, B.D. (1998) Absorption and intestinal metabolism of purine dideoxynucleosides and an adenosine deaminase-activated prodrug of 2′,3′-dideoxyinosine in the mesenteric vein cannulated rat ileum. J. Pharmacol. Sci. 87, 578-585
-
(1998)
J. Pharmacol. Sci.
, vol.87
, pp. 578-585
-
-
Singhal, D.1
Anderson, B.D.2
-
21
-
-
0035464774
-
Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in rats
-
Tofovic, S.P., Zacharia, L., Carcillo, J.A. and Jackson, E.K. (2001) Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in rats. Shock 16, 196-202
-
(2001)
Shock
, vol.16
, pp. 196-202
-
-
Tofovic, S.P.1
Zacharia, L.2
Carcillo, J.A.3
Jackson, E.K.4
-
22
-
-
1842455198
-
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: Dawn of a new era
-
Nabhan, C., Gartenhaus, R.B. and and Tallman, M.S. (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leuk. Res. 28, 429-442
-
(2004)
Leuk. Res.
, vol.28
, pp. 429-442
-
-
Nabhan, C.1
Gartenhaus, R.B.2
Tallman, M.S.3
-
23
-
-
70349490598
-
Pentostatin treatment combinations in chronic lymphocytic leukemia
-
Lamanna, N. and Kay, N.E. (2009) Pentostatin treatment combinations in chronic lymphocytic leukemia. Clin. Adv. Hematol. Oncol. 7, 386-392
-
(2009)
Clin. Adv. Hematol. Oncol.
, vol.7
, pp. 386-392
-
-
Lamanna, N.1
Kay, N.E.2
-
24
-
-
63449116519
-
Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases
-
Robak, T., Korycka, A., Lech-Maranda, E. and Robak, P. (2009) Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules 14, 1183-1226
-
(2009)
Molecules
, vol.14
, pp. 1183-1226
-
-
Robak, T.1
Korycka, A.2
Lech-Maranda, E.3
Robak, P.4
-
25
-
-
33847080728
-
AMP-activated protein kinase in metabolic control and insulin signaling
-
Robak, T., Korycka, A., Lech-Maranda, E. and Robak, P. (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 100, 328-341
-
(2007)
Circ. Res.
, vol.100
, pp. 328-341
-
-
Robak, T.1
Korycka, A.2
Lech-Maranda, E.3
Robak, P.4
-
26
-
-
66949121471
-
AMP-activated protein kinase pathway: A potential therapeutic target in cardiometabolic disease
-
Wong, A.K., Howie, J., Petrie, J.R. and Lang, C.C. (2009) AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin. Sci. 116, 607-620
-
(2009)
Clin. Sci.
, vol.116
, pp. 607-620
-
-
Wong, A.K.1
Howie, J.2
Petrie, J.R.3
Lang, C.C.4
-
27
-
-
70349318057
-
Introduction to adenosine receptors as therapeutic targets
-
Jacobson, K.A. (2009) Introduction to adenosine receptors as therapeutic targets. Handb. Exp. Pharmacol. 193, 1-24
-
(2009)
Handb. Exp. Pharmacol.
, vol.193
, pp. 1-24
-
-
Jacobson, K.A.1
-
28
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P. and Brivanlou, A.H. (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10, 55-63
-
(2004)
Nat. Med.
, vol.10
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
29
-
-
33947233409
-
MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal
-
Li, J., Wang, G., Wang, C., Zhao, Y., Zhang, H., Tan, Z., Song, Z., Ding, M. and Deng, H. (2007) MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal. Differentiation 75, 299-307
-
(2007)
Differentiation
, vol.75
, pp. 299-307
-
-
Li, J.1
Wang, G.2
Wang, C.3
Zhao, Y.4
Zhang, H.5
Tan, Z.6
Song, Z.7
Ding, M.8
Deng, H.9
-
30
-
-
25444503012
-
Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells
-
Dvorak, P., Dvorakova, D., Koskova, S., Vodinska, M., Najvirtova, M., Krekac, D. and Hampl, A. (2005) Expression and potential role of fibroblast growth factor 2 and its receptors in human embryonic stem cells. Stem Cells 23, 1200-1211
-
(2005)
Stem Cells
, vol.23
, pp. 1200-1211
-
-
Dvorak, P.1
Dvorakova, D.2
Koskova, S.3
Vodinska, M.4
Najvirtova, M.5
Krekac, D.6
Hampl, A.7
|