메뉴 건너뛰기




Volumn 170, Issue 1, 2010, Pages 289-297

Granins as disease-biomarkers: Translational potential for psychiatric and neurological disorders

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; Chromogranin; Schizophrenia; Secretogranin; VGF

Indexed keywords

ACID PROTEIN; BIOLOGICAL MARKER; CELL PROTEIN; CHROMOGRANIN A; CHROMOGRANIN B; GRANIN; HISL 19 ANTIGEN; PROTEIN NESP55; PROTEIN PROSAAS; PROTEIN VGF; SECRETOGRANIN II; SECRETOGRANIN III; SECRETOGRANIN V; UNCLASSIFIED DRUG;

EID: 77955924374     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.06.057     Document Type: Review
Times cited : (54)

References (79)
  • 1
    • 0013840826 scopus 로고
    • The release of protein from the stimulated adrenal medulla
    • Banks P., Helle K.B. The release of protein from the stimulated adrenal medulla. Biochem J 1965, 97:40C-41C.
    • (1965) Biochem J , vol.97
    • Banks, P.1    Helle, K.B.2
  • 3
    • 38149097874 scopus 로고    scopus 로고
    • The role of the vgf gene and VGF-derived peptides in nutrition and metabolism
    • Bartolomucci A., Possenti R., Levi A., Pavone F., Moles A. The role of the vgf gene and VGF-derived peptides in nutrition and metabolism. Genes Nutr 2007, 2:169-180.
    • (2007) Genes Nutr , vol.2 , pp. 169-180
    • Bartolomucci, A.1    Possenti, R.2    Levi, A.3    Pavone, F.4    Moles, A.5
  • 4
    • 0023332890 scopus 로고
    • The primary structure of human secretogranin. I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region
    • Benedum U.M., Lamouroux A., Konecki D.S., Rosa P., Hille A., Baeuerle P.A., Frank R., Lottspeich F., Mallet J., Huttner W.B. The primary structure of human secretogranin. I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. EMBO J 1987, 6:1203-1211.
    • (1987) EMBO J , vol.6 , pp. 1203-1211
    • Benedum, U.M.1    Lamouroux, A.2    Konecki, D.S.3    Rosa, P.4    Hille, A.5    Baeuerle, P.A.6    Frank, R.7    Lottspeich, F.8    Mallet, J.9    Huttner, W.B.10
  • 5
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69:89-95. Biomarkers Definitions Working Group.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 6
    • 0028871458 scopus 로고
    • Chromogranin A in cerebrospinal fluid: a biochemical marker for synaptic degeneration in Alzheimer's disease?
    • Blennow K., Davidsson P., Wallin A., Ekman R. Chromogranin A in cerebrospinal fluid: a biochemical marker for synaptic degeneration in Alzheimer's disease?. Dementia 1995, 6:306-311.
    • (1995) Dementia , vol.6 , pp. 306-311
    • Blennow, K.1    Davidsson, P.2    Wallin, A.3    Ekman, R.4
  • 9
    • 78649909456 scopus 로고    scopus 로고
    • (in press) Granin-derived peptides as diagnostic and prognostic markers for endocrine tumors. Regul Pept, doi:10.1016/j.regpep.2009.11.013
    • Conlon JM (in press) Granin-derived peptides as diagnostic and prognostic markers for endocrine tumors. Regul Pept; doi:10.1016/j.regpep.2009.11.013.
    • Conlon, J.M.1
  • 10
    • 33846029499 scopus 로고    scopus 로고
    • Secretory granule biogenesis in sympathoadrenal cells: identification of a granulogenic determinant in the secretory prohormone chromogranin A
    • Courel M., Rodemer C., Nguyen S.T., Pance A., Jackson A.P., O'Connor D.T., Taupenot L. Secretory granule biogenesis in sympathoadrenal cells: identification of a granulogenic determinant in the secretory prohormone chromogranin A. J Biol Chem 2006, 281:38038-38051.
    • (2006) J Biol Chem , vol.281 , pp. 38038-38051
    • Courel, M.1    Rodemer, C.2    Nguyen, S.T.3    Pance, A.4    Jackson, A.P.5    O'Connor, D.T.6    Taupenot, L.7
  • 12
    • 0023662168 scopus 로고
    • Is chromogranin A a prohormone?
    • Eiden L. Is chromogranin A a prohormone?. Nature 1987, 325:301.
    • (1987) Nature , vol.325 , pp. 301
    • Eiden, L.1
  • 14
    • 0030248464 scopus 로고    scopus 로고
    • Vgf A neurotrophin-inducible gene expressed in neuroendocrine tissues
    • Ferri G.L., Possenti R. vgf A neurotrophin-inducible gene expressed in neuroendocrine tissues. Trends Endocrinol Metab 1996, 7:233-239.
