Multiplexed antibody detection with an array of silicon-on-insulator microring resonators

IEEE Photonics Journal

Volumn 1, Issue 4, 2009, Pages 225-235

  De Vos, Katrien ^a   Girones, Jordi ^a   Claes, Tom ^a   De Koninck, Yannick ^a   Popelka, Stepan ^a   Schacht, Etienne ^a   Baets, Roel ^a   Bienstman, Peter ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Biosensors; Label free; Microfluidics; Resonators; Silicon nanophotonics; Waveguides

Indexed keywords

AFFINITY INTERACTIONS; ANTIBODY DETECTION; BIOMOLECULAR INTERACTIONS; BIOSENSING; HIGH DEMAND; HIGH SENSITIVITY; INFRA-RED CAMERAS; LAB ON A CHIP; LABEL FREE; LABEL-FREE MONITORING; LOW TEMPERATURES; MASS FABRICATION; METAL-OXIDE; MICRORING RESONATOR; OPTICAL CAVITIES; OPTICAL CHIPS; POLYDIMETHYLSILOXANE PDMS; PROTEOMICS; PROTOTYPE SENSOR; SILICON ON INSULATOR; SIMULTANEOUS DETECTION; STANDARD CMOS TECHNOLOGY; TOTAL MASS;

ANTIBODIES; BIOSENSORS; CHIP SCALE PACKAGES; CMOS INTEGRATED CIRCUITS; ETHYLENE; ETHYLENE GLYCOL; FABRICATION; LABELS; MICROFLUIDICS; MICROSENSORS; MOLECULAR BIOLOGY; MULTIPLEXING; NANOPHOTONICS; OPTICAL RESONATORS; PHOTONICS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SILICONES; WAVEGUIDES;

SILICON ON INSULATOR TECHNOLOGY;

EID: 77955861886     PISSN: 19430655     EISSN: None     Source Type: Journal    
DOI: 10.1109/JPHOT.2009.2035433     Document Type: Article

References (25)

