Mapping of liver-enriched transcription factors in the human intestine

World Journal of Gastroenterology

Volumn 16, Issue 31, 2010, Pages 3919-3927

  Lehner, Frank ^a   Kulik, Ulf ^a   Klempnauer, Juergen ^a   Borlak, Juergen ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Caco 2; Gene expression; Human intestine; Liver enriched transcription factors

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HEPATOCYTE NUCLEAR FACTOR 6; NEUROGENIN 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; ZINC FINGER PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN CACO 2; COLON; DNA BINDING; DUODENUM; GENE EXPRESSION; GENE MAPPING; HEMICOLECTOMY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; INTESTINE EPITHELIUM; JEJUNUM; PROTEIN EXPRESSION; RECTUM RESECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGMOIDECTOMY; WESTERN BLOTTING;

EID: 77955971401     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v16.i31.3919     Document Type: Article

References (21)

1. Schrem H, Klempnauer J, Borlak J. Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev 2002; 54: 129-158
2. Schrem H, Klempnauer J, Borlak J. Liver-enriched transcription factors in liver function and development. Part II: the C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol Rev 2004; 56: 291-330
3. Rausa F, Samadani U, Ye H, Lim L, Fletcher CF, Jenkins NA, Copeland NG, Costa RH. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev Biol 1997; 192: 228-246
4. Lazarevich NL, Cheremnova OA, Varga EV, Ovchinnikov DA, Kudrjavtseva EI, Morozova OV, Fleishman DI, Engelhardt NV, Duncan SA. Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology 2004; 39: 1038-1047
5. Lehner F, Kulik U, Klempnauer J, Borlak J. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. FASEB J 2007; 21: 1445-1462
6. Pantaleo MA, Astolfi A, Nannini M, Paterini P, Piazzi G, Ercolani G, Brandi G, Martinelli G, Pession A, Pinna AD, Biasco G. Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice. Br J Cancer 2008; 99: 1729-1734
7. Koh KH, Rhee H, Kang HJ, Yang E, You KT, Lee H, Min BS, Kim NK, Nam SW, Kim H. Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas. Oncology 2008; 75: 92-101
8. Engle MJ, Goetz GS, Alpers DH. Caco-2 cells express a combination of colonocyte and enterocyte phenotypes. J Cell Physiol 1998; 174: 362-369
9. Ferraretto A, Gravaghi C, Donetti E, Cosentino S, Donida BM, Bedoni M, Lombardi G, Fiorilli A, Tettamanti G. New methodological approach to induce a differentiation phenotype in Caco-2 cells prior to post-confluence stage. Anticancer Res 2007; 27: 3919-3925
10. Lampen A, Bader A, Bestmann T, Winkler M, Witte L, Borlak JT. Catalytic activities, protein-and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. Xenobiotica 1998; 28: 429-441
11. Niehof M, Streetz K, Rakemann T, Bischoff SC, Manns MP, Horn F, Trautwein C. Interleukin-6-induced tethering of STAT3 to the LAP/C/EBPbeta promoter suggests a new mechanism of transcriptional regulation by STAT3. J Biol Chem 2001; 276: 9016-9027
12. Borlak J, Zwadlo C. Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells. Xenobiotica 2003; 33: 927-943
13. Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 2000; 20: 4445-4454
14. Rausa FM 3rd, Hughes DE, Costa RH. Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator. J Biol Chem 2004; 279: 43070-43076
15. Ahn SH, Shah YM, Inoue J, Morimura K, Kim I, Yim S, Lambert G, Kurotani R, Nagashima K, Gonzalez FJ, Inoue Y. Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease. Inflamm Bowel Dis 2008; 14: 908-920
16. Lussier CR, Babeu JP, Auclair BA, Perreault N, Boudreau F. Hepatocyte nuclear factor-4alpha promotes differentiation of intestinal epithelial cells in a coculture system. Am J Physiol Gastrointest Liver Physiol 2008; 294: G418-G428
17. Stegmann A, Hansen M, Wang Y, Larsen JB, Lund LR, Ritié L, Nicholson JK, Quistorff B, Simon-Assmann P, Troelsen JT, Olsen J. Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation. Physiol Genomics 2006; 27: 141-155
18. van der Sluis M, Vincent A, Bouma J, Korteland-Van Male A, van Goudoever JB, Renes IB, Van Seuningen I. Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. Biochem Biophys Res Commun 2008; 369: 1108-1113
19. Niehof M, Borlak J. EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas. Gastroenterology 2008; 134: 1191-1202
20. Bevilacqua MA, Faniello MC, Iovine B, Russo T, Cimino F, Costanzo F. Transcription factor NF-Y regulates differentiation of CaCo-2 cells. Arch Biochem Biophys 2002; 407: 39-44
21. Ding Q, Wang Q, Dong Z, Evers BM. Characterization and regulation of E2F activity during Caco-2 cell differentiation. Am J Physiol Cell Physiol 2000; 278: C110-C117