    • (1996) Trends Endocrinol Metab , vol.7 , pp. 233-239
    • Ferri, G.L.1    Possenti, R.2
  • 15
    • 0029035081 scopus 로고
    • Secretogranin. II: molecular properties, regulation of biosynthesis and processing to the neuropeptide secretoneurin
    • Fischer-Colbrie R., Laslop A., Kirchmair R. Secretogranin. II: molecular properties, regulation of biosynthesis and processing to the neuropeptide secretoneurin. Prog Neurobiol 1995, 46:49-70.
    • (1995) Prog Neurobiol , vol.46 , pp. 49-70
    • Fischer-Colbrie, R.1    Laslop, A.2    Kirchmair, R.3
  • 19
    • 9644276789 scopus 로고    scopus 로고
    • The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects
    • Helle K.B. The granin family of uniquely acidic proteins of the diffuse neuroendocrine system: comparative and functional aspects. Biol Rev 2004, 79:769-794.
    • (2004) Biol Rev , vol.79 , pp. 769-794
    • Helle, K.B.1
  • 20
    • 72049131601 scopus 로고    scopus 로고
    • The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions
    • Helle K.B. The chromogranin A-derived peptides vasostatin-I and catestatin as regulatory peptides for cardiovascular functions. Cardiovasc Res 2010, 85:9-16.
    • (2010) Cardiovasc Res , vol.85 , pp. 9-16
    • Helle, K.B.1
  • 24
  • 25
    • 3042565404 scopus 로고    scopus 로고
    • Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population
    • Iijima Y., Inada T., Ohtsuki T., Senoo H., Nakatani M., Arinami T. Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population. Biol Psychiatry 2004, 56:10-17.
    • (2004) Biol Psychiatry , vol.56 , pp. 10-17
    • Iijima, Y.1    Inada, T.2    Ohtsuki, T.3    Senoo, H.4    Nakatani, M.5    Arinami, T.6
  • 27
    • 4444302117 scopus 로고    scopus 로고
    • Molecular genetics of late-onset Alzheimer's disease
    • Kamboh M.I. Molecular genetics of late-onset Alzheimer's disease. Ann Hum Genet 2004, 68:381-404.
    • (2004) Ann Hum Genet , vol.68 , pp. 381-404
    • Kamboh, M.I.1
  • 29
    • 0027466425 scopus 로고
    • Secretoneurin-a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin. II (chromogranin C)
    • Kirchmair R., Hogue-Angeletti R., Gutierrez J., Fischer-Colbrie R., Winkler H. Secretoneurin-a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin. II (chromogranin C). Neuroscience 1993, 53:359-365.
    • (1993) Neuroscience , vol.53 , pp. 359-365
    • Kirchmair, R.1    Hogue-Angeletti, R.2    Gutierrez, J.3    Fischer-Colbrie, R.4    Winkler, H.5
  • 30
    • 0034501092 scopus 로고    scopus 로고
    • A contribution to genome-wide association studies: search for susceptibility loci for schizophrenia using DNA microsatellite markers on chromosomes 19, 20, 21 and 22
    • Kitao Y., Inada T., Arinami T., Hirotsu C., Aoki S., Iijima Y., Yamauchi T., Yagi G. A contribution to genome-wide association studies: search for susceptibility loci for schizophrenia using DNA microsatellite markers on chromosomes 19, 20, 21 and 22. Psychiatr Genet 2000, 10:139-143.
    • (2000) Psychiatr Genet , vol.10 , pp. 139-143
    • Kitao, Y.1    Inada, T.2    Arinami, T.3    Hirotsu, C.4    Aoki, S.5    Iijima, Y.6    Yamauchi, T.7    Yagi, G.8
  • 31
    • 74749106434 scopus 로고    scopus 로고
    • Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis
    • Koshimizu H., Kim T., Cawley N.X., Loh Y.P. Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis. Regul Pept 2010, 160:153-159.
    • (2010) Regul Pept , vol.160 , pp. 153-159
    • Koshimizu, H.1    Kim, T.2    Cawley, N.X.3    Loh, Y.P.4
  • 32
    • 0033406678 scopus 로고    scopus 로고
    • Reduction of the small synaptic vesicle protein synaptophysin but not the large dense core chromogranins in the left thalamus of subjects with schizophrenia
    • Landén M., Davidsson P., Gottfries C.G., Grenfeldt B., Stridsberg M., Blennow K. Reduction of the small synaptic vesicle protein synaptophysin but not the large dense core chromogranins in the left thalamus of subjects with schizophrenia. Biol Psychiatry 1999, 46:1698-1702.
