4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells

Molecular and Cellular Biochemistry

Volumn 342, Issue 1-2, 2010, Pages 133-142

  Bijangi Vishehsaraei, Khadijeh ^a,b   Saadatzadeh, Mohammad Reza ^a   Huang, Su ^a,b   Murphy, Michael P ^a   Safa, Ahmad R ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 (4 Chloro 2 methylphenoxy) N hydroxybutanamide (CMH); Apoptosis; Breast cancer; c FLIP; Caspases; Death receptors

Indexed keywords

4 (4 CHLORO 2 METHYLPHENOXY) N HYDROXYBUTANAMIDE; ANTINEOPLASTIC AGENT; CASPASE 10; CASPASE 8; FLICE INHIBITORY PROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL PROLIFERATION; FEMALE; HUMANS; HYDROXAMIC ACIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 77955850542     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0477-7     Document Type: Article

References (45)

1. GM Cereghetti L Scorrano 2006 The many shapes of mitochondrial death Oncogene 25 4717 4724 10.1038/sj.onc.1209605 1:CAS:528:DC%2BD28Xnsl2hsLg%3D 16892085 (Pubitemid 44187621)
2. KM Debatin PH Krammer 2004 Death receptors in chemotherapy and cancer Oncogene 23 2950 2966 10.1038/sj.onc.1207558 1:CAS:528:DC%2BD2cXivFKmsbw%3D 15077156 (Pubitemid 38638855)
3. AR Safa TW Day CH Wu 2008 Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy Curr Cancer Drug Targets 8 37 46 10.2174/156800908783497087 1:CAS:528:DC%2BD1cXitF2ku7Y%3D 18288942 (Pubitemid 351237908)
4. MB Valnet-Rabier B Challier S Thiebault R Angonin G Margueritte C Mougin B Kantelip E Deconinck JY Cahn T Fest 2005 c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome Br J Haematol 128 767 773 10.1111/j.1365-2141.2005.05378.x 1:CAS:528:DC%2BD2MXjt1CltL0%3D 15755279 (Pubitemid 40444868)
5. S Gao H Wang P Lee J Melamed CX Li F Zhang H Wu L Zhou Z Wang 2006 Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland J Mol Endocrinol 36 463 483 10.1677/jme.1.01991 1:CAS:528:DC%2BD28XmtFSrtLs%3D 16720717 (Pubitemid 43904941)
6. JC Morales MJ Ruiz-Magana C Ruiz-Ruiz 2007 Regulation of the resistance to TRAIL-induced apoptosis in human primary T lymphocytes: role of NF-kappaB inhibition Mol Immunol 44 2587 2597 10.1016/j.molimm.2006.12.015 1:CAS:528:DC%2BD2sXhvVSlsr4%3D 17257681 (Pubitemid 46240328)
7. SJ Park MJ Kim HB Kim CD Kang SH Kim 2009 Sensitization of imatinib-resistant CML cells to TRAIL-induced apoptosis is mediated through down-regulation of Bcr-Abl as well as c-FLIP Biochem J 420 73 81 10.1042/BJ20082131 1:CAS:528:DC%2BD1MXltFCjtr8%3D 19203346
8. PA Christian JA Thorpe SR Schwarze 2009 Velcade sensitizes prostate cancer cells to TRAIL induced apoptosis and suppresses tumor growth in vivo Cancer Biol Ther 8 73 80 1:CAS:528:DC%2BD1MXptVenurk%3D 19029816
9. JY Kim EH Kim SS Park JH Lim TK Kwon KS Choi 2008 Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation J Cell Biochem 105 1386 1398 10.1002/jcb.21958 1:CAS:528:DC%2BD1cXhsFaks7fK 18980244
10. Bagnoli M, Canevari S, Mezzanzanica D (2009) Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer. Int J Biochem Cell Biol [Epub ahead of print]
11. TW Day AR Safa 2009 RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery Mini Rev Med Chem 9 741 748 10.2174/138955709788452748 1:CAS:528:DC%2BD1MXnslejsrw%3D 19519499
12. L Galligan DB Longley M McEwan TR Wilson K McLaughlin PG Johnston 2005 Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP Mol Cancer Ther 4 2026 2036 10.1158/1535-7163.MCT-05-0262 1:CAS:528:DC%2BD2MXhtlCnsrjL 16373718 (Pubitemid 43056986)
13. DB Longley TR Wilson M McEwan WL Allen U McDermott L Galligan PG Johnston 2006 c-FLIP inhibits chemotherapy-induced colorectal cancer cell death Oncogene 25 488 838 10.1038/sj.onc.1209122 (Pubitemid 43237702)
14. GM Cohen 2007 Caspases: the executioners of apoptosis Biochem J 326 1 16
