A comparison of effects on reproduction and neonatal development in cynomolgus monkeys given human soluble IL-4R and mice given murine soluble IL-4R

Regulatory Toxicology and Pharmacology

Volumn 53, Issue 3, 2009, Pages 226-234

  Carlock, Linda L ^a,b   Cowan, Laine A ^a   Oneda, Satoru ^c   Hoberman, Alan ^d   Wang, Diane D ^a   Hanna, Roberta ^a   Bussiere, Jeanine L ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

^c SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

^d CHARLES RIVER LABORATORIES   (United States)

Author keywords

Cynomolgus monkeys; Fetal development; Mice; Natural delivery; Neonatal development; Reproduction; Soluble IL 4 receptor

Indexed keywords

INTERLEUKIN RECEPTOR; SOLUBLE INTERLEUKIN 4 RECEPTOR; UNCLASSIFIED DRUG; INTERLEUKIN 4 RECEPTOR; RECOMBINANT PROTEIN;

ABORTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO DEATH; EMBRYOTOXICITY; FETUS DEATH; MONKEY; MOUSE; NONHUMAN; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; REPRODUCTION; STILLBIRTH; ABNORMALITIES, DRUG-INDUCED; ANIMAL; BODY WEIGHT; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EMBRYO DEVELOPMENT; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS DEVELOPMENT; HUMAN; MALE; NEWBORN; ORGAN SIZE; ORGANOGENESIS; PATHOLOGY; PREGNANCY; SOLUBILITY; SPECIES DIFFERENCE; TOXICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANIMALS, NEWBORN; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; FEMALE; FETAL DEVELOPMENT; HUMANS; MALE; MATERNAL EXPOSURE; MICE; ORGAN SIZE; ORGANOGENESIS; PREGNANCY; RECEPTORS, INTERLEUKIN-4; RECOMBINANT PROTEINS; REPRODUCTION; SOLUBILITY; SPECIES SPECIFICITY;

MACACA FASCICULARIS; MURINAE; MUS;

EID: 62549098687     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.02.001     Document Type: Article

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