Reverse engineering truncations of an antimicrobial peptide dimer to identify the origins of potency and broad spectrum of action

Journal of Medicinal Chemistry

Volumn 53, Issue 16, 2010, Pages 6079-6088

  Anantharaman, Aparna ^a   Sahal, Dinkar ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; POLYPEPTIDE ANTIBIOTIC AGENT; SYNTHETIC PEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; BACTERIAL OUTER MEMBRANE; BACTERICIDAL ACTIVITY; CELL PERMEABILIZATION; CIRCULAR DICHROISM; DRUG DESIGN; DRUG POTENCY; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; PHYSICAL CHEMISTRY; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; DIMERIZATION; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; PROTEIN STRUCTURE, SECONDARY; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955859937     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100483y     Document Type: Article

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