15. A Krueger S Baumann PH Krammer S Kirchhoff 2001 FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis Mol Cell Biol 21 8247 8254 10.1128/MCB.21.24.8247-8254.2001 1:CAS:528:DC%2BD3MXovVegs7o%3D 11713262 (Pubitemid 33108586)
16. TW Day F Najafi CH Wu 2006 Cellular FLICE-like inhibitory protein (c-FLIP): a novel target for Taxol-induced apoptosis Biochem Pharmacol 71 1551 1561 10.1016/j.bcp.2006.02.015 1:CAS:528:DC%2BD28XktVOqtLg%3D 16579975
17. X Du G Bao X He H Zhao F Yu Q Qiao J Lu Q Ma 2009 Expression and biological significance of c-FLIP in human hepatocellular carcinomas J Exp Clin Cancer Res 28 24 10.1186/1756-9966-28-24 19232089
18. O Micheau M Thome P Schneider N Holler J Tschopp DW Nicholson C Briand MG Grütter 2002 The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex J Biol Chem 277 45162 45171 10.1074/jbc.M206882200 1:CAS:528:DC%2BD38Xosl2ls7s%3D 12215447 (Pubitemid 36159119)
19. DA Sharp DA Lawrence A Ashkenazi 2005 Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis J Biol Chem 280 10409 19401 10.1074/jbc.M413962200 (Pubitemid 41379648)
20. DW Chang Z Xing Y Pan A Algeciras-Schimnich BC Barnhart S Yaish-Ohad ME Peter X Yang 2002 c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis EMBO J 21 3704 3714 10.1093/emboj/cdf356 1:CAS:528:DC%2BD38XlslOktb4%3D 12110583 (Pubitemid 34787044)
21. MG Valmiki JW Ramos 2009 Death effector domain-containing proteins Cell Mol Life Sci 66 814 830 10.1007/s00018-008-8489-0 1:CAS:528:DC%2BD1MXisVOrsrg%3D 18989622
22. EE Varfolomeev M Schuchmann V Luria N Chiannilkulchai JS Beckmann IL Mett D Rebrikov VM Brodianski OC Kemper O Kollet T Lapidot D Soffer T Sobe KB Avraham T Goncharov H Holtmann P Lonai D Wallach 1998 Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally Immunity 9 267 276 10.1016/S1074-7613(00)80609-3 1:CAS:528:DyaK1cXlvVemtLs%3D 9729047
23. WC Yeh JL Pompa ME McCurrach HB Shu AJ Elia A Shahinian M Ng A Wakeham W Khoo K Mitchell WS El-Deiry SW Lowe DV Goeddel TW Mak 1998 FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis Science 279 1954 1958 10.1126/science.279.5358.1954 1:STN:280: DyaK1c7ns1Sitw%3D%3D 9506948 (Pubitemid 28168653)
24. TW Day S Huang AR Safa 2008 c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells Biochem Pharmacol 76 1694 1704 10.1016/j.bcp.2008.09.007 1:CAS:528:DC%2BD1cXhsVGgtrzN 18840411
25. KM Rogers M Thomas L Galligan TR Wilson WL Allen H Sakai PG Johnston DB Longley 2007 Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells Mol Cancer Ther 6 1544 1551 10.1158/1535-7163.MCT-06-0673 1:CAS:528:DC%2BD2sXotFaltLo%3D 17513603 (Pubitemid 46954021)
26. TR Wilson KM McLaughlin M McEwan H Sakai KM Rogers KM Redmond PG Johnston DB Longley 2007 c-FLIP: a key regulator of colorectal cancer cell death Cancer Res 67 5754 5762 10.1158/0008-5472.CAN-06-3585 1:CAS:528:DC%2BD2sXmsFCqsb0%3D 17575142 (Pubitemid 46985008)
27. HH Cheung DJ Mahoney EC Lacasse RG Korneluk 2009 Down-regulation of c- FLIP Enhances death of cancer cells by smac mimetic compound Cancer Res 69 7729 7738 10.1158/0008-5472.CAN-09-1794 1:CAS:528:DC%2BD1MXht1Skt7jE 19773432
28. TW Day AL Sinn S Huang KE Pollok GE Sandusky AR Safa 2009 c-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells Anticancer Res 29 3883 3886 19846923
29. Chen F, Guo J, Zhang Y, Zhao Y, Zhou N, Liu S, Liu Y, Zheng D (2009) Knockdown of c-FLIP(L) enhanced AD5-10 anti-death receptor 5 monoclonal antibody-induced apoptosis in human lung cancer cells. Cancer Sci 100(5):940-947 [Epub 2009 Feb 19; Erratum in: Cancer Sci. 2009 Dec;100(12):2469]
30. JS Lee Q Li JY Lee SH Lee JH Jeong HR Lee H Chang FC Zhou SJ Gao C Liang JU Jung 2009 FLIP-mediated autophagy regulation in cell death control Nat Cell Biol 11 1355 1362 10.1038/ncb1980 1:CAS:528:DC%2BD1MXhtlCnu73J 19838173
