Synthesis and binding affinities of Re(I) and 99mTc(I)- containing 16α-substituted estradiol complexes: Models for potential breast cancer imaging agents
ARTICLE;
BINDING AFFINITY;
BREAST CANCER;
CARBON NUCLEAR MAGNETIC RESONANCE;
DRUG RECEPTOR BINDING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
HUMAN;
INFRARED SPECTROSCOPY;
ANIMALS;
BINDING, COMPETITIVE;
BREAST NEOPLASMS;
CATTLE;
DIAGNOSTIC IMAGING;
ESTRADIOL;
ESTROGEN RECEPTOR ALPHA;
ESTROGEN RECEPTOR BETA;
HUMANS;
HYDROPHOBIC AND HYDROPHILIC INTERACTIONS;
ORGANOTECHNETIUM COMPOUNDS;
PROTEIN BINDING;
RHENIUM;
11β-Methoxy-, 11β-ethyl, and 17α-ethynyl-substituted 16α-fluoroestradiols: Receptor-based imaging agents with enhanced uptake efficiency and selectivity
M.G. Pomper, H. VanBrocklin, A. Thieme, R.D. Thomas, D.O. Kiesewetter, and K.E. Carlson 11β-Methoxy-, 11β-ethyl, and 17α-ethynyl- substituted 16α-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity J Med Chem 33 1990 3143 3155
18F]fluoronor-hexestrol), a positron-emitting estrogen that shows highly-selective, receptor-mediated uptake by target tissues in vivo
18F]fluoronor-hexestrol), a positron-emitting estrogen that shows highly-selective, receptor-mediated uptake by target tissues in vivo Life Sci 33 1983 1933 1938
Preparation of four fluorine-18-labeled estrogens and their selective uptakes in target tissues of immature rats
D.O. Kiesewetter, M.R. Kilbourn, S.W. Landvatter, D.F. Heiman, J.A. Katzenellenbogen, and M.J. Welch Preparation of four fluorine-18-labeled estrogens and their selective uptakes in target tissues of immature rats J Nucl Med 25 1984 1212 1221
Synthesis, radiolabeling and tissue distribution of 11β-fluoroalkyl- and 11β-fluoroalkoxy-substituted estrogens: Target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens
A.N. French, E. Napolitano, H.F. Vanbrocklin, R.N. Hanson, M.J. Welch, and J.A. Katzenellenbogen Synthesis, radiolabeling and tissue distribution of 11β-fluoroalkyl- and 11β-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens Nucl Med Biol 20 1993 31 47
18F]Fluoro)estrogens: Systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors
18F]Fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors J Med Chem 36 1993 1619 1629
A synthesis of 7α-substituted estradiols: Synthesis and biological evaluation of a 7α-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7α-pentylestradiol analog
A.N. French, S.R. Wilson, M.J. Welch, and J.A. Katzenellenbogen A synthesis of 7α-substituted estradiols: synthesis and biological evaluation of a 7α-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7α-pentylestradiol analog Steroids 58 1993 157 169
Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities
A.L. LaFrate, K.E. Carlson, and J.A. Katzenellenbogen Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities Bioorg Med Chem 17 2009 3528 3535
Oxohexestrol derivatives labeled with fluorine-18: Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents
K.E. Bergmann, S.W. Landvatter, P.G. Rocque, K.E. Carlson, M.J. Welch, and J.A. Katzenellenbogen Oxohexestrol derivatives labeled with fluorine-18: synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents Nucl Med Biol 21 1994 25 39
The synthesis of 7α-methyl-substituted estrogens labeled with fluorine-18: Potential breast tumor imaging agents
H.F. VanBrocklin, A. Liu, M.J. Welch, J.P. O'Neil, and J.A. Katzenellenbogen The synthesis of 7α-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents Steroids 59 1994 34 45
Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors
H.M. Bigott, E. Parent, L.G. Luyt, J.A. Katzenellenbogen, and M.J. Welch Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors Bioconjug Chem 16 2005 255 264
7α- and 17α-Substituted estrogens containing tridentate tricarbonyl rhenium/Technetium complexes: Synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m
L.G. Luyt, H.M. Bigott, M.J. Welch, and J.A. Katzenellenbogen 7α- and 17α-Substituted estrogens containing tridentate tricarbonyl rhenium/Technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m Bioorg Med Chem 11 2003 4977 4989
Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7α-substituted estradiol complexes
M.B. Skaddan, F.R. Wüst, S. Jonson, R. Syhre, M.J. Welch, and H. Spies Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7α-substituted estradiol complexes Nucl Med Biol 27 2000 269 278
Synthesis and binding affinities of novel Re-containing 7α-substituted estradiol complexes: Models for breast cancer imaging agents
M.B. Skaddan, F.R. Wüst, and J.A. Katzenellenbogen Synthesis and binding affinities of novel Re-containing 7α-substituted estradiol complexes: models for breast cancer imaging agents J Org Chem 64 1999 8108 8121
Synthesis and characterization of organometallic rhenium(I) and technetium(I) bile acid complexes
L.L. Huang, H. Zhu, X.P. Xu, C.C. Zhang, and Y.M. Shen Synthesis and characterization of organometallic rhenium(I) and technetium(I) bile acid complexes J Organomet Chem 694 2009 3247 3253
Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta
D. Caroline, L. Valérie, B. Geoffroy, P. Sophie, A. Éric, and B. Gervais Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta Steroids 73 2008 1077 1089
Synthesis of 17β-estradiol platinum(II) complexes: Biological evaluation on breast cancer cell lines
D. Caroline, P. Josée, M. Isabelle, P. Valérie, S.K. Mandal, and A. Éric Synthesis of 17β-estradiol platinum(II) complexes: biological evaluation on breast cancer cell lines Bioorg Med Chem Lett 13 2003 3927 3931
Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: Evidence that an open pocket conformation is required for ligand interaction
K.E. Carlson, I. Choi, A. Gee, B.S. Katzenellenbogen, and J.A. Katzenellenbogen Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction Biochemistry 36 1997 14897 14905
Evaluation of synthetic isoflavones on cell proliferation, estrogen receptor binding affinity, and apoptosis in human breast cancer cells
D.D. Davis, E.S. Díaz-Cruz, S. Landini, Y.W. Kim, and R.W. Brueggemeier Evaluation of synthetic isoflavones on cell proliferation, estrogen receptor binding affinity, and apoptosis in human breast cancer cells J Steroid Biochem Mol Biology 108 2008 23 31
Ambidentate coordination of the tripyridyl ligands 2,2′:6′, 2″-terpyridyl, tris(2-pyridyl)-amine, tris(2-pyridyl)methane and tris(2-pyridyl)-phosphine to carbonylrhenium centres: Structural and spectroscopic studies
P.A. Anderson, F.R. Keene, E. Horn, and E.R.T. Tiekink Ambidentate coordination of the tripyridyl ligands 2,2′:6′,2″-terpyridyl, tris(2-pyridyl)-amine, tris(2-pyridyl)methane and tris(2-pyridyl)-phosphine to carbonylrhenium centres: structural and spectroscopic studies Appl Organomet Chem 4 1990 523 533
