메뉴 건너뛰기




Volumn 20, Issue 9, 2010, Pages 525-531

Effects of the CYP3A5*3 variant on cyclosporine exposure and acute rejection rate in renal transplant patients: A meta-analysis

Author keywords

cyclosporine; CYP3A5; kidney transplantation; meta analysis P glycoprotein; pharmacogenetics; pharmacogenomics

Indexed keywords

CYCLOSPORIN A; CYTOCHROME P450 3A5; CYCLOSPORIN; CYP3A5 PROTEIN, HUMAN; CYTOCHROME P450 3A;

EID: 77955926766     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32833ccd56     Document Type: Article
Times cited : (34)

References (49)
  • 1
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • Kronbach T, Fischer V, Meyer UA. Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 1988; 43:630-635.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 2
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK506
    • Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T. Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 1993; 268:6077-6080.
    • (1993) J Biol Chem , vol.268 , pp. 6077-6080
    • Saeki, T.1    Ueda, K.2    Tanigawara, Y.3    Hori, R.4    Komano, T.5
  • 3
    • 0343416856 scopus 로고    scopus 로고
    • Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery
    • Hebert MF. Contributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug delivery. Adv Drug Deliv Rev 1997; 27:201-214.
    • (1997) Adv Drug Deliv Rev , vol.27 , pp. 201-214
    • Hebert, M.F.1
  • 5
    • 77951091354 scopus 로고    scopus 로고
    • Personalized immunosuppressive therapy in pediatric heart transplantation: Progress, pitfalls and promises
    • Xie HG. Personalized immunosuppressive therapy in pediatric heart transplantation: progress, pitfalls and promises. Pharmacol Ther 2010; 126:146-158.
    • (2010) Pharmacol Ther , vol.126 , pp. 146-158
    • Xie, H.G.1
  • 6
    • 0035238531 scopus 로고    scopus 로고
    • Cyclosporin: An updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral) 1 in organ transplantation
    • Dunn CJ, Wagstaff AJ, Perry CM, Plosker GL, Goa KL. Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral) 1 in organ transplantation. Drugs 2001; 61:1957-2016.
    • (2001) Drugs , vol.61 , pp. 1957-2016
    • Dunn, C.J.1    Wagstaff, A.J.2    Perry, C.M.3    Plosker, G.L.4    Goa, K.L.5
  • 7
    • 0033565808 scopus 로고    scopus 로고
    • Neoral monitoring by simplified sparse sampling area under the concentration-time curve
    • Mahalati K, Belitsky P, Sketris I, West K, Panek R. Neoral monitoring by simplified sparse sampling area under the concentration-time curve. Transplantation 1999; 68:55-62.
    • (1999) Transplantation , vol.68 , pp. 55-62
    • Mahalati, K.1    Belitsky, P.2    Sketris, I.3    West, K.4    Panek, R.5
  • 8
    • 0036208713 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of immunosuppressant drugs in clinical practice
    • 329
    • Kahan BD, Keown P, Levy GA, Johnston A. Therapeutic drug monitoring of immunosuppressant drugs in clinical practice. Clin Ther 2002; 24:330-350. 329.
    • (2002) Clin Ther , vol.24 , pp. 330-350
    • Kahan, B.D.1    Keown, P.2    Levy, G.A.3    Johnston, A.4
  • 9
    • 0036860975 scopus 로고    scopus 로고
    • New concepts in cyclosporine monitoring
    • Keown PA. New concepts in cyclosporine monitoring. Curr Opin Nephrol Hypertens 2002; 11:619-629.
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 619-629
    • Keown, P.A.1
  • 11
    • 0035054725 scopus 로고    scopus 로고
    • The gut as a barrier to drug absorption: Combined role of cytochrome P450 3A and P-glycoprotein
    • Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clin Pharmacokinet 2001; 40:159-168.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 159-168
    • Zhang, Y.1    Benet, L.Z.2
  • 12
    • 0036219998 scopus 로고    scopus 로고
    • Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
    • Lamba JK, Lin YS, Thummel K, Daly A, Watkins PB, Strom S, et al. Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics 2002; 12:121-132.
