cPLA2 Is protective against COX inhibitor-induced intestinal damage

Toxicological Sciences

Volumn 117, Issue 1, 2010, Pages 122-132

  Montrose, David C ^a   Kadaveru, Krishna ^a   Ilsley, Jillian N M ^a   Root, Sierra H ^a   Rajan, Thiruchanduri V ^b   Ramesh, Manish ^b   Nichols, Frank C ^b   Liang, Bruce T ^c   Sonin, Dmitry ^c   Hand, Arthur R ^c   Zarini, Simona ^d   Murphy, Robert C ^d   Belinsky, Glenn S ^a   Nakanishi, Masako ^a   Rosenberg, Daniel W ^a  

^a Center for Molecular Medicine and Colon Cancer Prevention Program   (United States)

^b Department of Immunology ^*  (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

COX inhibitor; Cytosolic phospholipase A2; Intestine; Mitochondria

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE TRIPHOSPHATE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; CYTOSOLIC PHOSPHOLIPASE A2; PROSTAGLANDIN; ROFECOXIB; SULINDAC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTEREMIA; DIET; DISEASE PREDISPOSITION; DRUG EXPOSURE; ENTEROPATHY; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOTYPE; GEOGRAPHIC INFORMATION SYSTEM; INTESTINE INJURY; LETHALITY; MITOCHONDRION; MOUSE; NONHUMAN; PROSTAGLANDIN BLOOD LEVEL; SEPSIS; SMALL INTESTINE; UNIVERSITY; WILD TYPE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CYCLOOXYGENASE INHIBITORS; GENE EXPRESSION PROFILING; INTESTINES; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; PHOSPHOLIPASES A2, CYTOSOLIC; PROSTAGLANDINS; PYRAZOLES; SULFONAMIDES;

MUS;

EID: 77955886058     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq184     Document Type: Article

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