VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters

Endocrinology

Volumn 148, Issue 8, 2007, Pages 4044-4055

  Jethwa, Preeti H ^a   Warner, Amy ^a   Nilaweera, Kanishka N ^b   Brameld, John M ^c   Keyte, John W ^a   Carter, Wayne G ^a   Bolton, Neil ^a   Bruggraber, Michael ^a   Morgan, Peter J ^b   Barrett, Perry ^b   Ebling, Francis J P ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; AMINO ACID; MESSENGER RNA; NEUROPEPTIDE Y; PROTEIN; THREONYLLEUCYLGLUTAMINYLPROLINE 21; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; VGF PROTEIN;

ABDOMINAL FAT; ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL SCIENCE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CATABOLISM; CONTROLLED STUDY; ENERGY EXPENDITURE; FEEDING; FOOD INTAKE; GENE EXPRESSION; HYPOPHAGIA; MALE; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; SATIETY; SEASONAL VARIATION;

ANIMALS; BODY WEIGHT; CRICETINAE; EATING; ENERGY METABOLISM; FEEDING BEHAVIOR; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; MALE; NEUROPEPTIDES; ORGAN SIZE; OXYGEN CONSUMPTION; PEPTIDE FRAGMENTS; PHODOPUS;

EID: 34547094107     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0038     Document Type: Article

References (40)