    • (2002) Pharmacogenetics , vol.12 , pp. 121-132
    • Lamba, J.K.1    Lin, Y.S.2    Thummel, K.3    Daly, A.4    Watkins, P.B.5    Strom, S.6
  • 13
  • 14
    • 16544365185 scopus 로고    scopus 로고
    • Genetics of the variable expression of CYP3A in humans
    • Wojnowski L. Genetics of the variable expression of CYP3A in humans. Ther Drug Monit 2004; 26:192-199.
    • (2004) Ther Drug Monit , vol.26 , pp. 192-199
    • Wojnowski, L.1
  • 15
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y, Lamba J, Assem MS, Chuetz J, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001; 27:383-391.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3    Lamba, J.4    Assem, M.S.5    Chuetz, J.6
  • 18
    • 0036089341 scopus 로고    scopus 로고
    • Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism
    • Lin YS, Dowling AL, Quigley SD, Farin FM, Zhang J, Lamba J, et al. Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism. Mol Pharmacol 2002; 62:162-172.
    • (2002) Mol Pharmacol , vol.62 , pp. 162-172
    • Lin, Y.S.1    Dowling, A.L.2    Quigley, S.D.3    Farin, F.M.4    Zhang, J.5    Lamba, J.6
  • 19
    • 0037131879 scopus 로고    scopus 로고
    • Genetic contribution to variable human CYP3A-mediated metabolism
    • Lamba JK, Lin YS, Shuetz EG, Thummel KE. Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev 2002; 54:1271-1294.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1271-1294
    • Lamba, J.K.1    Lin, Y.S.2    Shuetz, E.G.3    Thummel, K.E.4
  • 21
    • 33845232219 scopus 로고    scopus 로고
    • Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors
    • Utecht KN, Hiles JJ, Kolesar J. Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors. Am J Health Syst Pharm 2006; 63:2340-2348.
    • (2006) Am J Health Syst Pharm , vol.63 , pp. 2340-2348
    • Utecht, K.N.1    Hiles, J.J.2    Kolesar, J.3
  • 22
    • 1442283062 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population
    • Saeki M, Saito Y, Nakamura T, Murayama N, Kim SR, Ozawa S, et al. Single nucleotide polymorphisms and haplotype frequencies of CYP3A5 in a Japanese population. Hum Mutat 2003; 21:653-660.
    • (2003) Hum Mutat , vol.21 , pp. 653-660
    • Saeki, M.1    Saito, Y.2    Nakamura, T.3    Murayama, N.4    Kim, S.R.5    Ozawa, S.6
  • 23
    • 0027226147 scopus 로고
    • Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation
    • Lindholm A, Kahan BD. Influence of cyclosporine pharmacokinetics, trough concentrations, and AUC monitoring on outcome after kidney transplantation. Clin Pharmacol Ther 1993; 54:205-218.
    • (1993) Clin Pharmacol Ther , vol.54 , pp. 205-218
    • Lindholm, A.1    Kahan, B.D.2
  • 24
    • 0029789453 scopus 로고    scopus 로고
    • Variable oral absorption of cyclosporine A biopharmaceutical risk factor for chronic renal allograft rejection
    • Kahan BD, Welsh M, Schoenberg L, Rutzky LP, Katz SM, Urbauer DL, et al. Variable oral absorption of cyclosporine. A biopharmaceutical risk factor for chronic renal allograft rejection. Transplantation 1996; 62:599-606.
    • (1996) Transplantation , vol.62 , pp. 599-606
    • Kahan, B.D.1    Welsh, M.2    Schoenberg, L.3    Rutzky, L.P.4    Katz, S.M.5    Urbauer, D.L.6
  • 25
    • 0036766650 scopus 로고    scopus 로고
    • Adequate early cyclosporin exposure is critical to prevent allograft rejection: Patients monitored by absorption profiling
    • Clase CM, Mahalati K, Kiberd BA, Lawen JG, West KA, Fraser AD, et al. Adequate early cyclosporin exposure is critical to prevent allograft rejection: patients monitored by absorption profiling. Am J Transplant 2002; 2:789-795.
    • (2002) Am J Transplant , vol.2 , pp. 789-795
    • Clase, C.M.1    Mahalati, K.2    Kiberd, B.A.3    Lawen, J.G.4    West, K.A.5    Fraser, A.D.6
  • 26
    • 0041831261 scopus 로고    scopus 로고
    • Genetic polymorphisms of the CYP3A4 CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
    • Hesselink DA, van Schaik RH, van der Heiden IP, van der Werf M, Gregoor PJ, Lindemans J, et al. Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus. Clin Pharmacol Ther 2003; 74:245-254.
