Bone quality: Understanding what matters

Journal of Musculoskeletal Neuronal Interactions

Volumn 4, Issue 2, 2004, Pages 184-186

  Burr, David B ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Architecture; Bone quality; Microdamage; Mineralization; Osteoporosis

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1;

ADULT; AGED; AGING; ARTICLE; BONE DENSITY; BONE FRAGILITY; BONE INJURY; BONE MASS; BONE MATRIX; BONE MINERAL; BONE MINERALIZATION; BONE STRENGTH; BONE STRUCTURE; BONE TURNOVER; CANCELLOUS BONE; FEMALE; GEOMETRY; HUMAN; OSTEOLYSIS; RISK ASSESSMENT; VERTEBRA FRACTURE;

BONE AND BONES; BONE DENSITY; FRACTURES, BONE; HUMANS;

EID: 3042818397     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Hui S, Slemenda CW, Johnston CC. Age and bone mass as predictors of fracture in a prospective study. J Clin Invest 1988; 81:1804-1809.
2. Riggs BL, Melton LJ III. Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density. J Bone Miner Res 2002; 17:11-14.
3. Parfitt AM. High bone turnover is intrinsically harmful: two paths to a similar conclusion. J Bone Miner Res 2002; 17:1558-1559.
4. Van der Linden JC, Verhaar JAN, Weinans H. A 3-D simulation of age-related remodeling in cancellous bone. J Bone Miner Res 2001; 16:688-696.
5. Weinans H. Architectural changes independent of bone mineral in osteoporosis. Presented at the 32nd International Sun Valley Hard Tissue Workshop; 2002.
6. Currey JD. The effect of strain rate, reconstruction and mineral content on some mechanical properties of bovine bone. J Biomech 1975; 8:81-86.
7. Currey JD, Brear K, Zioupos P. The effects of aging and changes in mineral content in degrading the toughness of human femora. J Biomech 1996; 29:257-260.
8. Meunier PJ, Boivin G. Bone mineral density reflects bone mass but also the degree of mineralization of bone: therapeutic implications. Bone 1997; 21:373-377.
9. Boivin G, Chavassieux PM, Santora AC, Yates, J, Meunier PJ. Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women. Bone 2000; 27:687-694.
10. Roschger P, Rinnerhtaler S, Yates J, Rodan GA, Fratzl P, Klaushofer K. Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 2001; 29:185-191.
11. Nuzzo S, Lafage-Proust MH, Martin-Badosa E, Boivin G, Thomas T, Alexandre C, Peyrin F. Synchrotron radiation microtomography allows the analysis of three-dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effects of etidronate treatment. J Bone Miner Res 2002, 17:1372-1382.
12. 3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women. J Clin Endocrinol Metab 2003; 88:4199-4205.
13. Burr DB. The contribution of the organic matrix to bone's mechanical properties. Bone 2002; 31:8-11.
14. Mann V, Ralston SH. Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture. Bone 2003; 32:711-717.
15. Burr DB, Turner CH. Biomechanical measurements in age-related bone loss. In: Rosen CJ, Glowacki J, Bilezikian JP (eds) The Aging Skeleton. Academic Press, San Diego; 1999:301-311.
16. Burr DB, Forwood MR, Fyhrie DP, Martin RB, Schaffler MB, Turner CH. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J Bone Miner Res 1997; 12:6-15.
17. Courtney AC, Hayes WC, Gibson LJ. Age-related differences in post-yield damage in human cortical bone. Experiment and model. J Biomech. 1996; 29:1463-1471.
18. Schaffler MB, Choi K, Milgrom C. Aging and matrix microdamage accumulation in human compact bone. Bone 1995; 17:521-525.
19. Mori S, Harruff R, Ambrosius W, Burr DB. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone 1997; 21:521-526.
20. Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P. Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 1998; 22:381-388.
21. Zioupos P. Accumulation of in vivo fatigue microdamage and its relation to biomechanical properties in ageing human cortical bone. J Microsc 2001; 201:270-278.
22. Mashiba T, Turner CH, Hirano T, Forwood MR, Johnston CC, Burr DB. The effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites of beagles. Bone 2001; 28:524-531.
23. Komatsubara S, Mori S, Mashiba T, Ito M, Li J, Kaji Y, Akiyama T, Miyamoto, K, Cao Y, Kawanishi J, Norimatsu H. Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra. J Bone Miner Res 2003; 18:512-520.
24. Mashiba T, Hirano T, Turner CH, Forwood MR, Johnston CC, Burr DB. Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 2000; 15:613-620.
25. Jerome CP, Burr DB, van Bibber T, Hock JM, Brommage R. Treatment with human parathyroid hormone (1-34) for 18 months increases cancellous bone volume and improves trabecular architecture in ovariectomized cynomolgus monkeys (Macaca fascicularis). Bone 2001; 28:150-159.
26. Hirano T, Burr DB, Turner CH, Sato M, Cain RL, Hock JM. Anabolic effects of human biosynthetic parathyroid hormone fragment (1-34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits. J Bone Miner Res 1999; 14:536-545.
27. Burr DB, Hirano T, Turner CH, Hotchkiss C, Brommage R, Hock JM. Intermittently administered human parathyroid hormone (1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys. J Bone Miner Res 2001; 16:157-165.
28. Zanchetta JR, Bogado CE, Ferretti JL, Wang O, Wilson MG, Sato M, Gaich GA, Dalsky GP, Myers SL. Effects of teriparatide (recombinant human parathyroid hormone (1-34)) on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res 2003; 18:539-543.