Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds

Shock

Volumn 26, Issue 2, 2006, Pages 201-209

  Ipaktchi, Kyros ^a   Mattar, Aladdein ^a   Niederbichler, Andreas D ^a   Hoesel, Laszlo M ^a   Hemmila, Mark R ^a   Su, Grace L ^a   Remick, Daniel G ^a   Wang, Stewart C ^a   Arbabi, Saman ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

BR; BR + SB; Burn and topical SB202190 application; Burn animals; EB; Evans blue; Hair follicle; Hair follicle apoptosis; HF; Inflammation; p38MAPK; Partial thickness burn; SB; SB202190; SH; Sham animals; Stress signaling

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; EVANS BLUE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; BURN; CELL DAMAGE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; EXTRAVASATION; HAIR FOLLICLE; INFLAMMATION; MALE; NEUTROPHIL; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN INFLAMMATION; STAINING; TISSUE INJURY;

ADMINISTRATION, TOPICAL; ANIMALS; APOPTOSIS; BURNS; CHEMOKINES, CXC; CYTOKINES; DERMATITIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; IMIDAZOLES; INTERLEUKIN-6; MALE; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 33746745351     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000225739.13796.f2     Document Type: Article

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