31. M Naito R Katayama T Ishioka A Suga K Takubo M Nanjo C Hashimoto M Taira S Takada R Takada M Kitagawa S Matsuzawa JC Reed T Tsuruo 2004 Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling Mol Cell Biol 24 2847 8418 10.1128/MCB.24.19.8418-8427.2004 (Pubitemid 39245064)
32. K Shimada M Nakamura S Matsuyoshi E Ishida N Konishi 2006 Specific positive and negative effects of FLIP on cell survival in human prostate cancer Carcinogenesis 27 1349 1357 10.1093/carcin/bgi380 1:CAS:528:DC%2BD28XmsVegu7w%3D 16537561 (Pubitemid 43985410)
33. R Katayama T Ishioka S Takada R Takada N Fujita T Tsuruo M Naito 2010 Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L J Cell Sci 123 23 28 10.1242/jcs.058602 1:CAS:528:DC%2BC3cXhsFejtb0%3D 20016063
34. N Rathore H Matta PM Chaudhary 2004 An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha J Biol Chem 279 39358 39365 10.1074/jbc.M406712200 1:CAS:528:DC%2BD2cXnsVKksLc%3D 15252032 (Pubitemid 39258198)
35. W Wang S Wang X Song N Sima X Xu A Luo G Chen D Deng Q Xu L Meng Y Lu D Ma 2007 The relationship between c-FLIP expression and human papillomavirus E2 gene disruption in cervical carcinogenesis Gynecol Oncol 105 571 577 10.1016/j.ygyno.2007.01.051 1:CAS:528:DC%2BD2sXlsFKisb0%3D 17433827 (Pubitemid 46734183)
36. D Gilot AL Serandour GP Ilyin D Lagadic-Gossmann P Loyer A Corlu A Coutant G Baffet ME Peter O Fardel C Guguen-Guillouzo 2005 A role for caspase-8 and c- FLIPL in proliferation and cell-cycle progression of primary hepatocytes Carcinogenesis 26 2086 2094 10.1093/carcin/bgi187 1:CAS:528:DC%2BD2MXht1entL7K 16033771 (Pubitemid 41672196)
37. HX Chen YJ Liu XD Zhou RY Luo 2005 Expression of cellular FLICE/caspase-8 inhibitory protein is associated with malignant potential in endometrial carcinoma Int J Gynecol Cancer 15 663 670 10.1111/j.1525-1438.2005.00122.x 16014121 (Pubitemid 41022905)
38. XD Zhou JP Yu HX Chen HG Yu HS Luo 2005 Expression of cellular FLICE- inhibitory protein and its association with p53 mutation in colon cancer World J Gastroenterol 11 2482 2485 1:CAS:528:DC%2BD2MXltVWitrk%3D 15832422
39. D Carlisi M Lauricella A D'Anneo S Emanuele L Angileri P Di Fazio A Santulli R Vento G Tesoriere 2009 The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation Eur J Cancer 45 2425 2438 10.1016/j.ejca.2009.06.024 1:CAS:528:DC%2BD1MXhtVegs7%2FM 19643600
40. Schimmer AD, Thomas MP, Hurren R, Gronda M, Pellecchia M, Pond GR, Konopleva M, Gurfinkel D, Mawji IA, Brown E, Reed JC (2006) Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer Res 66(4):2367-2375
41. IA Mawji CD Simpson R Hurren M Gronda MA Williams J Filmus J Jonkman RS Da Costa BC Wilson MP Thomas JC Reed GV Glinsky AD Schimmer 2007 Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation J Natl Cancer Inst 99 811 822 10.1093/jnci/djk182 1:CAS:528:DC%2BD2sXnt1ags7g%3D 17505076 (Pubitemid 47073526)
42. J Gordon CH Wu M Rastegar AR Safa 2003 Beta2-microglobulin induces caspase- dependent apoptosis in the CCRF-HSB-2 human leukemia cell line independently of the caspase-3, -8 and -9 pathways but through increased reactive oxygen species Int J Cancer 103 316 327 10.1002/ijc.10828 1:CAS:528:DC%2BD3sXht1yjtw%3D%3D 12471614 (Pubitemid 36076424)
43. A Dutton JD O'Neil AE Milner GM Reynolds J Starczynski J Crocker LS Young PG Murrat 2004 Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death Proc Natl Acad Sci USA 101 6611 6616 10.1073/pnas.0400765101 1:CAS:528: DC%2BD2cXjvVyiu78%3D 15096587 (Pubitemid 38586022)
44. T Kataoka 2005 The caspase-8 modulator c-FLIP Crit Rev Immunol 25 31 58 10.1615/CritRevImmunol.v25.i1.30 1:CAS:528:DC%2BD2MXktlajs7c%3D 15833082 (Pubitemid 40733355)
45. TF Burns WS El-Deiry 2001 Identification of inhibitors of TRAIL-induced death (ITIDs) in the TRAIL sensitive colon carcinoma cell line SW480 using a genetic approach J Biol Chem 276 37879 37886 1:CAS:528:DC%2BD3MXotFOrt7g%3D 11486001