    • (2003) Clin Pharmacol Ther , vol.74 , pp. 245-254
    • Hesselink, D.A.1    Van Schaik, R.H.2    Van Der Heiden, I.P.3    Van Der Werf, M.4    Gregoor, P.J.5    Lindemans, J.6
  • 27
    • 11144358432 scopus 로고    scopus 로고
    • CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation
    • Anglicheau D, Thervet E, Etienne I, Hurault DLB, Le Meur Y, Touchard G, et al. CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation. Clin Pharmacol Ther 2004; 75:422-433.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 422-433
    • Anglicheau, D.1    Thervet, E.2    Etienne, I.3    Dlb, H.4    Le Meur, Y.5    Touchard, G.6
  • 28
    • 12144286933 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients
    • Haufroid V, Mourad M, Van Kerckhove V, Wawrzyniak J, De Meyer M, Eddour DC, et al. The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenetics 2004; 14:147-154.
    • (2004) Pharmacogenetics , vol.14 , pp. 147-154
    • Haufroid, V.1    Mourad, M.2    Van Kerckhove, V.3    Wawrzyniak, J.4    De Meyer, M.5    Eddour, D.C.6
  • 29
    • 6944230851 scopus 로고    scopus 로고
    • The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients
    • Kreutz R, Zurcher H, Kain S, Martus P, Offermann G, Beige J. The effect of variable CYP3A5 expression on cyclosporine dosing, blood pressure and long-term graft survival in renal transplant patients. Pharmacogenetics 2004; 14:665-671.
    • (2004) Pharmacogenetics , vol.14 , pp. 665-671
    • Kreutz, R.1    Zurcher, H.2    Kain, S.3    Martus, P.4    Offermann, G.5    Beige, J.6
  • 30
    • 16244419058 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus
    • Zhao Y, Song M, Guan D, Bi S, Meng J, Li Q, et al. Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus. Transplant Proc 2005; 37:178-181.
    • (2005) Transplant Proc , vol.37 , pp. 178-181
    • Zhao, Y.1    Song, M.2    Guan, D.3    Bi, S.4    Meng, J.5    Li, Q.6
  • 31
    • 33750344807 scopus 로고    scopus 로고
    • Influence of CYP3A5 genetic polymorphism on cyclosporine A metabolism and elimination in Chinese renal transplant recipients
    • Chu XM, Hao HP,Wang GJ, Guo LQ, Min PQ. Influence of CYP3A5 genetic polymorphism on cyclosporine A metabolism and elimination in Chinese renal transplant recipients. Acta Pharmacol Sin 2006; 27:1504-1508.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 1504-1508
    • Chu, X.M.1    Hao Hpwang, G.J.2    Guo, L.Q.3    Min, P.Q.4
  • 32
    • 33750038835 scopus 로고    scopus 로고
    • Effects of genetic polymorphisms of CYP3A4 CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation
    • Hu YF, Qiu W, Liu ZQ, Zhu LJ, Liu ZQ, Tu JH, et al. Effects of genetic polymorphisms of CYP3A4, CYP3A5 and MDR1 on cyclosporine pharmacokinetics after renal transplantation. Clin Exp Pharmacol Physiol 2006; 33:1093-1098.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 1093-1098
    • Hu, Y.F.1    Qiu, W.2    Liu, Z.Q.3    Zhu, L.J.4    Liu, Z.Q.5    Tu, J.H.6
  • 33
    • 33947722588 scopus 로고    scopus 로고
    • Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements
    • Fredericks S, Jorga A, MacPhee IA, Reboux S, Shiferaw E, Moreton M, et al. Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements. Clin Transplant 2007; 21:252-257.
    • (2007) Clin Transplant , vol.21 , pp. 252-257
    • Fredericks, S.1    Jorga, A.2    MacPhee, I.A.3    Reboux, S.4    Shiferaw, E.5    Moreton, M.6
  • 34
    • 33646681672 scopus 로고    scopus 로고
    • The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients
    • Eng HS, Mohamed Z, Calne R, Lang CC, Mohd MA, Seet WT, et al. The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients. Kidney Int 2006; 69:1858-1864.