1. W. E. Moerner, "New directions in single-molecule imaging and analysis" Proc. Nat. Acad. Sci., vol. 104, no. 31, pp. 12 596-12 602, Sep. 2007.
2. X. Yu, D. Xu, and Q. Cheng, "Label-free detection methods for protein microarrays" Proteomics, vol. 6, no. 20, pp. 5493-5503, Oct. 2006.
3. A. J. Qavi, A. L. Washburn, J. Y. Byeon, and R. C. Bailey, "Label-free technologies for quantitative multiparameter biological analysis" Anal. Bioanal. Chem., vol. 394, no. 1, pp. 121-135, May 2009.
4. A. Ymeti, J. Greve, P. V. Lambeck, T. Wink, S. W. F. M. Van Hövell, T. A. M. Beumer, R. Wijn, R. G. Heideman, V. Subramaniam, and J. S. Kanger, "Fast, ultrasensitive virus detection using a young interferometer sensor" Nano Lett., vol. 7, no. 2, pp. 394-397, Feb. 2007. (Pubitemid 46383604)
5. L. M. Lechuga, K. Zinoviev, L. Fernandez, J. Elizalde, O. E. Hidalgo, and C. Dominguez, "Biosensing microsystem platforms based on the integration of Si Mach-Zehnder interferometer, microfluidics and grating couplers" Proc. SPIE, vol. 7220, p. 722 00L, 2009.
6. X. Wei, C. Kang, G. Rong, S. T. Retterer, and S. M. Weiss, "Porous silicon waveguide with integrated grating coupler for DNA sensing" Proc. SPIE, vol. 7167, p. 716 70C, 2009.
7. S. Grego and B. R. Stoner, "Wavelength interrogation of optical waveguide biosensors in the input grating coupler configuration" Proc. SPIE, vol. 7218, p. 721 f81A, 2009.
8. P. P. P. Debackere, S. Scheerlinck, P. Bienstman, and R. Baets, "Surface plasmon interferometer in silicon-oninsulator: Novel concept for an integrated biosensor" Opt. Express, vol. 14, no. 16, pp. 7063-7072, Aug. 2006.
9. F. Vollmer and S. Arnold, "Whispering-gallery-mode biosensing: Label-free detection down to single molecules" Nat. Methods, vol. 5, no. 7, pp. 591-596, Jul. 2008.
10. A. M. Armani, R. K. Kulkarni, S. E. Fraser, R. C. Flagan, and K. J. Vahala, "Label-free, single-molecule detection with optical microcavities" Science, vol. 317, no. 5839, pp. 783-787, Aug. 2007.
11. C. Y. Chao and L. J. Guo, "Polymer microring resonators for biochemical sensing applications" IEEE J. Sel. Topics Quantum Electron., vol. 12, no. 1, pp. 134-142, Jan./Feb. 2006.
12. D. X. Xu, A. Densmore, A. Delage, P. Waldron, R. McKinnon, S. Janz, J. Lapointe, G. Lopinski, T. Mischki, E. Post, P. Cheben, and J. H. Schmid, "Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding" Opt. Express, vol. 16, no. 19, pp. 15 137-15 148, Sep. 2008.
13. A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, "A universal biosensing platform based on optical micro-ring resonators" Biosens. Bioelectron., vol. 23, no. 7, pp. 939-944, Feb. 2008.
14. W. Bogaerts, R. Baets, P. Dumon, V. Wiaux, S. Beckx, D. Taillaert, B. Luyssaert, J. Van Campenhout, P. Bienstman, and D. Van Thourhout, "Nanophotonic waveguides in silicon-on-insulator fabricated with CMOS technology" J. Lightw. Technol., vol. 23, no. 1, pp. 401-412, Jan. 2005. (Pubitemid 40181733)
15. S. K. Selvaraja, P. Jaenen, W. Bogaerts, D. Van Thourhout, P. Dumon, and R. G. Baets, "Fabrication of photonic wire and crystal circuits in silicon-on-insulator using 193-nm optical lithography" J. Lightw. Technol., vol. 27, no. 8, pp. 4076-4083, Sep. 2009.
16. I. M. White and X. Fan, "On the performance quantification of resonant refractive index sensors " Opt. Express, vol. 16, no. 2, pp. 1020-1028, Jan. 2008.
17. J. Vörös, "The density and refractive index of adsorbing protein layers" Biophys. J., vol. 87, no. 1, pp. 553-561, Jul. 2004.
18. J. Hu, X. Sun, A. Agarwal, and L. C. Kimerling, "Design guidelines for optical resonator biochemical sensors" J. Opt. Soc. Amer. B, Opt. Phys., vol. 26, no. 5, pp. 1032-1041, May 2009.
19. T. Claes, J. Girones Molera, K. De Vos, E. Schacht, R. Baets, and P. Bienstman, "Label-free biosensing with a slot waveguide based ring resonator in silicon-on-insulator" IEEE Photon. J., vol. 1, no. 3, pp. 197-204, Sep. 2009.
20. K. De Vos, I. Bartolozzi, E. Schacht, P. Bienstman, and R. Baets, "Silicon-on-insulator microring resonator for sensitive and label-free biosensing" Opt. Express, vol. 15, no. 12, pp. 7610-7615, Jun. 2007.
21. S. Bhattacharya, A. Datta, J. M. Berg, and S. Gangopadhyay, "Studies on surface wettability of poly(dimethyl) siloxane (PDMS) and glass under oxygen-plasma treatment and correlation with bond strength" J. Microelectromech. Syst., vol. 14, no. 3, pp. 590-597, Jun. 2005.
22. S. Satyanarayana, R. N. Karnik, and A. Majumdar, "Stamp-and-stick room-temperature bonding technique for microdevices" J. Microelectromech. Syst., vol. 14, no. 2, pp. 392-399, Apr. 2005.
23. K. De Vos, J. Girones, S. Popelka, E. Schacht, R. Baets, and P. Bienstman, "ical microring resonator with poly(ethylene glycol) polymer brush for label-free biosensor applications"s. Bioelectron., vol. 24, no. 8, pp. 2528-2533, Apr. 2009.
24. A. Wolter, R. Niessner, and M. Seidel, "tion and characterization of functional poly(ethylene glycol) surfaces for the use of antibody microarrays"Chem., vol. 79, no. 12, pp. 4529-4537, Jun. 2007.
25. E. W. Olle, J. Messamore, M. P. Deogracias, S. D. McClintock, T. D. Anderson, and K. J. Johnson, "son of antibody array substrates and the use of glycerol to normalize spot morphology"ol. Pathol., vol. 79, no. 3, pp. 206-209, Dec. 2005.