메뉴 건너뛰기




Volumn 294, Issue 2, 2008, Pages

Hepatocyte nuclear factor-4α promotes differentiation of intestinal epithelial cells in a coculture system

Author keywords

Differentiation; HNF 1 ; HNF 4 ; Intestinal epithelial cells; Mesenchymal cells

Indexed keywords

CALBINDIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA;

EID: 39149087999     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00418.2007     Document Type: Article
Times cited : (36)

References (63)
  • 1
    • 33744795211 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    • Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci USA 103: 8419-8424, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8419-8424
    • Battle, M.A.1    Konopka, G.2    Parviz, F.3    Gaggl, A.L.4    Yang, C.5    Sladek, F.M.6    Duncan, S.A.7
  • 2
    • 0007625867 scopus 로고    scopus 로고
    • Extracellular matrix components and integrins in relationship to human intestinal epithelial cell differentiation
    • Beaulieu JF. Extracellular matrix components and integrins in relationship to human intestinal epithelial cell differentiation. Prog Histochem Cytochem 31: 1-78, 1997.
    • (1997) Prog Histochem Cytochem , vol.31 , pp. 1-78
    • Beaulieu, J.F.1
  • 3
    • 0035807902 scopus 로고    scopus 로고
    • A transcription factor regulatory circuit in differentiated pancreatic cells
    • Boj SF, Parrizas M, Maestro MA, Ferrer J. A transcription factor regulatory circuit in differentiated pancreatic cells. Proc Natl Acad Sci USA 98: 14481-14486, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 14481-14486
    • Boj, S.F.1    Parrizas, M.2    Maestro, M.A.3    Ferrer, J.4
  • 6
    • 0037200071 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene
    • Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 277: 31909-31917, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 31909-31917
    • Boudreau, F.1    Rings, E.H.2    van Wering, H.M.3    Kim, R.K.4    Swain, G.P.5    Krasinski, S.D.6    Moffett, J.7    Grand, R.J.8    Suh, E.R.9    Traber, P.G.10
  • 7
    • 0035943624 scopus 로고    scopus 로고
    • Sucrase-isomaltase gene transcription requires the hepatocyte nuclear factor-1 (HNF-1) regulatory element and is regulated by the ratio of HNF-1 alpha to HNF-1 beta
    • Boudreau F, Zhu Y, Traber PG. Sucrase-isomaltase gene transcription requires the hepatocyte nuclear factor-1 (HNF-1) regulatory element and is regulated by the ratio of HNF-1 alpha to HNF-1 beta. J Biol Chem 276: 32122-32128, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 32122-32128
    • Boudreau, F.1    Zhu, Y.2    Traber, P.G.3
  • 8
    • 24044524492 scopus 로고    scopus 로고
    • Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells
    • Boulanger J, Vezina A, Mongrain S, Boudreau F, Perreault N, Auclair BA, Laine J, Asselin C, Rivard N. Cdk2-dependent phosphorylation of homeobox transcription factor CDX2 regulates its nuclear translocation and proteasome-mediated degradation in human intestinal epithelial cells. J Biol Chem 280: 18095-18107, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 18095-18107
    • Boulanger, J.1    Vezina, A.2    Mongrain, S.3    Boudreau, F.4    Perreault, N.5    Auclair, B.A.6    Laine, J.7    Asselin, C.8    Rivard, N.9
  • 9
    • 0037621983 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    • Chiba H, Gotoh T, Kojima T, Satohisa S, Kikuchi K, Osanai M, Sawada N. Hepatocyte nuclear factor (HNF)-4alpha triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells. Exp Cell Res 286: 288-297, 2003.
    • (2003) Exp Cell Res , vol.286 , pp. 288-297
    • Chiba, H.1    Gotoh, T.2    Kojima, T.3    Satohisa, S.4    Kikuchi, K.5    Osanai, M.6    Sawada, N.7
  • 10
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
    • Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 7: 349-359, 2006.
    • (2006) Nat Rev Genet , vol.7 , pp. 349-359
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 12
    • 3042676514 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription
    • Eeckhoute J, Formstecher P, Laine B. Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription. Nucleic Acids Res 32: 2586-2593, 2004.
    • (2004) Nucleic Acids Res , vol.32 , pp. 2586-2593
    • Eeckhoute, J.1    Formstecher, P.2    Laine, B.3
  • 13
    • 14744270867 scopus 로고    scopus 로고
    • Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells
    • Escaffit F, Boudreau F, Beaulieu JF. Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 203: 15-26, 2005.
    • (2005) J Cell Physiol , vol.203 , pp. 15-26
    • Escaffit, F.1    Boudreau, F.2    Beaulieu, J.F.3
  • 16
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: From endoderm to cancer
    • Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 19: 877-890, 2005.
    • (2005) Genes Dev , vol.19 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 17
    • 16244388032 scopus 로고    scopus 로고
    • The role of Cdx proteins in intestinal development and cancer
    • Guo RJ, Suh ER, Lynch JP. The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 3: 593-601, 2004.
    • (2004) Cancer Biol Ther , vol.3 , pp. 593-601
    • Guo, R.J.1    Suh, E.R.2    Lynch, J.P.3
  • 18
    • 0023089768 scopus 로고
    • Mesenchyme-dependent differentiation of epithelial progenitor cells in the gut
    • Haffen K, Kedinger M, Simon-Assmann P. Mesenchyme-dependent differentiation of epithelial progenitor cells in the gut. J Pediatr Gastroenterol Nutr 6: 14-23, 1987.
    • (1987) J Pediatr Gastroenterol Nutr , vol.6 , pp. 14-23
    • Haffen, K.1    Kedinger, M.2    Simon-Assmann, P.3
  • 20
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21: 1393-1403, 2001.
    • (2001) Mol Cell Biol , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 23
    • 0028243649 scopus 로고
    • Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium
    • James R, Erler T, Kazenwadel J. Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium. J Biol Chem 269: 15229-15237, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 15229-15237
    • James, R.1    Erler, T.2    Kazenwadel, J.3
  • 24
    • 0022457698 scopus 로고
    • Fetal gut mesenchyme induces differentiation of cultured intestinal endodermal and crypt cells
    • Kedinger M, Simon-Assmann PM, Lacroix B, Marxer A, Hauri HP, Haffen K. Fetal gut mesenchyme induces differentiation of cultured intestinal endodermal and crypt cells. Dev Biol 113: 474-483, 1986.
    • (1986) Dev Biol , vol.113 , pp. 474-483
    • Kedinger, M.1    Simon-Assmann, P.M.2    Lacroix, B.3    Marxer, A.4    Hauri, H.P.5    Haffen, K.6
  • 25
    • 0030848766 scopus 로고    scopus 로고
    • Modulation of hepatic gene expression by hepatocyte nuclear factor 1
    • Ktistaki E, Talianidis I. Modulation of hepatic gene expression by hepatocyte nuclear factor 1. Science 277: 109-112, 1997.
    • (1997) Science , vol.277 , pp. 109-112
    • Ktistaki, E.1    Talianidis, I.2
  • 28
    • 0034090310 scopus 로고    scopus 로고
    • Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
    • Li J, Ning G, Duncan SA. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. Genes Dev 14: 464-474, 2000.
    • (2000) Genes Dev , vol.14 , pp. 464-474
    • Li, J.1    Ning, G.2    Duncan, S.A.3
  • 30
    • 24644496823 scopus 로고    scopus 로고
    • Mammalian tight junctions in the regulation of epithelial differentiation and proliferation
    • Matter K, Aijaz S, Tsapara A, Balda MS. Mammalian tight junctions in the regulation of epithelial differentiation and proliferation. Curr Opin Cell Biol 17: 453-458, 2005.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 453-458
    • Matter, K.1    Aijaz, S.2    Tsapara, A.3    Balda, M.S.4
  • 31
    • 0034163801 scopus 로고    scopus 로고
    • Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene
    • Mitchelmore C, Troelsen JT, Spodsberg N, Sjostrom H, Noren O. Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene. Biochem J 346: 529-535, 2000.
    • (2000) Biochem J , vol.346 , pp. 529-535
    • Mitchelmore, C.1    Troelsen, J.T.2    Spodsberg, N.3    Sjostrom, H.4    Noren, O.5
  • 32
    • 16844365885 scopus 로고    scopus 로고
    • Molecular perspective on tight-junction assembly and epithelial polarity
    • Miyoshi J, Takai Y. Molecular perspective on tight-junction assembly and epithelial polarity. Adv Drug Delivery Res 57: 815-855, 2005.
    • (2005) Adv Drug Delivery Res , vol.57 , pp. 815-855
    • Miyoshi, J.1    Takai, Y.2
  • 33
    • 0033016823 scopus 로고    scopus 로고
    • Development of the human gastrointestinal tract: Twenty years of progress
    • Montgomery RK, Mulberg AE, Grand RJ. Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 116: 702-731, 1999.
    • (1999) Gastroenterology , vol.116 , pp. 702-731
