Embryo-fetal developmental toxicity of figitumumab, an anti-insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibody, in cynomolgus monkeys

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 89, Issue 4, 2010, Pages 326-338

  Bowman, Christopher J ^a   Chmielewski, Gary ^a   Oneda, Satoru ^b   Finco, Deborah ^a   Boucher, Mary A ^a   Todd, Marque ^a  

^a PFIZER INC   (United States)

^b SNBL USA Ltd   (United States)

Author keywords

Embryo fetal physiology; Maternal fetal interactions; Pharmaceuticals

Indexed keywords

ANTINEOPLASTIC AGENT; FIGITUMUMAB; MONOCLONAL ANTIBODY; SOMATOMEDIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; EMBRYOTOXICITY; FEMALE; FETAL WELL BEING; FETUS MALFORMATION; FETUS WASTAGE; FOOD INTAKE; GESTATIONAL AGE; GROWTH RETARDATION; IMMUNOGENICITY; INTRAUTERINE GROWTH RETARDATION; MONKEY; NONHUMAN; ORGANOGENESIS; PREGNANCY OUTCOME; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TOXICOKINETICS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTIBODIES, MONOCLONAL; ANTICARCINOGENIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; INSULIN-LIKE GROWTH FACTOR I; MACACA FASCICULARIS; MATERNAL-FETAL EXCHANGE; ORGANOGENESIS; PREGNANCY; RECEPTOR, IGF TYPE 1; TOXICITY TESTS;

MACACA FASCICULARIS;

EID: 77955867182     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.20248     Document Type: Article

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