Linking long-term toxicity of xeno-chemicals with short-term biological adaptation

Biochimie

Volumn 92, Issue 9, 2010, Pages 1222-1226

  Barouki, Robert ^a,b  

^a INSERM   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Aryl hydrocarbon receptor; Cytochromes P450; Toxicity; Xenobiotic metabolizing enzymes; Xenobiotic receptors

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; DIOXIN; ELECTROPHILE; ESTROGEN RECEPTOR; POLYCYCLIC AROMATIC HYDROCARBON; REACTIVE OXYGEN METABOLITE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR NRF2;

ADAPTATION; ADIPOSE TISSUE; CYTOTOXICITY; HYDROPHOBICITY; MOLECULAR INTERACTION; OXIDATIVE STRESS; PROTEIN INTERACTION; REVIEW; XENOBIOTIC METABOLISM; XENOBIOTIC STRESS;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; XENOBIOTICS;

EID: 77955846420     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.02.026     Document Type: Review

References (32)

1. Holsapple M.P., Wallace K.B. Dose response considerations in risk assessment-an overview of recent ILSI activities. Toxicol. Lett. 2008, 180:85-92.
2. Julien E., Boobis A.R., Olin S.S. The key events dose-response framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds,. Crit. Rev. Food Sci. Nutr. 2009, 49:682-689. Ilsi Research Foundation Threshold Working Group.
3. Neumann H.G. Risk assessment of chemical carcinogens and thresholds. Crit. Rev. Toxicol. 2009, 39:449-461.
4. Bolt H.M. Genotoxicity-threshold or not? Introduction of cases of industrial chemicals. Toxicol. Lett. 2003, 140-141:43-51.
5. Fukushima S., Kinoshita A., Puatanachokchai R., Kushida M., Wanibuchi H., Morimura K. Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens. Carcinogenesis 2005, 26(:1835-1845.
6. Hue O., Marcotte J., Berrigan F., Simoneau M., Doré J., Marceau P., Marceau S., Tremblay A., Teasdale N. Increased plasma levels of toxic pollutants accompanying weight loss induced by hypocaloric diet or by bariatric surgery. Obes. Surg. 2006, 16:1145-1154.
7. Nebert D.W., Dalton T.P. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat. Rev. Cancer 2006, 6:947-960.
8. Barouki R., Morel Y. Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications. Biochem. Pharmacol. 2001, 61:511-516.
9. Geyer H.J., Scheunert I., Rapp K., Gebefügi I., Steinberg C., Kettrup A. The relevance of fat content in toxicity of lipophilic chemicals to terrestrial animals with special reference to dieldrin and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD),. Ecotoxicol. Environ. Saf. 1993, 26:45-60.
10. Barouki R., Coumoul X., Fernandez-Salguero P.M. The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein. FEBS Lett. 2007, 581:3608-3615.
11. Osburn W.O., Kensler T.W. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat. Res. 2008, 659:31-39.
12. Morel Y., Mermod N., Barouki R. An autoregulatory loop controlling CYP1A1 gene expression: role of H(2)O(2) and NFI. Mol. Cell Biol. 1999, 19:6825-6832.
13. Marchand A., Barouki R., Garlatti M. Regulation of NAD(P)H:quinone oxidoreductase 1 gene expression by CYP1A1 activity. Mol. Pharmacol. 2004, 65:1029-1037.
14. öhle C.K., Bock K.W. Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem. Pharmacol. 2007, 73(:1853-1862.
15. Denissenko M.F., Pao A., Tang M., Pfeifer G.P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 1996, 274:430-432.
16. Nebert D.W., Dalton T.P., Okey A.B., Gonzalez F.J. Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J. Biol. Chem. 2004, 279:23847-23850.
17. Uno S., Dalto T.P., Dragin N., Curran C.P., Derkenne S., Miller M.L., Shertzer H.G., Gonzalez F.J., Nebert D.W. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol. Pharmacol. 2006, 69:1103-1114.
18. Johnson E.F., Stout C.D. Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases. Biochem. Biophys. Res. Commun. 2005, 338:331-336.
19. Coumoul X., Diry M., Robillot C., Barouki R. Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Cancer Res. 2001, 61:3942-3948.
20. Gonzalez F.J., Fernandez-Salguero P. The aryl hydrocarbon receptor: studies using the AHR-null mice. Drug Metab. Dispos. 1998, 26:1194-1198.
21. Lahvis G.P., Bradfield C.A. Ahr null alleles: distinctive or different?. Biochem. Pharmacol. 1998, 56:781-787.
22. Nguyen L.P., Bradfield C.A. The search for endogenous activators of the aryl hydrocarbon receptor. Chem. Res. Toxicol. 2008, 21:102-116.
23. Puga A., Tomlinson C.R., Xia Y. Ah receptor signals cross-talk with multiple developmental pathways. Biochem. Pharmacol. 2005, 69:199-207.
24. Bui L.C., Tomkiewicz C., Chevallier A., Pierre S., Bats A.S., Mota S., Raingeaud J., Pierre J., Diry M., Transy C., Garlatti M., Barouki R., Coumoul X. Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity. Oncogene 2009, 28:3642-3651.
25. Carvajal-Gonzalez J.M., Mulero-Navarro S., Roman A.C., Sauzeau V., Merino J.M., Bustelo X.R., Fernandez-Salguero P.M. The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion. Mol. Biol. Cell 2009, 20:1715-1727.
26. Sartor M.A., Schnekenburger M., Marlowe J.L., Reichard J.F., Wang Y., Fan Y., Ma C., Karyala S., Halbleib D., Liu X., Medvedovic M., Puga A. Genomewide analysis of aryl hydrocarbon receptor binding targets reveals an extensive array of gene clusters that control morphogenetic and developmental programs. Environ. Health Perspect. 2009, 117:1139-1146.
27. Gouédard C., Barouki R., Morel Y. Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol. Cell Biol. 2004, 24:5209-5222.
28. Bock K.W., Köhle C. Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem. Pharmacol. 2006, 72:393-404.
29. Ohtake F., Baba A., Takada I., Okada M., Iwasaki K., Miki H., Takahashi S., Kouzmenko A., Nohara K., Chiba T., Fujii-Kuriyama Y., Kato S. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 2007, 446:562-566.
30. Martin G.M. Modalities of gene action predicted by the classical evolutionary biological theory of aging. Ann. N. Y. Acad. Sci. 2007, 1100:14-20.
31. Kirkwood T.B. Understanding the odd science of aging. Cell 2005, 120:437-447.
32. Lambeth J.D. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic. Biol. Med. 2007, 43:332-347.