    • Montgomery, R.K.1    Mulberg, A.E.2    Grand, R.J.3
  • 34
    • 33645469482 scopus 로고    scopus 로고
    • Stem cells and their niches
    • Moore KA, Lemischka IR. Stem cells and their niches. Science 311: 1880-1885, 2006.
    • (2006) Science , vol.311 , pp. 1880-1885
    • Moore, K.A.1    Lemischka, I.R.2
  • 35
    • 0035699287 scopus 로고    scopus 로고
    • Characterization of variability in large-scale gene expression data: Implications for study design
    • Novak JP, Sladek R, Hudson TJ. Characterization of variability in large-scale gene expression data: implications for study design. Genomics 79: 104-113, 2002.
    • (2002) Genomics , vol.79 , pp. 104-113
    • Novak, J.P.1    Sladek, R.2    Hudson, T.J.3
  • 37
    • 22544476811 scopus 로고    scopus 로고
    • Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells
    • Olsen L, Bressendorff S, Troelsen JT, Olsen J. Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. Am J Physiol Gastrointest Liver Physiol 289: G220-G226, 2005.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Olsen, L.1    Bressendorff, S.2    Troelsen, J.T.3    Olsen, J.4
  • 38
    • 0030010377 scopus 로고    scopus 로고
    • Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures
    • Perreault N, Jean-Francois B. Use of the dissociating enzyme thermolysin to generate viable human normal intestinal epithelial cell cultures. Exp Cell Res 224: 354-364, 1996.
    • (1996) Exp Cell Res , vol.224 , pp. 354-364
    • Perreault, N.1    Jean-Francois, B.2
  • 39
    • 0035900666 scopus 로고    scopus 로고
    • Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut
    • Perreault N, Katz JP, Sackett SD, Kaestner KH. Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut. J Biol Chem 276: 43328-43333, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 43328-43333
    • Perreault, N.1    Katz, J.P.2    Sackett, S.D.3    Kaestner, K.H.4
  • 40
    • 0025641727 scopus 로고
    • Stem cells: Attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt
    • Potten CS, Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 110: 1001-1020, 1990.
    • (1990) Development , vol.110 , pp. 1001-1020
    • Potten, C.S.1    Loeffler, M.2
  • 42
    • 0019825888 scopus 로고
    • Cytotoxic effects and metabolism of benzo[a] pyrene and 7,12-dimethylbenz[a]anthracene in duodenal and ileal epithelial cell cultures
    • Quaroni A, Isselbacher KJ. Cytotoxic effects and metabolism of benzo[a] pyrene and 7,12-dimethylbenz[a]anthracene in duodenal and ileal epithelial cell cultures. J Natl Cancer Inst 67: 1353-1362, 1981.
    • (1981) J Natl Cancer Inst , vol.67 , pp. 1353-1362
    • Quaroni, A.1    Isselbacher, K.J.2
  • 43
    • 0018394382 scopus 로고
    • Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria
    • Quaroni A, Wands J, Trelstad RL, Isselbacher KJ. Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 80: 248-265, 1979.
    • (1979) J Cell Biol , vol.80 , pp. 248-265
    • Quaroni, A.1    Wands, J.2    Trelstad, R.L.3    Isselbacher, K.J.4
  • 44
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: Two sides of a coin
    • Radtke F, Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science 307: 1904-1909, 2005.
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 45
    • 0035214124 scopus 로고    scopus 로고
    • Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity
    • Rings EH, Boudreau F, Taylor JK, Moffett J, Suh ER, Traber PG. Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity. Gastroenterology 121: 1437-1450, 2001.
    • (2001) Gastroenterology , vol.121 , pp. 1437-1450
    • Rings, E.H.1    Boudreau, F.2    Taylor, J.K.3    Moffett, J.4    Suh, E.R.5    Traber, P.G.6
  • 46
    • 0037077248 scopus 로고    scopus 로고
    • Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha
    • Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, Reinecker HC. Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem 277: 21361-21370, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 21361-21370
    • Sakaguchi, T.1    Gu, X.2    Golden, H.M.3    Suh, E.4    Rhoads, D.B.5    Reinecker, H.C.6
  • 47
    • 8444220513 scopus 로고    scopus 로고
    • Signaling pathways in intestinal development and cancer
    • Sancho E, Batlle E, Clevers H. Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol 20: 695-723, 2004.
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 695-723
