Temperature-induced unfolding of epidermal growth factor (EGF): Insight from molecular dynamics simulation

Journal of Molecular Graphics and Modelling

Volumn 29, Issue 1, 2010, Pages 2-12

  Yan, Chunli ^a   Pattani, Varun ^a   Tunnell, James W ^a   Ren, Pengyu ^a  

^a The University of Texas at Austin   (United States)

Author keywords

Free energy landscape; Human epidermal growth factor (EGF); Molten globule; Replica exchange molecular dynamics simulations; Thermal denaturation; Transition state; Unfolding kinetics

Indexed keywords

FREE-ENERGY LANDSCAPE; HUMAN EPIDERMAL GROWTH FACTOR; MOLTEN GLOBULE; REPLICA-EXCHANGE MOLECULAR DYNAMICS SIMULATIONS; THERMAL DENATURATIONS; TRANSITION STATE; UNFOLDING KINETICS;

ACTIVATION ENERGY; BOILING POINT; DENATURATION; DYNAMICS; FREE ENERGY; GROWTH KINETICS; PEPTIDES; PULSED LASER APPLICATIONS;

MOLECULAR DYNAMICS;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GAMMA UROGASTRONE; NANOPARTICLE;

ARTICLE; BINDING SITE; CELL DAMAGE; COMPLEX FORMATION; DIMERIZATION; DRUG RECEPTOR BINDING; HIGH TEMPERATURE; KINETICS; LASER; MOLECULAR DYNAMICS; NANOTECHNOLOGY; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIMULATION; TEMPERATURE DEPENDENCE; THERMAL ANALYSIS; THERMAL INJURY;

EPIDERMAL GROWTH FACTOR; HUMANS; HYDROGEN; MOLECULAR DYNAMICS SIMULATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; TEMPERATURE; TIME FACTORS;

EID: 77955842900     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2010.03.011     Document Type: Article

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