1. Levi A, Eldridge JD, Paterson BM 1985 Molecular cloning of a gene sequence regulated by nerve growth factor. Science 229:393-395
2. van den Pol AN, Bina K, Decavel C, Ghosh P 1994 VGF expression in the brain. J Comp Neurol 347:455-469
3. van den Pol AN, Decavel C, Levi A, Paterson B 1989 Hypothalamic expression of a novel gene product, VGF: immunocytochemical analysis. J Neurosci 9:4122-4137
4. Snyder SE, Salton SR 1998 Expression of VGF mRNA in the adult rat central nervous system. J Comp Neurol 394:91-105
5. Snyder SE, Pintar JE, Salton SR 1998 Developmental expression of VGF mRNA in the prenatal and postnatal rat. J Comp Neurol 394:64-90
6. Snyder SE, Li J, Salton SR 1997 Comparison of VGF and trk mRNA distributions in the developing and adult rat nervous systems. Brain Res Mol Brain Res 49:307-311
7. Possenti R, Eldridge JD, Paterson BM, Grasso A, Levi A 1989 A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway. EMBO J 8:2217-2223
8. Trani E, Ciotti T, Rinaldi AM, Canu N, Ferri GL, Levi A, Possenti R 1995 Tissue-specific processing of the neuroendocrine protein VGF. J Neurochem 65:2441-2449
9. Trani E, Giorgi A, Canu N, Amadoro G, Rinaldi AM, Halban PA, Ferri GL, Possenti R, Schinina ME, Levi A 2002 Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor. J Neurochem 81:565-574
10. Possenti R, Rinaldi AM, Ferri GL, Borboni P, Trani E, Levi A 1999 Expression, processing, and secretion of the neuroendocrine VGF peptides by INS-1 cells. Endocrinology 140:3727-3735
11. Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SR 2002 VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 22:6929-6938
12. Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR 1999 Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 23:537-548
13. Schuhler S, Horan TL, Hastings MH, Mercer JG, Morgan PJ, Ebling FJ 2004 Feeding and behavioural effects of central administration of the melanocortin 3/4-R antagonist SHU9119 in obese and lean Siberian hamsters. Behav Brain Res 152:177-185
14. Schuhler S, Horan TL, Hastings MH, Mercer JG, Morgan PJ, Ebling FJ 2003 Decrease of food intake by MC4-R agonist MTII in Siberian hamsters in long and short photoperiods. Am J Physiol Regul Integr Comp Physiol 284:R227-R232
15. Schuhler S, Ebling FJ 2006 Role of melanocortin in the long-term regulation of energy balance: lessons from a seasonal model. Peptides 27:301-309
16. Mercer JG, Moar KM, Logie TJ, Findlay PA, Adam CL, Morgan PJ 2001 Seasonally inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters. Endocrinology 142:4173-4181
17. Rousseau K, Atcha Z, Cagampang FR, Le RP, Stirland JA, Ivanov TR, Ebling FJ, Klingenspor M, Loudon AS 2002 Photoperiodic regulation of leptin resistance in the seasonally breeding Siberian hamster (Phodopus sungorus). Endocrinology 143:3083-3095
18. Reddy AB, Cronin AS, Ford H, Ebling FJ 1999 Seasonal regulation of food intake and body weight in the male Siberian hamster: studies of hypothalamic orexin (hypocretin), neuropeptide Y (NPY) and pro-opiomelanocortin (POMC). Eur J Neurosci 11:3255-3264
19. Ebling FJ, Cronin AS 1998 Manipulations of glutamatergic (N-methyl-D-aspartate receptor) neurotransmission alter the rate of photoperiodically regulated sexual maturation in the male Siberian hamster. Biol Reprod 58:1-7
20. Bartness TJ, Hamilton JM, Wade GN, Goldman BD 1989 Regional differences in fat pad responses to short days in Siberian hamsters. Am J Physiol 257:R1533-R1540
21. Klingenspor M, Dickopp A, Heldmaier G, Klaus S 1996 Short photoperiod reduces leptin gene expression in white and brown adipose tissue of Djungarian hamsters. FEBS Lett 399:290-294
22. Mercer JG, Moar KM, Ross AW, Hoggard N, Morgan PJ 2000 Photoperiod regulates arcuate nucleus POMC, AGRP, and leptin receptor mRNA in Siberian hamster hypothalamus. Am J Physiol Regul Integr Comp Physiol 278:R271-R281
23. Mercer JG, Moar KM, Ross AW, Morgan PJ 2000 Regulation of leptin receptor, POMCand AGRP gene expression by photoperiod and food deprivation in the hypothalamic arcuate nucleus of the male Siberian hamster (Phodopus sungorus). Appetite 34:109-111
24. Barrett P, Ross AW, Balik A, Littlewood PA, Mercer JG, Moar KM, Sallmen T, Kaslin J, Panula P, Schuhler S, Ebling FJ, Ubeaud C, Morgan PJ 2005 Photoperiodic regulation of histamine H3 receptor and VGF messenger ribonucleic acid in the arcuate nucleus of the Siberian hamster. Endocrinology 146:1930-1939
25. Bartolomucci A, La Corte G, Possenti R, Locatelli V, Rigamonti AE, Torsello A, Bresciani E, Bulgarelli I, Rizzi R, Pavone F, D'Amato FR, Severini C, Mignogna G, Giorgi A, Schinina ME, Elia G, Brancia C, Ferri GL, Conti R, Ciani B, Pascucci T, Dell'omo G, Muller EE, Levi A, Moles A 2006 TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci USA 103:14584 -14589
26. Ebling FJ 1994 Photoperiodic differences during development in the dwarf hamsters Phodopus sungorus and Phodopus campbelli. Gen Comp Endocrinol 95:475-482
27. Steward CA, Horan TL, Schuhler S, Bennett GW, Ebling FJ 2003 Central administration of thyrotropin releasing hormone (TRH) and related peptides inhibits feeding behavior in the Siberian hamster. Neuroreport 14:687-691
28. Schuhler S, Warner A, Finney N, Bennett GW, Ebling FJ, Brameld JM 2007 TRH decreases feeding and increases body temperature, activity, and oxygen consumption in Siberian hamsters. J Neuroendocrinol 19:239-249
29. Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ 2005 Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters. J Neuroendocrinol 17:276-285
30. Halford JC, Wanninayake SC, Blundell JE 1998 Behavioral satiety sequence (BSS) for the diagnosis of drug action on food intake. Pharmacol Biochem Behav 61:159-168
31. Jones HN, Ashworth CJ, Page KR, McArdle HJ 2006 Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo). Am J Physiol Endocrinol Metab 291:E596-E603
32. Adam CL, Moar KM, Logie TJ, Ross AW, Barrett P, Morgan PJ, Mercer JG 2000 Photoperiod regulates growth, puberty and hypothalamic neuropeptide and receptor gene expression in female Siberian hamsters. Endocrinology 141:4349-4356
33. Commins SP, Watson PM, Padgett MA, Dudley A, Argyropoulos G, Gettys TW 1999 Induction of uncoupling protein expression in brown and white adipose tissue by leptin. Endocrinology 140:292-300
34. Bartness TJ, Elliott JA, Goldman BD 1989 Control of torpor and body weight patterns by a seasonal timer in Siberian hamsters. Am J Physiol 257:R142-R149
35. Watson E, Hahm S, Mizuno TM, Windsor J, Montgomery C, Scherer PE, Mobbs CV, Salton SR 2005 VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity. Endocrinology 146:5151-5163
36. Zhang JV, Ren PG, vsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ 2005 Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310:996-999
37. Salton SR, Ferri GL, Hahm S, Snyder SE, Wilson AJ, Possenti R, Levi A 2000 VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance. Front Neuroendocrinol 21:199-219
38. Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S 1998 Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72-76
39. Moffett M, Stanek L, Harley J, Rogge G, Asnicar M, Hsiung H, Kuhar M 2006 Studies of cocaine- and amphetamine-regulated transcript (CART) knockout mice. Peptides 27:2037-2045
40. Abbott CR, Rossi M, Wren AM, Murphy KG, Kennedy AR, Stanley SA, Zollner AN, Morgan DG, Morgan I, Ghatei MA, Small CJ, Bloom SR 2001 Evidence of an orexigenic role for cocaine- and amphetamine-regulated transcript after administration into discrete hypothalamic nuclei. Endocrinology 142:3457-3463