    • (2006) Kidney Int , vol.69 , pp. 1858-1864
    • Eng, H.S.1    Mohamed, Z.2    Calne, R.3    Lang, C.C.4    Mohd, M.A.5    Seet, W.T.6
  • 35
    • 45449099489 scopus 로고    scopus 로고
    • Significant impact of gene polymorphisms on tacrolimus but not cyclosporine dosing in Asian renal transplant recipients
    • Loh PT, Lou HX, Zhao Y, Chin YM, Vathsala A. Significant impact of gene polymorphisms on tacrolimus but not cyclosporine dosing in Asian renal transplant recipients. Transplant Proc 2008; 40:1690-1695.
    • (2008) Transplant Proc , vol.40 , pp. 1690-1695
    • Loh, P.T.1    Lou, H.X.2    Zhao, Y.3    Chin, Y.M.4    Vathsala, A.5
  • 36
    • 55349128503 scopus 로고    scopus 로고
    • Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients
    • Qiu XY, Jiao Z, Zhang M, Zhong LJ, Liang HQ, Ma CL, et al. Association of MDR1, CYP3A4*18B, and CYP3A5*3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients. Eur J Clin Pharmacol 2008; 64:1069-1084.
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 1069-1084
    • Qiu, X.Y.1    Jiao, Z.2    Zhang, M.3    Zhong, L.J.4    Liang, H.Q.5    Ma, C.L.6
  • 37
    • 70849094684 scopus 로고    scopus 로고
    • Influence of the MDR1 haplotype and CYP3A5 genotypes on cyclosporine blood level in Chinese renal transplant recipients
    • Chen B, Zhang W, Fang J, Jin Z, Li J, Yu Z, Cai W. Influence of the MDR1 haplotype and CYP3A5 genotypes on cyclosporine blood level in Chinese renal transplant recipients. Xenobiotica 2009; 39:931-938.
    • (2009) Xenobiotica , vol.39 , pp. 931-938
    • Chen, B.1    Zhang, W.2    Fang, J.3    Jin, Z.4    Li, J.5    Yu, Z.6    Cai, W.7
  • 38
    • 60549093838 scopus 로고    scopus 로고
    • Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem
    • Wang Y, Wang C, Li J, Wang X, Zhu G, Chen X, et al. Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem. Eur J Clin Pharmacol 2009; 65:239-247.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 239-247
    • Wang, Y.1    Wang, C.2    Li, J.3    Wang, X.4    Zhu, G.5    Chen, X.6
  • 39
    • 67449141674 scopus 로고    scopus 로고
    • Impact of CYP3A5 and CYP3A4 gene polymorphisms on dose requirement of calcineurin inhibitors, cyclosporine and tacrolimus, in renal allograft recipients of North India
    • Singh R, Srivastava A, Kapoor R, Sharma KR, Mittal DR. Impact of CYP3A5 and CYP3A4 gene polymorphisms on dose requirement of calcineurin inhibitors, cyclosporine and tacrolimus, in renal allograft recipients of North India. Naunyn Schmiedebergs Arch Pharmaco 2009; 380:169-177.
    • (2009) Naunyn Schmiedebergs Arch Pharmaco , vol.380 , pp. 169-177
    • Singh, R.1    Srivastava, A.2    Kapoor, R.3    Sharma, K.R.4    Mittal, D.R.5
  • 40
    • 0037906108 scopus 로고    scopus 로고
    • The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients
    • Yates CR, Zhang WH, Song PF, Li S, Gaber AO, Kotb M, et al. The effect of CYP3A5 and MDR1 polymorphic expression on cyclosporine oral disposition in renal transplant patients. J Clin Pharmacol 2003; 43:555-564.
    • (2003) J Clin Pharmacol , vol.43 , pp. 555-564
    • Yates, C.R.1    Zhang, W.H.2    Song, P.F.3    Li, S.4    Gaber, A.O.5    Kotb, M.6
  • 41
    • 0033725192 scopus 로고    scopus 로고
    • Gender-dependent racial difference in disposition of cyclosporine among healthy African American and white volunteers
    • Min DI, Lee M, Ku Y, Flanigan M. Gender-dependent racial difference in disposition of cyclosporine among healthy African American and white volunteers. Clin Pharmacol Ther 2000; 68:478-486.