    • Sancho, E.1    Batlle, E.2    Clevers, H.3
  • 48
    • 25844464135 scopus 로고    scopus 로고
    • Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization
    • Satohisa S, Chiba H, Osanai M, Ohno S, Kojima T, Saito T, Sawada N. Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization. Exp Cell Res 310: 66-78, 2005.
    • (2005) Exp Cell Res , vol.310 , pp. 66-78
    • Satohisa, S.1    Chiba, H.2    Osanai, M.3    Ohno, S.4    Kojima, T.5    Saito, T.6    Sawada, N.7
  • 49
    • 0037072822 scopus 로고    scopus 로고
    • Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms
    • Sauvaget D, Chauffeton V, Citadelle D, Chatelet FP, Cywiner-Golenzer C, Chambaz J, Pincon-Raymond M, Cardot P, Le Beyec J, Ribeiro A. Restriction of apolipoprotein A-IV gene expression to the intestine villus depends on a hormone-responsive element and parallels differential expression of the hepatic nuclear factor 4alpha and gamma isoforms. J Biol Chem 277: 34540-34548, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 34540-34548
    • Sauvaget, D.1    Chauffeton, V.2    Citadelle, D.3    Chatelet, F.P.4    Cywiner-Golenzer, C.5    Chambaz, J.6    Pincon-Raymond, M.7    Cardot, P.8    Le Beyec, J.9    Ribeiro, A.10
  • 51
    • 0022976461 scopus 로고
    • Immunocytochemical localization of extracellular-matrix proteins in relation to rat intestinal morphogenesis
    • Simon-Assmann P, Kedinger M, Haffen K. Immunocytochemical localization of extracellular-matrix proteins in relation to rat intestinal morphogenesis. Differentiation 32: 59-66, 1986.
    • (1986) Differentiation , vol.32 , pp. 59-66
    • Simon-Assmann, P.1    Kedinger, M.2    Haffen, K.3
  • 52
    • 28444460226 scopus 로고    scopus 로고
    • C/EBP and Cdx family factors regulate liver fatty acid binding protein transgene expression in the small intestinal epithelium
    • Staloch LJ, Divine JK, Witten JT, Simon TC. C/EBP and Cdx family factors regulate liver fatty acid binding protein transgene expression in the small intestinal epithelium. Biochim Biophys Acta 1731: 168-178, 2005.
    • (2005) Biochim Biophys Acta , vol.1731 , pp. 168-178
    • Staloch, L.J.1    Divine, J.K.2    Witten, J.T.3    Simon, T.C.4
  • 54
    • 0030032310 scopus 로고    scopus 로고
    • An intestine-specific homeobox gene regulates proliferation and differentiation
    • Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 16: 619-625, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 619-625
    • Suh, E.1    Traber, P.G.2
  • 58
    • 0036930731 scopus 로고    scopus 로고
    • Novel interaction at the Cdx-2 binding sites of the lactase-phlorizin hydrolase promoter
    • Van Wering HM, Moyer L, Grand RJ, Krasinski SD. Novel interaction at the Cdx-2 binding sites of the lactase-phlorizin hydrolase promoter. Biochem Biophys Res Commun 299: 587-593, 2002.
    • (2002) Biochem Biophys Res Commun , vol.299 , pp. 587-593
    • Van Wering, H.M.1    Moyer, L.2    Grand, R.J.3    Krasinski, S.D.4
  • 59
    • 14644428982 scopus 로고    scopus 로고
    • Recent findings in the cell and molecular biology of the small intestine
    • Walters JR. Recent findings in the cell and molecular biology of the small intestine. Curr Opin Gastroenterol 21: 135-140, 2005.
    • (2005) Curr Opin Gastroenterol , vol.21 , pp. 135-140
    • Walters, J.R.1
  • 61
    • 0038241793 scopus 로고    scopus 로고
    • HNF4: A central regulator of hepatocyte differentiation and function
    • Watt AJ, Garrison WD, Duncan SA. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology 37: 1249-1253, 2003.
    • (2003) Hepatology , vol.37 , pp. 1249-1253
    • Watt, A.J.1    Garrison, W.D.2    Duncan, S.A.3
  • 62
    • 0032873240 scopus 로고    scopus 로고
    • Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans
    • Whitehead RH, Demmler K, Rockman SP, Watson NK. Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans. Gastroenterology 117: 858-865, 1999.
    • (1999) Gastroenterology , vol.117 , pp. 858-865
    • Whitehead, R.H.1    Demmler, K.2    Rockman, S.P.3    Watson, N.K.4
  • 63
    • 23244432429 scopus 로고    scopus 로고
    • BMP signaling and stem cell regulation
    • Zhang J, Li L. BMP signaling and stem cell regulation. Dev Biol 284: 1-11, 2005.
    • (2005) Dev Biol , vol.284 , pp. 1-11
    • Zhang, J.1    Li, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.