    • (1999) Biol Psychiatry , vol.46 , pp. 1698-1702
    • Landén, M.1    Davidsson, P.2    Gottfries, C.G.3    Grenfeldt, B.4    Stridsberg, M.5    Blennow, K.6
  • 36
    • 0021796469 scopus 로고
    • Molecular cloning of a gene sequence regulated by nerve growth factor
    • Levi A., Eldridge J.D., Paterson B.M. Molecular cloning of a gene sequence regulated by nerve growth factor. Science 1985, 229:393-395.
    • (1985) Science , vol.229 , pp. 393-395
    • Levi, A.1    Eldridge, J.D.2    Paterson, B.M.3
  • 37
    • 3342962565 scopus 로고    scopus 로고
    • Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor
    • Levi A., Ferri G.L., Watson E., Possenti R., Salton S.R. Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor. Cell Mol Neurobiol 2004, 24:517-533.
    • (2004) Cell Mol Neurobiol , vol.24 , pp. 517-533
    • Levi, A.1    Ferri, G.L.2    Watson, E.3    Possenti, R.4    Salton, S.R.5
  • 38
    • 0030803637 scopus 로고    scopus 로고
    • Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist
    • Mahata S.K., O'Connor D.T., Mahata M., Yoo S.H., Taupenot L., Wu H., Gill B.M., Parmer R.J. Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist. J Clin Invest 1997, 100:1623-1633.
    • (1997) J Clin Invest , vol.100 , pp. 1623-1633
    • Mahata, S.K.1    O'Connor, D.T.2    Mahata, M.3    Yoo, S.H.4    Taupenot, L.5    Wu, H.6    Gill, B.M.7    Parmer, R.J.8
  • 40
    • 36248944562 scopus 로고    scopus 로고
    • Cerebrospinal fluid concentrations of peptides derived from chromogranin B and secretogranin II are decreased in multiple sclerosis
    • Mattsson N., Rüetschi U., Podust V.N., Stridsberg M., Li S., Andersen O., Haghighi S., Blennow K., Zetterberg H. Cerebrospinal fluid concentrations of peptides derived from chromogranin B and secretogranin II are decreased in multiple sclerosis. J Neurochem 2007, 103:1932-1939.
    • (2007) J Neurochem , vol.103 , pp. 1932-1939
    • Mattsson, N.1    Rüetschi, U.2    Podust, V.N.3    Stridsberg, M.4    Li, S.5    Andersen, O.6    Haghighi, S.7    Blennow, K.8    Zetterberg, H.9
  • 41
    • 0029938598 scopus 로고    scopus 로고
    • CSF of neuroleptic-naive first-episode schizophrenic patients: levels of biogenic amines, substance P, and peptides derived from chromogranin A (GE-25) and secretogranin II (secretoneurin)
    • Miller C., Kirchmair R., Troger J., Saria A., Fleischhacker W.W., Fischer-Colbrie R., Benzer A., Winkler H. CSF of neuroleptic-naive first-episode schizophrenic patients: levels of biogenic amines, substance P, and peptides derived from chromogranin A (GE-25) and secretogranin II (secretoneurin). Biol Psychiatry 1996, 39:911-918.
    • (1996) Biol Psychiatry , vol.39 , pp. 911-918
    • Miller, C.1    Kirchmair, R.2    Troger, J.3    Saria, A.4    Fleischhacker, W.W.5    Fischer-Colbrie, R.6    Benzer, A.7    Winkler, H.8
  • 42
    • 58249123878 scopus 로고    scopus 로고
    • Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury
    • Moss A., Ingram R., Koch S., Theodorou A., Low L., Baccei M., Hathway G.J., Costigan M., Salton S.R., Fitzgerald M. Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury. Mol Pain 2008, 4:62.
    • (2008) Mol Pain , vol.4 , pp. 62
    • Moss, A.1    Ingram, R.2    Koch, S.3    Theodorou, A.4    Low, L.5    Baccei, M.6    Hathway, G.J.7    Costigan, M.8    Salton, S.R.9    Fitzgerald, M.10
  • 43
    • 0025779349 scopus 로고
    • Chromogranin A-like immunoreactive neurites are major constituents of senile plaques
    • Munoz D.G. Chromogranin A-like immunoreactive neurites are major constituents of senile plaques. Lab Invest 1991, 64:826-832.