    • (2000) Clin Pharmacol Ther , vol.68 , pp. 478-486
    • Min, D.I.1    Lee, M.2    Ku, Y.3    Flanigan, M.4
  • 42
    • 23044491475 scopus 로고    scopus 로고
    • Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression
    • Chowbay B, Li HH, David M, Cheung YB, Lee EJ. Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression. Br J Clin Pharmacol 2004; 60:159-171.
    • (2004) Br J Clin Pharmacol , vol.60 , pp. 159-171
    • Chowbay, B.1    Li, H.H.2    David, M.3    Cheung, Y.B.4    Lee, E.J.5
  • 43
    • 22344432565 scopus 로고    scopus 로고
    • Contribution of genetic polymorphisms of the CYP3A4 CYP3A5 and MDR1 genes to cyclosporine disposition
    • Hu YF, Zhou HH. Contribution of genetic polymorphisms of the CYP3A4, CYP3A5 and MDR1 genes to cyclosporine disposition. Chinese Pharmacol Bull 2005; 21:257-261.
    • (2005) Chinese Pharmacol Bull , vol.21 , pp. 257-261
    • Hu, Y.F.1    Zhou, H.H.2
  • 44
    • 42049122605 scopus 로고    scopus 로고
    • Role of pharmacogenetics of immunosuppressive drugs in organ transplantation
    • Thervet E, Anglicheau D, Legendre C, Beaune P. Role of pharmacogenetics of immunosuppressive drugs in organ transplantation. Ther Drug Monit 2008; 30:143-150.
    • (2008) Ther Drug Monit , vol.30 , pp. 143-150
    • Thervet, E.1    Anglicheau, D.2    Legendre, C.3    Beaune, P.4
  • 45
    • 0026488174 scopus 로고
    • Demographic factors influencing cyclosporine pharmacokinetics parameters in patients with uremia: Racial differences in bioavailability
    • Lindholm A, Welsh M, Alton C, Kahan BD. Demographic factors influencing cyclosporine pharmacokinetics parameters in patients with uremia: racial differences in bioavailability. Clin Pharmacol Ther 1992; 52:359-371.
    • (1992) Clin Pharmacol Ther , vol.52 , pp. 359-371
    • Lindholm, A.1    Welsh, M.2    Alton, C.3    Kahan, B.D.4
  • 46
    • 0029868808 scopus 로고    scopus 로고
    • Cyclosporine bioavailability: Dosing implications and impact on clinical outcomes in select transplantation subpopulations
    • First MR, Schroeder TJ, Monaco AP, Simpson MA, Curtis JJ, Armenti VT. Cyclosporine bioavailability: dosing implications and impact on clinical outcomes in select transplantation subpopulations. Clin Transplant 1996; 10:55-59.
    • (1996) Clin Transplant , vol.10 , pp. 55-59
    • First, M.R.1    Schroeder, T.J.2    Monaco, A.P.3    Simpson, M.A.4    Curtis, J.J.5    Armenti, V.T.6
  • 47
    • 10044294681 scopus 로고    scopus 로고
    • Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1 CYP3A4, and CYP3A5 genes
    • Hesselink DA, Van Gelder T, Van Schaik RHN, Balk AH, van der Heiden IP, van Dam T, et al. Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes. Clin Pharmacol Ther 2004; 76:545-556.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 545-556
    • Hesselink, D.A.1    Van Gelder, T.2    Van Schaik Rhn3    Balk, A.H.4    Van Der Heiden, I.P.5    Van Dam, T.6
  • 48
    • 77955924215 scopus 로고    scopus 로고
    • Meta-analysis of the effect of MDRI C3435T polymorphism on cyclosporine pharmacokinetic
    • Jiang ZP, Wang YR, Xu P, Liu RR, Zhao XL, Chen FP, et al. Meta-analysis of the effect of MDRI C3435T polymorphism on cyclosporine pharmacokinetic. Central South Pharmacy 2008; 6:111-116.
    • (2008) Central South Pharmacy , vol.6 , pp. 111-116
    • Jiang, Z.P.1    Wang, Y.R.2    Xu, P.3    Liu, R.R.4    Zhao, X.L.5    Chen, F.P.6
  • 49
    • 13844315559 scopus 로고    scopus 로고
    • CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet systematic review and meta-analysis
    • Sanderson S, Emery J, Higgins J. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. Genet Med 2005; 7:97-104.
    • (2005) Genet Med , vol.7 , pp. 97-104
    • Sanderson, S.1    Emery, J.2    Higgins, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.