Novel N -methylated 8-oxoisoguanines from pacific sponges with diverse neuroactivities

Journal of Medicinal Chemistry

Volumn 53, Issue 16, 2010, Pages 6089-6099

  Sakurada, Tsuyoshi ^a   Gill, Martin B ^b   Frausto, Shanti ^b   Copits, Bryan ^b   Noguchi, Keiichi ^c   Shimamoto, Keiko ^d   Swanson, Geoffrey T ^b   Sakai, Ryuichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b NORTHWESTERN UNIVERSITY   (United States)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^d SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,9 DIMETHYL 8 OXOISOGUANINE; N METHYLATED 8 OXOISOGUANINE DERIVATIVE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG ISOLATION; DRUG STRUCTURE; ELECTROPHYSIOLOGY; GABAERGIC TRANSMISSION; HAPLOSCLERIDA; HIPPOCAMPUS; MALE; MARINE SPECIES; MOUSE; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PALAU; SEIZURE; SPONGE (PORIFERA); X RAY SPECTROMETRY;

ACTION POTENTIALS; ANIMALS; BEHAVIOR, ANIMAL; CELLS, CULTURED; CONVULSANTS; CRYSTALLOGRAPHY, X-RAY; EXCITATORY POSTSYNAPTIC POTENTIALS; GUANINE; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIALS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; NEURONS; PALAU; PATCH-CLAMP TECHNIQUES; PORIFERA; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; SYNAPTIC TRANSMISSION;

EID: 77955862755     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100490m     Document Type: Article

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