    • (1991) Lab Invest , vol.64 , pp. 826-832
    • Munoz, D.G.1
  • 44
    • 0036843803 scopus 로고    scopus 로고
    • Reduction of chromogranin B-like immunoreactivity in distinct subregions of the hippocampus from individuals with schizophrenia
    • Nowakowski C., Kaufmann W.A., Adlassnig C., Maier H., Salimi K., Jellinger K.A., Marksteiner J. Reduction of chromogranin B-like immunoreactivity in distinct subregions of the hippocampus from individuals with schizophrenia. Schizophr Res 2002, 58:43-53.
    • (2002) Schizophr Res , vol.58 , pp. 43-53
    • Nowakowski, C.1    Kaufmann, W.A.2    Adlassnig, C.3    Maier, H.4    Salimi, K.5    Jellinger, K.A.6    Marksteiner, J.7
  • 45
    • 56349162973 scopus 로고    scopus 로고
    • Salivary chromogranin A: useful and quantitative biochemical marker of affective state in patients with amyotrophic lateral sclerosis
    • Obayashi K., Sato K., Shimazaki R., Ishikawa T., Goto K., Ueyama H., Mori T., Ando Y., Kumamoto T. Salivary chromogranin A: useful and quantitative biochemical marker of affective state in patients with amyotrophic lateral sclerosis. Intern Med 2008, 47:1875-1879.
    • (2008) Intern Med , vol.47 , pp. 1875-1879
    • Obayashi, K.1    Sato, K.2    Shimazaki, R.3    Ishikawa, T.4    Goto, K.5    Ueyama, H.6    Mori, T.7    Ando, Y.8    Kumamoto, T.9
  • 46
    • 0027246556 scopus 로고
    • Cerebrospinal fluid chromogranin A is unchanged in Alzheimer dementia
    • O'Connor D.T., Kailasam M.T., Thal L.J. Cerebrospinal fluid chromogranin A is unchanged in Alzheimer dementia. Neurobiol Aging 1993, 14:267-269.
    • (1993) Neurobiol Aging , vol.14 , pp. 267-269
    • O'Connor, D.T.1    Kailasam, M.T.2    Thal, L.J.3
  • 50
    • 0019511459 scopus 로고
    • Characterization of adenohypophysial polypeptides by two-dimensional gel electrophoresis: II. Sulfated and glycosylated polypeptides
    • Rosa P., Zanini A. Characterization of adenohypophysial polypeptides by two-dimensional gel electrophoresis: II. Sulfated and glycosylated polypeptides. Mol Cell Endocrinol 1981, 24:181-193.
    • (1981) Mol Cell Endocrinol , vol.24 , pp. 181-193
    • Rosa, P.1    Zanini, A.2
  • 53
    • 77949524158 scopus 로고    scopus 로고
    • Chromogranin A: a novel susceptibility gene for essential hypertension
    • Sahu B.S., Sonawane P.J., Mahapatra N.R. Chromogranin A: a novel susceptibility gene for essential hypertension. Cell Mol Life Sci 2010, 67:861-874.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 861-874
    • Sahu, B.S.1    Sonawane, P.J.2    Mahapatra, N.R.3
  • 55
    • 0026342227 scopus 로고
    • Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells
    • Salton S.R., Fischberg D.J., Dong K.W. Structure of the gene encoding VGF, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Mol Cell Biol 1991, 11:2335-2349.
    • (1991) Mol Cell Biol , vol.11 , pp. 2335-2349
    • Salton, S.R.1    Fischberg, D.J.2    Dong, K.W.3
  • 56
    • 0029065316 scopus 로고
    • Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis
    • Schiffer D., Cordera S., Giordana M.T., Attanasio A., Pezzulo T. Synaptic vesicle proteins, synaptophysin and chromogranin A in amyotrophic lateral sclerosis. J Neurol Sci 1995, 129:68-74.
    • (1995) J Neurol Sci , vol.129 , pp. 68-74
    • Schiffer, D.1    Cordera, S.2    Giordana, M.T.3    Attanasio, A.4    Pezzulo, T.5
  • 60
    • 0032571806 scopus 로고    scopus 로고
    • Expression of VGF mRNA in the adult rat central nervous system
    • Snyder S.E., Salton S.R. Expression of VGF mRNA in the adult rat central nervous system. J Comp Neurol 1998, 394:91-105.
    • (1998) J Comp Neurol , vol.394 , pp. 91-105
    • Snyder, S.E.1    Salton, S.R.2
  • 64
    • 65249180831 scopus 로고    scopus 로고
    • Quantitative matrix-assisted laser desorption ionization-fourier transform ion cyclotron resonance (MALDI-FT-ICR) peptide profiling and identification of multiple-sclerosis-related proteins
    • Stoop M.P., Dekker L.J., Titulaer M.K., Lamers R.J., Burgers P.C., Sillevis Smitt P.A., van Gool A.J., Luider T.M., Hintzen R.Q. Quantitative matrix-assisted laser desorption ionization-fourier transform ion cyclotron resonance (MALDI-FT-ICR) peptide profiling and identification of multiple-sclerosis-related proteins. J Proteome Res 2009, 8:1404-1414.
