Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis

International Journal of Medical Sciences

Volumn 5, Issue 2, 2008, Pages 92-99

  Zhao, Zhong ^a,b   Lange, Dale J ^a,b   Ho, Lap ^a,b   Bonini, Sara ^a,b   Shao, Belinda ^a,b   Salton, Stephen R ^b   Thomas, Sunil ^a,b   Pasinetti, Giulio Maria ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

ALS; Biomarker; Disease progression; Excitotoxicity; SOD 1 mice; VGF

Indexed keywords

BIOLOGICAL MARKER; PROTEIN DERIVATIVE; VGF PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BRAIN NERVE CELL; CELL CULTURE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; EXCITOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; MUSCLE WEAKNESS; NONHUMAN; PATHOGENESIS; PROTEIN CONTENT; PROTEIN EXPRESSION; SPINAL CORD MOTONEURON; TRANSGENIC MOUSE;

EID: 45849085395     PISSN: None     EISSN: 14491907     Source Type: Journal    
DOI: 10.7150/ijms.5.92     Document Type: Article

References (32)

1. Pasinetti GM, Ungar LH, Lange DJ, Yemul S, Deng H, Yuan X, Brown RH, Cudkowicz ME, Newhall K, Peskind E, Marcus S, Ho L. Identification of potential CSF biomarkers in ALS. Neurology 2006; 66(8): 1218-1222.
2. Alder J, Thakker-Varia S, Bangasser DA, Kuroiwa M, Plummer MR, Shors TJ, Black IB. Brain-derived neurotrophic factor-induced gene expression reveals novel actions of Vgf in hippocampal synaptic plasticity. J Neurosci 2003; 23(34): 10800-10808.
3. Dupuis L, Oudart H, Rene F, Gonzalez de Aguilar JL, Loeffler JP. Evidence for defective energy homeostasis in amyotrophic lateral sclerosis: benefit of a high-energy diet in a transgenic mouse model. Proc Natl Acad Sci USA 2004; 101(30): 11159-11164.
4. Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR. (2005) A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide Vgf into the regulated secretory pathway. J Biol Chem 2005; 280(50): 41595-41608.
5. Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR. Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron 1999; 23(3): 537-548.
6. Hahm S, Fekete C, Mizuno TM, Windsor J, Yan H, Boozer CN, Lee C, Elmquist JK, Lechan RM, Mobbs CV, Salton SR. VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci 2002; 22(16): 6929-6938.
7. Hawley RJ, Scheibe RJ, Wagner JA. NGF induces the expression of the Vgf gene through a cAMP response element. J Neurosci 1992; 12(7): 2573-2581.
8. Levi A, Eldridge JD, Paterson BM. Molecular cloning of a gene sequence regulated by nerve growth factor. Science 1985; 229(4711): 393-395.
9. Salton SR, Fischberg DJ, Dong KW. Structure of the gene encoding Vgf, a nervous system-specific mRNA that is rapidly and selectively induced by nerve growth factor in PC12 cells. Mol Cell Biol 1991; 11(5): 2335-2349.
10. Snyder SE, Salton SR. Expression of Vgf mRNA in the adult rat central nervous system. J Comp Neurol 1998; 394(1): 91-105.
11. Snyder SE, Pintar JE, Salton SR. Developmental expression of Vgf mRNA in the prenatal and postnatal rat. J Comp Neurol 1998; 394(1): 64-90.
12. van den Pol AN, Decavel C, Levi A, Paterson B. Hypothalamic expression of a novel gene product, Vgf: immunocytochemical analysis. J Neurosci 1989; 9(12): 4122-4137.
13. van den Pol AN, Bina K, Decavel C, Ghosh P. Vgf expression in the brain. J Comp Neurol 1994; 347(3): 455-469.
14. Jethwa PH, Warner A, Nilaweera KN, Brameld JM, Keyte JW, Carter WG, Bolton N, Bruggraber M, Morgan PJ, Barrett P, Ebling FJ. VGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters. Endocrinology 2007; 148(8): 4044-4055.
15. Bartolomucci A, La Corte G, Possenti R, Locatelli V, Rigamonti AE, Torsello A, Bresciani E, Bulgarelli I, Rizzi R, Pavone F, D'Amato FR, Severini C, Mignogna G, Giorgi A, Schinina ME, Elia G, Brancia C, Ferri GL, Conti R, Ciani B, Pascucci T, Dell'Omo G, Muller EE, Levi A, Moles A. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci USA 2006; 103(39): 14584-14589.
16. Yamaguchi H, Sasaki K, Satomi Y, Shimbara T, Kageyama H, Mondal MS, Toshinai K, Date Y, Gonzalez LJ, Shioda S, Takao T, Nakazato M, Minamino N. Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2. J Biol Chem 2007; 282(36): 26354-26360.
17. Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. Antidepressant actions of the exercise-regulated gene VGF. Nat Med 2007; 13(12): 1476-1482.
18. Brooks BR, Miller RG, Swash M, Munsat TL. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1(5): 293-299.
19. Salton SR, Volonte C, D'Arcangelo G. Stimulation of vgf gene expression by NGF is mediated through multiple signal transduction pathways involving protein phosphorylation. FEBS Lett 1995; 360(2): 106-110.
20. Pompl PN, Ho L, Bianchi M, McManus T, Qin W, Pasinetti GM. A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. FASEB J 2003; 17(6): 725-727.
21. Zhao Z, Lange DJ, Voustianiouk A, Macgrogan D, Ho L, Suh J, Humala N, Thiyagarajan M, Wang J, Pasinetti GM. A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis. BMC Neurosci 2006; 7: 29.
22. Chakraborty TR, Tkalych O, Nanno D, Garcia AL, Devi LA, Salton SR. Quantification of Vgf- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress. Brain Res 2006; 1089(1): 21-32.
23. Nyberg-Hoffman C, Shabram P, Li W, Giroux D, Aguilar-Cordova E. Sensitivity and reproducibility in adenoviral infectious titer determination. Nat Med 1997; 3(7): 808-811.
24. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2): 55-63.
25. Desport JC, Preux PM, Magy L, Boirie Y, Vallat JM, Beaufrere B, Couratier P. Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis. Am J Clin Nutr 2001; 74(3): 328-334.
26. Kong J, Xu Z. Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci 1998; 18(9): 3241-3250.
27. Mattiazzi M, D'Aurelio M, Gajewski CD, Martushova K, Kiaei M, Beal MF, Manfredi G. Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J Biol Chem 2002; 277(33): 29626-29633.
28. Menzies FM, Ince PG, Shaw PJ. Mitochondrial involvement in amyotrophic lateral sclerosis. Neurochem Int 2002; 40(6): 543-551.
29. Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH Jr. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 2004; 43(1):19-30.
30. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995; 14(6): 1105-1116.
31. Levi A, Ferri GL, Watson E, Possenti R, Salton SR. Processing, distribution, and function of Vgf, a neuronal and endocrine peptide precursor. Cell Mol Neurobiol 2004; 24(4): 517-533.
32. Salton SR, Ferri GL, Hahm S, Snyder SE, Wilson AJ, Possenti R, Levi A. Vgf: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance. Front Neuroendocrinol 2000; 21(3): 199-219.