    • (2009) J Proteome Res , vol.8 , pp. 1404-1414
    • Stoop, M.P.1    Dekker, L.J.2    Titulaer, M.K.3    Lamers, R.J.4    Burgers, P.C.5    Sillevis Smitt, P.A.6    van Gool, A.J.7    Luider, T.M.8    Hintzen, R.Q.9
  • 68
    • 70349306996 scopus 로고    scopus 로고
    • Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF
    • Toshinai K., Nakazato M. Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF. Cell Mol Life Sci 2009, 66:1939-1945.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1939-1945
    • Toshinai, K.1    Nakazato, M.2
  • 71
    • 29444443348 scopus 로고    scopus 로고
    • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
    • Urushitani M., Sik A., Sakurai T., Nukina N., Takahashi R., Julien J.P. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat Neurosci 2006, 9:108-118.
    • (2006) Nat Neurosci , vol.9 , pp. 108-118
    • Urushitani, M.1    Sik, A.2    Sakurai, T.3    Nukina, N.4    Takahashi, R.5    Julien, J.P.6
  • 72
    • 0025721813 scopus 로고
    • CSF chromogranin A-like immunoreactivity in schizophrenia. Assessment of clinical and biochemical relationships
    • van Kammen D.P., Peters J., Yao J., Neylan T., Beuger M., Pontius E., O'Connor D.T. CSF chromogranin A-like immunoreactivity in schizophrenia. Assessment of clinical and biochemical relationships. Schizophr Res 1991, 6:31-39.
    • (1991) Schizophr Res , vol.6 , pp. 31-39
    • van Kammen, D.P.1    Peters, J.2    Yao, J.3    Neylan, T.4    Beuger, M.5    Pontius, E.6    O'Connor, D.T.7
  • 74
    • 0025327264 scopus 로고
    • A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease
    • Weiler R., Lassmann H., Fischer P., Jellinger K., Winkler H. A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease. FEBS Lett 1990, 263:337-339.
    • (1990) FEBS Lett , vol.263 , pp. 337-339
    • Weiler, R.1    Lassmann, H.2    Fischer, P.3    Jellinger, K.4    Winkler, H.5
  • 75
    • 0026680263 scopus 로고
    • The chromogranins A and B: the first 25 years and future perspectives
    • Winkler H., Fischer-Colbrie R. The chromogranins A and B: the first 25 years and future perspectives. Neuroscience 1992, 49:497-528.
    • (1992) Neuroscience , vol.49 , pp. 497-528
    • Winkler, H.1    Fischer-Colbrie, R.2
  • 76
    • 4043087917 scopus 로고    scopus 로고
    • Manserin, a novel peptide from secretogranin II in the neuroendocrine system
    • Yajima A., Ikeda M., Miyazaki K., Maeshima T., Narita N., Narita M. Manserin, a novel peptide from secretogranin II in the neuroendocrine system. Neuroreport 2004, 15:1755-1759.
    • (2004) Neuroreport , vol.15 , pp. 1755-1759
    • Yajima, A.1    Ikeda, M.2    Miyazaki, K.3    Maeshima, T.4    Narita, N.5    Narita, M.6
  • 78
    • 0028331317 scopus 로고
    • Expression of chromogranin A in lesions in the central nervous system from patients with neurological diseases
    • Yasuhara O., Kawamata T., Aimi Y., McGeer E.G., McGeer P.L. Expression of chromogranin A in lesions in the central nervous system from patients with neurological diseases. Neurosci Lett 1994, 170:13-16.
    • (1994) Neurosci Lett , vol.170 , pp. 13-16
    • Yasuhara, O.1    Kawamata, T.2    Aimi, Y.3    McGeer, E.G.4    McGeer, P.L.5
  • 79
    • 45849085395 scopus 로고    scopus 로고
    • Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis
    • Zhao Z., Lange D.J., Ho L., Bonini S., Shao B., Salton S.R., Thomas S., Pasinetti G.M. Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis. Int J Med Sci 2008, 5:92-99.
    • (2008) Int J Med Sci , vol.5 , pp. 92-99
    • Zhao, Z.1    Lange, D.J.2    Ho, L.3    Bonini, S.4    Shao, B.5    Salton, S.R.6    Thomas, S.7    Pasinetti, G.M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.